Experimental investigation of pharmacokinetic properties and the accumulation of zinc when administrated nanoform of zinc hydroxide in a comparative aspect with zinc sulfate

The purpose of a preliminary assessment of the biological effect, a comparative study of nanoparticles using test cultures of bakery yeast, the results of which determined the level of inhibition, which was higher than 90%, compared with the figure for the zinc sulfate and the above 145% more compared to the zinc oxide. Investigation was performed on the pharmacokinetic characteristics of the 40 rabbits-males in comparison with that using zinc sulfate, in an enteral or intravenous administration at three dose levels: 10, 50 and 100 mg/k

Myocardial revascularization in patients with acute coronary syndrome in the context of COVID-19 pandemic: a single-center prospective cohort study

Aim. To assess the outcomes of myocardial revascularization (MR) and identify risk factors for early postoperative complications in patients with coronary artery disease (CAD) with acute coronary syndrome (ACS) in the context of coronavirus disease 2019 (COVID-19) pandemic.Material and methods. The study included 769 patients aged 67,0±4,4 years with CAD with ACS in the period from April to October 2020. In an expedited manner, percutaneous transluminal coronary angioplasty (n=699) and on pump coronary artery bypass grafting (CABG) (n=70) were performed. All patients underwent a COVID-19 rapid tests. After MR, the following outcomes were recorded: adverse cardiovascular events and other complications; various surgical interventions; bilateral COVID-19 pneumonia; death. The follow-up period lasted 30 days.Results. During the hospitalization, COVID-19 was detected in 5,3% of patients (n=41). Among them, bilateral multisegmental pneumonia developed in 48,8%. Among infected patients, COVID-19-related mortality in the early postoperative period was 9,8%. The all-cause mortality rate was 0,7%. On pump CABG significantly increases the risk of developing COVID-19 pneumonia (odds ratio (OR), 23,2; 95% confidence interval (CI) 14,2-35,4; p<0,001). After MR, COVID-19 pneumonia was associated with respiratory (OR, 7,6; 95% CI, 4,3-11,5; p=0,001) and heart failure (OR, 4,2; 95% CI, 2,9-8,6; p=0,001), atrial fibrillation (OR, 8,3; 95% CI, 4,1-13,9; p=0,001), as well as with all-cause mortality (OR, 10,3; 95% CI, 5,2-16,7; p=0,005). Recurrent transmural myocardial infarction in patients with CAD was associated with heart failure after MR (OR, 7,1; 95% CI, 2,4-12,6; p=0,012).Conclusion. Conducting on pump CABG in patients with CAD with ACS is the leading trigger for developing COVID-19 pneumonia, which, during hospitalization after MR, was associated not only with respiratory complications, but also with impaired heart function, which significantly increases the death risk in this category of patients

Experimental investigation of pharmacokinetic properties and the accumulation of zinc when administrated nanoform of zinc hydroxide in a comparative aspect with zinc sulfate

The purpose of a preliminary assessment of the biological effect, a comparative study of nanoparticles using test cultures of bakery yeast, the results of which determined the level of inhibition, which was higher than 90%, compared with the figure for the zinc sulfate and the above 145% more compared to the zinc oxide. Investigation was performed on the pharmacokinetic characteristics of the 40 rabbits-males in comparison with that using zinc sulfate, in an enteral or intravenous administration at three dose levels: 10, 50 and 100 mg/k

Control Microelectronic Systems for Power Conditioning of Advanced Spacecraft

Рассмотрены основные проблемы в организации устройств управления силовыми модулями энергопреобразующей аппаратуры космических аппаратов. Предложено решение задачи организации интеллектуального модуля управления на базе однокристальной вычислительной системы специального назначения. Изложена архитектура, программный и аппаратный состав, а также результаты наземных испытаний силового модуля с микроэлектронным управлением. Показана достижимость минимальной конечной длительности переходных процессов в силовом модуле при ступенчатом изменении тока нагрузки.There are considered the major problems of the control unit organization for spacecraft power conditioning system. It is offered a problem solution of intellectual control unit organization based on special purposed system on a chip. The architecture, software and hardware of the microprocessor unit for a digital control circuit implementation are presented. The ground test results of voltage buck regulator are shown. It is shown that the minimal finite duration of transients process in case step change of load current in power module is achievable

Control Microelectronic Systems for Power Conditioning of Advanced Spacecraft

Рассмотрены основные проблемы в организации устройств управления силовыми модулями энергопреобразующей аппаратуры космических аппаратов. Предложено решение задачи организации интеллектуального модуля управления на базе однокристальной вычислительной системы специального назначения. Изложена архитектура, программный и аппаратный состав, а также результаты наземных испытаний силового модуля с микроэлектронным управлением. Показана достижимость минимальной конечной длительности переходных процессов в силовом модуле при ступенчатом изменении тока нагрузки.There are considered the major problems of the control unit organization for spacecraft power conditioning system. It is offered a problem solution of intellectual control unit organization based on special purposed system on a chip. The architecture, software and hardware of the microprocessor unit for a digital control circuit implementation are presented. The ground test results of voltage buck regulator are shown. It is shown that the minimal finite duration of transients process in case step change of load current in power module is achievable