2,265 research outputs found
focusing on employee satisfaction, organizational performance, customer satisfaction, and purchase decision making
Thesis(Master) -- KDI School: Master of Public Management, 2021In the 4.0 Industrial Revolution era, ICT plays a very important role in the national economy, and governments in each country are investing huge budgets to promote "digital transformation" to expand and spread ICT infrastructure. Korea is no exceptional. In July 2020, the "Digital New Deal" was declared, preparing for digital transformation and transformation into a ‘contactless economy’. Then, how do we perceive changes in life through ICT utilization that enables such digital? To confirm this, the effects of producer (STUDY 1) and customer (STUDY 2) side among the three main economic entities, the government, households, and companies, were analyzed. In other words, in order to understand the perception of ICT utilization of both employees (production) and customers (consumption), 272 respondents participated this research survey. And five independent variables and two dependent variables were used, a total of 12 hypothesis tests were conducted for each study. Like most previous studies, ICT utilization had a positive effect on employee satisfaction and organizational performance in the side of production, and positively influenced consumer satisfaction and purchase decision-making from the customer perspective. However, the ‘efficiency’ variable through ICT utilization was rejected in each study, it is presumed that the attributes of ICT, which is connected without restrictions on time and space, hinder the ‘efficiency’ of people in their 20s and 30s, who account for 71% of this research survey.I. Introduction
â…¡. Literature Review
â…¢. Theoretical Background
â…£. Hypotheses Developments
â…¤. Methodology
â…¥. Data Analysis
â…¦. ConclusionmasterpublishedEun Hye Y
Online Retailer’s Return Policy and Prefactual Thinking: A Cross-Cultural Study of U.S. and Chinese E-Commerce Markets
This study examines how online fashion retailers’ return policies differ based on country-of-business. In particular, we examine whether online companies for American consumers are inclined to be more lenient and address American consumer needs to avoid uncertainty and influence prefactual thinking compared to return policies for Chinese consumers
DESIGN OF METAOATA SCHEMA FOR COLLECTING, UTILIZING AND PRESERVING BIOMECHANICAL DATA OF WINTER SPORTS EXPERIMENT
The purpose of this study was to present metadata elements for managing biomechanical data of winter sports experiments and to establish an Integrated Data Management System with the presented metadata elements. To sort and select metadata elements, metadata crosswalk was done with four internationally used metadata schema; Dublin Core, OECD, DataCite, MODS. And a new metadata schema was designed with common elements from the crosswalk and the metadata elements drawn from general experimental designs and R&D portal. The schema was applied to a research data platform Datanest and the Integrated Management System for experimental data of winter sports was established
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS), which is one of the most common HIV-associated neoplasms. The endothelium is the thin layer of squamous cells where vascular blood endothelial cells (BECs) line the interior surface of blood vessels and lymphatic endothelial cells (LECs) are in direct contact with lymphatic vessels. The KS lesions contain a prominent compartment of neoplastic spindle morphology cells that are closely related to LECs. Furthermore, while KSHV can infect both LECs and BECs in vitro, its infection activates genetic programming related to lymphatic endothelial cell fate, suggesting that lymphangiogenic pathways are involved in KSHV infection and malignancy. Here, we report for the first time that viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprouting formation and abnormal growth in a LEC-specific manner. Mass spectrometry analysis revealed that vIRF3 interacted with histone deacetylase 5 (HDAC5), which is a signal-responsive regulator for vascular homeostasis. This interaction blocked the phosphorylation-dependent cytosolic translocation of HDAC5 and ultimately altered global gene expression in LECs but not in BECs. Consequently, vIRF3 robustly induced spindle morphology and hypersprouting formation of LECs but not BECs. Finally, KSHV infection led to the hypersprouting formation of LECs, whereas infection with a ΔvIRF3 mutant did not do so. Collectively, our data indicate that vIRF3 alters global gene expression and induces a hypersprouting formation in an HDAC5-binding-dependent and LEC-specific manner, ultimately contributing to KSHV-associated pathogenesis.IMPORTANCE Several lines of evidences indicate that KSHV infection of LECs induces pathological lymphangiogenesis and that the results resemble KS-like spindle morphology. However, the underlying molecular mechanism remains unclear. Here, we demonstrated that KSHV vIRF3 is readily detected in over 40% of various KS lesions and functions as a potent prolymphangiogenic factor by blocking the phosphorylation-dependent cytosolic translocation of HDAC5, which in turn modulates global gene expression in LECs. Consequently, vIRF3-HDAC5 interaction contributes to virus-induced lymphangiogenesis. The results of this study suggest that KSHV vIRF3 plays a crucial role in KSHV-induced malignancy
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