14,848 research outputs found

    Multidecadal variability in hydro-climate of Okavango river system, southwest Africa, in the past and under future climate

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    The focus of this paper is to understand the multi-decadal oscillatory component of variability in the Okavango River system, in southwestern Africa, and its potential evolution through the 21st century under climate change scenarios. Statistical analyses and hydrological modelling are used to show that the observed multi-decadal wet and dry phases in the Okavango River and Delta result from multi-decadal oscillations in rainfall, which are likely to be related to processes of internal variability in the climate system, rather than external natural or anthropogenic forcing. Analyses of changes in this aspect of variability under projected climate change scenarios are based on data from a multi-model ensemble of 19 General Circulation Models, which are used to drive hydrological models of the Okavango River and Delta. Projections for the 21st century indicate a progressive shift towards drier conditions attributed to the influence of increasing temperatures on water balance. It is, however, highly likely that multi-decadal oscillations, possibly of similar magnitude to that of 20th century, will be superimposed on the overall trend. These may periodically offset or amplify the mean drying trend. This effect should be accounted for in water and catchment management and climate change adaptation strategies

    SCREENING FOR HEPATITIS C Response from Hepatitis C Trust, BASL, BIA, BVHG, BSG, and BHIVA to article asking whether widespread screening for hepatitis C is justified

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    This is the peer reviewed published version of the following article: Response from Hepatitis C Trust, BASL, BIA, BVHG, BSG, and BHIVA to article asking whether widespread screening for hepatitis C is justified, which has been published in final form at 10.1136/bmj.h998. This article may be used for non-commercial purposes in accordance with BMJ's Terms and Conditions for Self-Archiving.This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/ by/4.0

    A new method of observing weak extended x-ray sources with RHESSI

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    We present a new method, fan-beam modulation, for observing weak extended x-ray sources with the Reuven Ramaty High-Energy Solar Spectroscopic Imager (RHESSI). This space-based solar x-ray and gamma-ray telescope has much greater sensitivity than previous experiments in the 3-25 keV range, but is normally not well suited to detecting extended sources since their signal is not modulated by RHESSI's rotating grids. When the spacecraft is offpointed from the target source, however, the fan-beam modulation time-modulates the transmission by shadowing resulting from exploiting the finite thickness of the grids. In this paper we detail how the technique is implemented and verify its consistency with sources with clear known signals that have occurred during RHESSI offpointing: microflares and the Crab Nebula. In both cases the results are consistent with previous and complementary measurements. Preliminary work indicates that this new technique allows RHESSI to observe the integrated hard x-ray spectrum of weak extended sources on the quiet Sun.Comment: Publishe

    Gene-history correlation and population structure

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    Correlation of gene histories in the human genome determines the patterns of genetic variation (haplotype structure) and is crucial to understanding genetic factors in common diseases. We derive closed analytical expressions for the correlation of gene histories in established demographic models for genetic evolution and show how to extend the analysis to more realistic (but more complicated) models of demographic structure. We identify two contributions to the correlation of gene histories in divergent populations: linkage disequilibrium, and differences in the demographic history of individuals in the sample. These two factors contribute to correlations at different length scales: the former at small, and the latter at large scales. We show that recent mixing events in divergent populations limit the range of correlations and compare our findings to empirical results on the correlation of gene histories in the human genome.Comment: Revised and extended version: 26 pages, 5 figures, 1 tabl

    The effect of topology on the structure and free energy landscape of DNA kissing complexes

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    We use a recently developed coarse-grained model for DNA to study kissing complexes formed by hybridization of complementary hairpin loops. The binding of the loops is topologically constrained because their linking number must remain constant. By studying systems with linking numbers -1, 0 or 1 we show that the average number of interstrand base pairs is larger when the topology is more favourable for the right-handed wrapping of strands around each other. The thermodynamic stability of the kissing complex also decreases when the linking number changes from -1 to 0 to 1. The structures of the kissing complexes typically involve two intermolecular helices that coaxially stack with the hairpin stems at a parallel four-way junction

    Nearby Optical Galaxies: Selection of the Sample and Identification of Groups

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    In this paper we describe the Nearby Optical Galaxy (NOG) sample, which is a complete, distance-limited (cz≤cz\leq6000 km/s) and magnitude-limited (B≤\leq14) sample of ∼\sim7000 optical galaxies. The sample covers 2/3 (8.27 sr) of the sky (∣b∣>20∘|b|>20^{\circ}) and appears to have a good completeness in redshift (98%). We select the sample on the basis of homogenized corrected total blue magnitudes in order to minimize systematic effects in galaxy sampling. We identify the groups in this sample by means of both the hierarchical and the percolation {\it friends of friends} methods. The resulting catalogs of loose groups appear to be similar and are among the largest catalogs of groups presently available. Most of the NOG galaxies (∼\sim60%) are found to be members of galaxy pairs (∼\sim580 pairs for a total of ∼\sim15% of objects) or groups with at least three members (∼\sim500 groups for a total of ∼\sim45% of objects). About 40% of galaxies are left ungrouped (field galaxies). We illustrate the main features of the NOG galaxy distribution. Compared to previous optical and IRAS galaxy samples, the NOG provides a denser sampling of the galaxy distribution in the nearby universe. Given its large sky coverage, the identification of groups, and its high-density sampling, the NOG is suited for the analysis of the galaxy density field of the nearby universe, especially on small scales.Comment: 47 pages including 6 figures. Accepted for publication in Ap
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