67 research outputs found
Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis
Severe sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic manipulation of death and survival pathways has been shown to modulate organ injury and survival.We investigated the effect of extracellular administration of two anti-apoptotic members of the BCL2 (B-cell lymphoma 2) family of intracellular regulators of cell death in a murine model of sepsis induced by cecal ligation and puncture (CLP). We show that intraperitoneal injection of picomole range doses of recombinant human (rh) BCL2 or rhBCL2A1 protein markedly improved survival as assessed by surrogate markers of death. Treatment with rhBCL2 or rhBCL2A1 protein significantly reduced the number of apoptotic cells in the intestine and heart following CLP, and this was accompanied by increased expression of endogenous mouse BCL2 protein. Further, mice treated with rhBCL2A1 protein showed an increase in the total number of neutrophils in the peritoneum following CLP with reduced neutrophil apoptosis. Finally, although neither BCL2 nor BCL2A1 are a direct TLR2 ligand, TLR2-null mice were not protected by rhBCL2A1 protein, indicating that TLR2 signaling was required for the protective activity of extracellularly adminsitered BCL2A1 protein in vivo.Treatment with rhBCL2A1 or rhBCL2 protein protects mice from sepsis by reducing apoptosis in multiple target tissues, demonstrating an unexpected, potent activity of extracellularly administered BCL2 BH4-domain proteins
Two-photon widths of the χ c0,2 states and helicity analysis for χ c2→γγ
Based on a data sample of 106×106 ψ ′ events collected with the BESIII detector, the decays ψ ′→γχ c0,2, χ c0,2→γγ are studied to determine the two-photon widths of the χ c0,2 states. The two-photon decay branching fractions are determined to be B(χ c0→γγ)=(2. 24±0.19±0.12±0.08)×10 -4 and B(χ c2→γγ)=(3.21±0.18±0. 17±0.13)×10 -4. From these, the two-photon widths are determined to be Γ γγ(χ c0)=(2. 33±0.20±0.13±0.17)keV, Γ γγ(χ c2)=(0.63±0.04±0. 04±0.04)keV, and R=Γ γγ(χ c2)/ Γ γγ(χ c0)=0.271±0. 029±0.013±0.027, where the uncertainties are statistical, systematic, and those from the PDG B(ψ ′→γχ c0,2) and Γ(χ c0,2) errors, respectively. The ratio of the two-photon widths for helicity λ=0 and helicity λ=2 components in the decay χ c2→γγ is measured for the first time to be f 0/2=Γγγλ= 0(χ c2)/Γγγλ=2(χ c2)=0. 00±0.02±0.02. © 2012 American Physical Society.published_or_final_versio
Search for a light exotic particle in J/psi radiative decays
Using a data sample containing 1.06x10^8 psi' events collected with the
BESIII detector at the BEPCII electron-positron collider, we search for a light
exotic particle X in the process psi' -> pi^+ pi^- J/psi, J/psi -> gamma X, X
-> mu^+ mu^-. This light particle X could be a Higgs-like boson A^0, a spin-1 U
boson, or a pseudoscalar sgoldstino particle. In this analysis, we find no
evidence for any mu^+mu^- mass peak between the mass threshold and 3.0 GeV/c^2.
We set 90%-confidence-level upper limits on the product-branching fractions for
J/psi -> gamma A^0, A^0 -> mu^+ mu^- which range from 4x10^{-7} to 2.1x10^{-5},
depending on the mass of A^0, for M(A^0)<3.0 GeV/c^2. Only one event is seen in
the mass region below 255 MeV/c^2 and this has a mu^+mu^- mass of 213.3 MeV/c^2
and the product branching fraction upper limit 5x10^{-7}.Comment: 7 pages, 3 figures, submitted to Physical Review
Measurement of the matrix element for the decay η′→ηπ +π -
The Dalitz plot of η⊃′→ηπ⊃+π⊃- decay is studied using (225.2±2.8)×106 J/ψ events collected with the BESIII detector at the BEPCII e⊃+e⊃- collider. With the largest sample of η⊃′ decays to date, the parameters of the Dalitz plot are determined in a generalized and a linear representation. Also, the branching fraction of J/ψ→γη⊃′ is determined to be (4.84±0.03±0.24)×10⊃-3, where the first error is statistical and the second systematic. © 2011 American Physical Society.published_or_final_versio
First observation of the decays χcJ→π0π0π0π0
We present a study of the P-wave spin-triplet charmonium χ cJ decays (J=0, 1, 2) into π0π0π0π0. The analysis is based on 106×106 ψ⊃′ decays recorded with the BESIII detector at the BEPCII electron positron collider. The decay into the π0π0π0π0 hadronic final state is observed for the first time. We measure the branching fractions B(χ c0→π0π0π0π0)=(3.34±0. 06±0.44)×10⊃-3, B(χ c1→π0π0π0π0) =(0.57±0.03±0.08)×10⊃-3, and B(χ c2→π0π0π0π0)=(1.21±0.05±0.16) ×10⊃-3, where the uncertainties are statistical and systematical, respectively. © 2011 American Physical Society.published_or_final_versio
Higher-order multipole amplitude measurement in ψ ′→γχ c2
Using 106×106 ψ ′ events collected with the BESIII detector at the BEPCII storage ring, the higher-order multipole amplitudes in the radiative transition ψ ′→γχ c2→γπ +π -/γK +K - are measured. A fit to the χ c2 production and decay angular distributions yields M2=0.046±0. 010±0.013 and E3=0.015±0.008±0.018, where the first errors are statistical and the second systematic. Here M2 denotes the normalized magnetic quadrupole amplitude and E3 the normalized electric octupole amplitude. This measurement shows evidence for the existence of the M2 signal with 4.4σ statistical significance and is consistent with the charm quark having no anomalous magnetic moment. © 2011 American Physical Society.published_or_final_versio
Study of a00(980)-f0(980) mixing
Using samples of 2.25×108 J/ψ events and 1.06×108 ψ ′ events collected with the BES III detector, we study the f 0(980)→a00(980) and a00(980)→f 0(980) transitions in the processes J/ψ→φf 0(980) →φa00(980) and χ c1→π0a00(980)→π0f 0(980), respectively. Evidence for f 0(980)→a00(980) is found with a significance of 3.4σ, while in the case of a00(980)→f 0(980) transition, the significance is 1.9σ. Measurements and upper limits of both branching ratios and mixing intensities are determined. © 2011 American Physical Society.published_or_final_versio
Observation of \chi_{cJ} decaying into the p\bar{p}K^{+}K^{-} final state
First measurements of the decays of the three states to
final states are presented. Intermediate and resonance states are observed, and
branching fractions for ,
, and are reported. We also
measure branching fractions for direct
decays. These are first observations of decays to unstable baryon
resonances and provide useful information about the states. The
experiment uses samples of mesons produced via radiative
transitions from 106 million mesons collected in the BESIII
detector at the BEPCII collider.Comment: 16 pages, 5 figure
Evidence for psi' decays into gamma pi^0 and gamma eta
The decays psi'->gamma pi^0, gamma eta and gamma eta' are studied using data
collected with the BESIII detector at the BEPCII e^+e^- collider. Processes
psi'->gamma pi^0 and psi'->gamma eta are observed for the first time with
signal significances of 4.6 sigma and 4.3 sigma, respectively. The branching
fractions are determined to be: B(psi'->gamma pi^0)=(1.58+-0.40+-0.13)x10^{-6},
B(psi'->gamma eta)=(1.38+-0.48+-0.09)x10^{-6}, and B(psi'->gamma
eta')=(126+-3+-8) x 10^{-6}, where the first errors are statistical and the
second ones systematic.Comment: 6 pages, 4 figure
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