Band Crossing studied by GCM with 3D-CHFB

We solved the constrained Hill-Wheeler Equation, and found several signatures of multi-band crossing in 182 Os.Comment: LaTeX 3 pages, 3 eps figures; Contribution to International Conference, Nuclear Structure at the extreme,Lewes, UK, (1998) Jun.17-1

Stability of s-band states in the tilting calculation of 182Os

We carried out the three-dimensional cranking calculations for osmium 182Os within the Hartree-Fock-Bogoliubov framework. It turned out that the state in the g-band is stable (unstable) with respect to the tilt angle of the cranking axis when the angular momentum is below (above) a critical value. However, the states in the s-band with the angular momentum below 30[h-bar] are unstable everywhere along the band. In our model calculations, the wobbling motion does not exist on top of the s-band state characterized by the component of two aligned particles

Second Backbend in the Mass A ~ 180 Region

Within the framework of selfconsistent cranked Hartree-Fock- Bogoliubov theory(one-dimensional) we predict second backbend in the yrast line of Os-182 at $I \approx 40$, which is even sharper than the first one observed experimentally at $I \approx 14$. Around such a high spin the structure becomes multi-quasiparticle type, but the main source of this strong discontinuity is a sudden large alignment of i_13/2 proton orbitals along the rotation axis followed soon by the alignment of j_15/2 neutron orbitals. This leads to drastic structural changes at such high spins. When experimentally confirmed, this will be observed for the first time in this mass region, and will be at the highest spin so far.Comment: 13 pages, 4 ps figure

UVSSA and USP7, a new couple in transcription-coupled DNA repair

Transcription-coupled nucleotide excision repair (TC-NER) specifically removes transcription-blocking lesions from our genome. Defects in this pathway are associated with two human disorders: Cockayne syndrome (CS) and UV-sensitive syndrome (UVSS). Despite a similar cellular defect in the UV DNA damage response, patients with these syndromes exhibit strikingly distinct symptoms; CS patients display severe developmental, neurological, and premature aging features, whereas the phenotype of UVSS patients is mostly restricted to UV hypersensitivity. The exact molecular mechanism behind these clinical differences is still unknown; however, they might be explained by additional functions of CS proteins beyond TC-NER. A short overview of the current hypotheses addressing possible molecular mechanisms and the proteins involved are presented in this review. In addition, we will focus on two new players involved in TC-NER which were recently identified: UV-stimulated scaffold protein A (UVSSA) and ubiquitin-specific protease 7 (USP7). UVSSA has been found to be the causative gene for UVSS and, together with USP7, is implicated in regulating TC-NER activity. We will discuss the function of UVSSA and USP7 and how the discovery of these proteins contributes to a better understanding of the molecular mechanisms underlying the clinical differences between UVSS and the more severe CS

Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids

<p>Abstract</p> <p>Background</p> <p>Boar taint is observed in a high proportion of uncastrated male pigs and is characterized by an unpleasant odor/flavor in cooked meat, primarily caused by elevated levels of androstenone and skatole. Androstenone is a steroid produced in the testis in parallel with biosynthesis of other sex steroids like testosterone and estrogens. This represents a challenge when performing selection against androstenone in breeding programs, without simultaneously decreasing levels of other steroids. The aim of this study was to use high-density genome wide association (GWA) in combination with linkage disequilibrium-linkage analysis (LDLA) to identify quantitative trait loci (QTL) associated with boar taint compounds and related sex steroids in commercial Landrace (n = 1,251) and Duroc (n = 918) breeds.</p> <p>Results</p> <p>Altogether, 14 genome wide significant (GWS) QTL regions for androstenone in subcutaneous fat were obtained from the LDLA study in Landrace and 14 GWS QTL regions in Duroc. LDLA analysis revealed that 7 of these QTL regions, located on SSC 1, 2, 3, 7 and 15, were obtained in both breeds. All 14 GWS androstenone QTLs in Landrace are also affecting the estrogens at chromosome wise significance (CWS) or GWS levels, while in Duroc, 3 of the 14 QTLs affect androstenone without affecting any of the estrogens. For skatole, 10 and 4 QTLs were GWS in the LDLA analysis for Landrace and Duroc respectively, with 4 of these detected in both breeds. The GWS QTLs for skatole obtained by LDLA are located at SSC 1, 5, 6, 7, 10, 11, 13 and 14.</p> <p>Conclusion</p> <p>This is the first report applying the Porcine 60 K SNP array for simultaneous analysis of boar taint compounds and related sex hormones, using both GWA and LDLA approaches. Several QTLs are involved in regulation of androstenone and skatole, and most of the QTLs for androstenone are also affecting the levels of estrogens. Seven QTLs for androstenone were detected in one breed and confirmed in the other, i.e. in an independent sample, although the majority of QTLs are breed specific. Most QTLs for skatole do not negatively affect other sex hormones and should be easier to implement into the breeding scheme.</p