20 research outputs found

    Cohort Profile: The Malawi Longitudinal Study of Families and Health (MLSFH)

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    The Malawi Longitudinal Study of Families and Health (MLSFH) is one of very few long-standing publicly-available longitudinal cohort studies in a sub-Saharan African (SSA) context. It provides a rare record of more than a decade of demographic, socioeconomic and health conditions in one of the world\u27s poorest countries. With data collection rounds in 1998, 2001, 2004, 2006, 2008, 2010 and 2012 for up to 4,000 individuals, the MLSFH permits researchers to investigate the multiple influences that contribute to HIV risks in sexual partnerships, the variety of ways that people manage risk within and outside of marriage, the possible effects of HIV prevention policies and programs, and the mechanisms through which poor rural individuals, families, households, and communities cope with the impacts of high morbidity and mortality that are often---but not always---related to HIV/AIDS. The MLSFH been used to document (i) the influence of social networks on HIV-related behaviors and perceptions, (ii) the HIV prevention strategies employed by individuals in rural high-HIV prevalence contexts, (iii) the relationship between life-course transitions and HIV infection risks, (iv) the acceptability of HIV testing and counseling (HTC) and the consequences of HTC on subsequent behaviors, and (v) the health and well-being across the life-course of individuals facing multiple challenges resulting from high disease burdens and widespread poverty

    Prise en charge des endométriomes en France : enquête de pratiques

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    International audienceObjectivesTo present an overview of French practices for the management of endometriomas.MethodsWe carried out a nationwide survey of practices concerning the management of endometriomas between October 2021 and January 2022. This study was carried out by means of two questionnaires sent to surgical centers used to treat endometriosis (n = 62) and to Assisted Reproductive Technology (ART) centers (n = 102).ResultsAt the end of the survey, 39/62 (62.9%) surgical teams from the centers contacted had given a response and 51/102 (50.0%) from ART centers. Laparoscopic cystectomy was the technique most frequently used by almost two thirds of the surgical teams (61%) when there was no known infertility, whereas it was the most common technique for only 14% of the ART teams. On the contrary, ultrasound-guided sclerotherapy was the most frequent technique for more than half of the ART teams (56%) and for only 8% of the surgical teams. In case of recurrence, 49% of surgical teams would choose ultrasound-guided sclerotherapy. Prior to IVF, 73% of ARP teams stated that they ‘rarely’ treated endometriomas.ConclusionThe results of our study show a certain variability in practices between different centers and depending on the presence or absence of infertility for the management of endometriomas in France.ObjectifsPrésenter un état des lieux des pratiques françaises pour la prise en charge des endométriomes.MéthodesNous avons réalisé une enquête de pratiques, à l’échelle nationale, concernant la prise en charge des endométriomes entre octobre 2021 et janvier 2022. Cette étude a été réalisée par le biais de deux questionnaires adressés à des centres de chirurgie ayant l’habitude de prendre en charge l’endométriose (n = 62) ainsi que les centres d’assistance médicale à la procréation (AMP ; n = 102).RésultatsÀ l’issue de l’enquête, 39/62 (62,9 %) équipes chirurgicales des centres contactés avaient donné une réponse et 51/102 (50,0 %) pour les AMP. La kystectomie par cœlioscopie était la technique la plus fréquemment utilisée par près de deux tiers des équipes de chirurgie (61 %) lorsqu’il n’existait pas de contexte d’infertilité connue alors qu’il s’agit de la technique la plus courante pour seulement 14 % des équipes d’assistance médicale à la procréation (AMP). La sclérothérapie échoguidée était au contraire la technique la plus fréquente pour plus de la moitié des équipes d’AMP (56 %) et pour seulement 8 % des équipes de chirurgie. En cas de récidive, 49 % des équipes de chirurgie choisiraient la sclérothérapie échoguidée. Avant une fécondation in vitro (FIV), 73 % des équipes d’AMP déclaraient traiter « rarement » les endométriomes.ConclusionLes résultats de notre étude montrent une certaine variabilité dans les pratiques entre les différents centres et en fonction de la présence ou non d’une infertilité pour la prise en charge des endométriomes en France

    Severe cerebral swelling is not observed in children dying with malaria

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    In an autopsy study in Abidjan, Cote d'lvoire, 14/155 brains of children <13 years had malaria parasites within cerebral blood vessels. This was associated with cerebral swelling (57% of brains), ventricular compression (86%) and mild basal grooving (43%), but not with coning of the medulla and cerebellum. The pathophysiology of cerebral malaria does not culminate in severe raised intracranial pressure and herniation, and over-concern over the safety of lumbar puncture in malaria may not be warranted
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