Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged Japanese adults: A 22-year follow up of NIPPON DATA90

滋賀医科大学博士（医学）application/pdfThesis or DissertationJournal of diabetes investigation. 2022 Nov;13(11):1897-1904.令和4年度thesi

Effect of Rare Earth on M7C3 Eutectic Carbide in 13% Chromium Alloy Cast Iron

The crystallization process of hypoeutectic white cast iron consists of the first secreted austenite branch after the reaction of the austenite -carbide crystal is formed, and the phase crystal fills in the middle of the austenite branches. If the austenite branches are small and smooth, the crystals carbide are fine. The cast iron with 13% chromium which has 3 – 3.2% carbon, have the carbide crystalline as M7C3. The elements in rare earth have a strong affinity for oxygen and sulfur to produce rare earth oxides. These rare earth oxides can create heterogeneous germ center for austenite phases and smooth down these phases. The effect of rare earth on the M7C3 and crystals of 13% chrome white iron has been elucidated. Along with the increase of rare earth content, the microstructure of M7C3 with fine finely graded, more uniformly distributed, dispersed throughout the sample surface. When the carbide is fine and dispersion, will contribute to improving the properties of cast iron especially the impact strength as well as the abrasion resistance of the alloy. The research results show that in the presence of rare earth, rare earth elements created with oxygen and form La2O3 and Ce2O3 as the nucleation for the solidification process and create the small fineness of phases. The orientation of the crystal structure of these oxides is similar to the crystal structure orientation of Fe-γ phase. Finding and proving the oxides of rare earth has crystal structure with phase γ which will be small smooth exogenous minds that the microstructure has a smooth, small size

Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged Japanese adults : A 22-year follow up of NIPPON DATA90.

Aims/introduction:To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22-year period among middle-aged Japanese adults.Materials and methods:Participants consisted of 1,788 adults aged 45-64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein), at baseline.Results:In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07-1.91 and OR 1.66, 95% CI 1.10-2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16-2.08 and OR 1.77, 95% CI 1.18-2.65, respectively) than individuals with normal glucose tolerance.Conclusions:In middle-aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life

Unmet Healthcare Needs and Associated Factors in Rural and Suburban Vietnam: A Cross-Sectional Study

The purpose of this study was to examine the current utilization of healthcare services, exploring unmet healthcare needs and the associated factors among people living in rural Vietnam. This cross-sectional study was conducted with 233 participants in a rural area. The methods included face-to-face interviews using a structured questionnaire, and anthropometric and blood pressure measurements. We considered participants to have unmet health needs if they had any kind of health problem during the past 12 months for which they were unable to see a healthcare provider. Multivariate logistic regression analysis was performed to determine the factors associated with unmet healthcare needs. Of the participants, 18% (n = 43) had unmet healthcare needs, for reasons like transportation (30%), a lack of available doctors or medicine (47%), and communication issues with healthcare providers (16%). The multivariate logistic regression showed that living in a rural area, having stage 2 hypertension, and having insurance were associated with unmet healthcare needs. To better meet the healthcare needs in rural or suburban areas of Vietnam, allocation of adequate healthcare resources should be distributed in rural areas and insurance coverage for personalized healthcare needs might be required. Efforts should focus on availability of medicine, improvement of transportation systems, and communication skills of healthcare providers to improve access to healthcare services

Occurrence of endophytic bacteria in Vietnamese Robusta coffee roots and their effects on plant parasitic nematodes

Several plant parasitic nematode genera were identified in the Robusta coffee (Coffea canephora Pierre ex A. Froehn) tree roots and surrounding soil samples from three different coffee groups: coffee planted at 5 years (CYG), 18 years (CBG) and 40 years (COG) in Central Highland, Vietnam. They included Meloidogyne spp., Pratylenchus spp., Apratylenchus spp., Criconemella spp., Xiphinema spp. and Rotylenchulus spp. Meloidogyne spp. was the most abundant genus, at 77% across all three groups. Endophytic bacteria were isolated from healthy tissues of roots of the same Robusta coffee trees. In total, 77 bacterial strains were isolated and determined to be Bacillus spp., Serratia spp., Paenibacillus spp., Enterobacter spp. and Streptomyces spp. based on colony morphological and 16S rRNA gene sequence analysis. Overall, Streptomyces was the dominant genus and accounted for 49.35% of total isolated strains. Using statistical methods, we found a tendency in the abundance of endophytic bacterial isolates with the elevation or decrease of several nematode populations, indicating a relation between endophytic bacteria occurrence and nematode distribution. In in vitro anti nematode screening test, a Streptomyces sp. strain named CBG9 showed significant nematicidal activities against Meloidogyne incognita, inhibiting egg hatching (85.8%) and causing mortality of secondary stage juveniles (85%). This study explored the anti-nematode potency of endophytic bacteria isolated from coffee trees, which could provide a future application in suppression and management of pathogenic nematodes without the use of chemical pesticides

Trends in mortality from major causes and lifestyle factors by per capita prefectural income: Ecological panel data analysis from 1995 to 2016 in Japan

In Japan, trends in mortality and lifestyle have not been fully investigated according to subnational socioeconomic factors. Forty-seven prefectures (subnational units) were divided into quartiles by annual per capita prefectural income. Age-standardized mortality from all causes, cancer, heart disease, and stroke was averaged by quartile in 1995, 2000, 2005, 2010, and 2015. Data from the National Health and Nutrition Survey were obtained for periods 1 (1995–1997), 2 (1999–2001), 3 (2003–2005), 4 (2007–2009), 5 (2012), and 6 (2016). Body mass index (BMI), the intake of vegetables and salt, the number of steps, and the prevalence of current smoking and drinking for the 40–69-year age range were standardized by 10-year age groups in the 2010 Japanese population and were averaged by quartile. Differences in mortality and lifestyle by year and period, and quartile were tested using a two-way analysis of variance. Mortality decreased in both sexes and mortality in men from all causes, cancer, and stroke differed by quartile, with mortality highest in the first (lowest) quartile. BMI in men and smoking prevalence in women increased, whereas remaining lifestyle factors except for the prevalence of drinking decreased in women. BMI and the number of steps in both sexes and current smoking prevalence in women differed by quartile, with lower quartiles showing a higher BMI and fewer step counts. In conclusion, favorable trends and significant differences in mortality from all causes, cancer, and stroke in men and BMI in women were observed by per capita prefectural income level