Fluctuations in active membranes

Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well as homeostasis. Membrane fluctuations contain therefore valuable information on the nature of active forces, but classical analysis of membrane fluctuations has been primarily centered on purely thermal driving. This chapter provides an overview of relevant experimental and theoretical approaches to measure, analyze and model active membrane fluctuations. In the focus of the discussion remains the intrinsic problem that the sole fluctuation analysis may not be sufficient to separate active from thermal contributions, since the presence of activity may modify membrane mechanical properties themselves. By combining independent measurements of spontaneous fluctuations and mechanical response, it is possible to directly quantify time and energy-scales of the active contributions, allowing for a refinement of current theoretical descriptions of active membranes.Comment: 38 pages, 9 figures, book chapte

Bovine Tuberculosis and Badger Control in Britain: Science, Policy and Politics

Bovine tuberculosis (bovine TB) is the most economically important animal health policy issue in Britain. The problem of what to do about badgers has plagued successive governments since a dead badger was discovered with bovine TB in 1971. Successive Labour governments (1997–2010) oversaw the Randomised Badger Culling Trial (RBCT) from 1998 to 2006. Despite the RBCT recommendation against culling, the 2010–2015 Coalition government implemented pilot badger culls. This paper provides an account of the evolution of bovine TB and badger control policy, focusing on the 1997–2010 Labour, the 2010–2015 Coalition and the 2015-present Conservative governments. Interviews with bovine TB policy stakeholders supplement discussion of the development of bovine TB policy. The paper discusses the science and politics of bovine TB policy, in which there are different badger control policies in Westminster, Welsh and Scottish governments. Badger control is a highly polarised issue, and the Coalition and Conservative governments have been heavily criticised for a culling policy opposed by the independent scientific community. Recent governments have defended badger culling on the basis of veterinary advice and experience in countries such as New Zealand. The paper concludes with two key recommendations to inform controversial animal health and welfare policy issues such as bovine TB. First, mandatory Animal Welfare Impact Assessment provides objective data on the impacts of policy options on cows and badgers. Second, robust ethical analysis, conducted by independent experts using established moral frameworks, should be applied to animal health and welfare issues for the benefit of decision makers

The Development of an Animal Welfare Impact Assessment (AWIA) Tool and Its Application to Bovine Tuberculosis and Badger Control in England

Bovine tuberculosis (bovine TB) is a controversial animal health policy issue in England, which impacts farmers, the public, cattle and badgers. Badgers (Meles meles) act as a wildlife reservoir of disease. Policy options for badger control include (1) do nothing, (2) badger culling, and (3) badger vaccination. This paper argues for mandatory Animal Welfare Impact Assessment (AWIA) for all policy that significantly affects sentient animals. AWIA includes (1) species description, and (2) AWIA analysis stages. In this paper, AWIA is applied to impacts of bovine TB policy options on cattle and badgers. Over 4 years, 85,000 badgers will be culled to prevent the slaughter of ~17,750 cattle over 9 years. Hence, about five badgers are culled for every cow which avoids slaughter. The AWIA analyses the impact of badger vaccination on cows and badgers based on a set of stated assumptions. The AWIA estimates badger vaccination to reduce the number of cows slaughtered by 11,600, i.e. a 12.5% reduction. Additional to the harm of killing, culling has greater welfare impacts on badgers compared to non-culling options. Actors in animal health and welfare policy were interviewed about the concept of AWIA. Policy actors supported the idea of AWIA to provide objective data to feed into policy making. The paper concludes with the proposal that AWIA is a necessary stage of just policy making where sentient animals are impacted by government policy

A critical inquiry into the hyperreality of digitalization in construction

The built environment is literally and metaphorically concrete but its creation from conception through design and construction involves many levels of abstraction. This spectrum of activities between concrete and abstract is complex and unexplored in construction but it will be shown that a deep understanding of this is required to make successful buildings in a modern age of digitalization. Abstraction is the simplification of an entity with a degree of generalization of purpose and causality but also used to promote the idealization of the entity. When abstractions are believed to be real then there are conditions of hyperreality. This article unpacks the nature of abstraction in the creation of the built environment through three vignettes of practice; considering: drawings, project planning and building modelling. Abstraction has been key to making buildings but is growing in significance because of building information modelling. The themes of loss of meaning, loss of control and loss of perspective are used to show that digitalization involves creating a dangerous illusion of the connection between data and reality thus creating a problematic hyperreality. This can be avoided by stronger thinking, more openness about abstractions and less exaggeration of their performance