Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities

Background Epidermal growth factor receptor inhibitors (EGFRI) produce various dermatologic side effects in the majority of patients, and guidelines are crucial for the prevention and treatment of these untoward events. The purpose of this panel was to develop evidence-based recommendations for EGFRI-associated dermatologic toxicities. Methods A multinational, interdisciplinary panel of experts in supportive care in cancer reviewed pertinent studies using established criteria in order to develop first-generation recommendations for EGFRI-associated dermatologic toxicities. Results Prophylactic and reactive recommendations for papulopustular (acneiform) rash, hair changes, radiation dermatitis, pruritus, mucositis, xerosis/fissures, and paronychia are presented, as well as general dermatologic recommendations when possible. Conclusion Prevention and management of EGFRI-related dermatologic toxicities is critical to maintain patients’ health-related quality of life and dose intensity of antineoplastic regimens. More rigorous investigation of these toxicities is warranted to improve preventive and treatment strategies

Executive recruitment and selection: a literature review

This article examines union responses to the reorganization of call centre work in Germany, drawing on case studies from the telecommunications, financial services and subcontractor industries. Service unions initially adopted innovative strategies to organize these workplaces, response to threats and opportunities presented by the rapid growth of a new \u27sector. However, the new conglomerate service union, ver.di, has been unable to sustain these alternative strategies due to both institutional and organizational factors. The increasingly fragmented character the German industrial relations system provides growing exit options for employers, while union is disadvantaged by declining membership, resource scarcity and an organizational structure reflecting past industry (and union) boundaries. Ver.di thus finds itself in an institutionally enhanced innovation dilemma. Sustaining innovations necessary to organize new workplaces would require organizational slack and redundant resources. However, environmental pressures of changing employer strategies and institutional erosion limit the possibilities for mobilizing these resources