Sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy

We report a case of a sympathetic ophthalmia that occurred after 23-gauge transconjunctival sutureless vitrectomy for a retinal detachment

Cognitive Profile of Idiopathic Normal Pressure Hydrocephalus

Background/Aims: Frontal lobe dysfunction is believed to be a primary cognitive symptom in idiopathic normal pressure hydrocephalus (iNPH); however, the neuropsychology of this disorder remains to be fully investigated. The objective of this study was to delineate a comprehensive profile of cognitive dysfunction in iNPH and evaluate the effects of cerebrospinal fluid (CSF) shunt surgery on cognitive dysfunction. Methods: A total of 32 iNPH patients underwent neuropsychological testing of memory, attention, language, executive function, and visuoperceptual and visuospatial abilities. Of these 32 patients, 26 were reevaluated approximately 1 year following CSF shunt surgery. The same battery of tests was performed on 32 patients with Alzheimer’s disease (AD) and 30 healthy elderly controls. Results: The iNPH patients displayed baseline deficits in attention, executive function, memory, and visuoperceptual and visuospatial functions. Impairments of attention, executive function, and visuoperceptual and visuospatial abilities in iNPH patients were more severe than in those with AD, whereas the degree of memory impairment was comparable to that in AD patients. A significant improvement in executive function was observed following shunt surgery. Conclusion: Patients with iNPH are impaired in various aspects of cognition involving both ‘frontal’ executive functions and ‘posterior cortical’ functions. Shunt treatment can ameliorate executive dysfunction

Detection of an H-alpha Emission Line on a Quasar, RX J1759.4+6638, at z=4.3 with AKARI

We report the detection of an H-alpha emission line in the low resolution spectrum of a quasar, RX J1759.4+6638, at a redshift of 4.3 with the InfraRed Camera (IRC) onboard the AKARI. This is the first spectroscopic detection of an H-alpha emission line in a quasar beyond z=4. The overall spectral energy distribution (SED) of RX J1759.4+6638 in the near- and mid-infrared wavelengths agrees with a median SED of the nearby quasars and the flux ratio of F(Ly-alpha)/F(H-alpha) is consistent with those of previous reports for lower-redshift quasars.Comment: 9pages, 3 figures, Publications of the Astronomical Society of Japan, in pres

Error Visualization for Pencil Drawing with Three-Dimensional Model

初心者のための鉛筆デッサンの基礎は，対象を見えたまま正確に描きとる写実であり，獲得が難しい技能である．初心者は自己の写実の誤りに気づくことができない，あるいはデッサン画全体に漠然とした違和感を感じることができても，具体的に写実の何が誤りかを判断できず，同じ誤りを繰り返す．反復練習を指導する教師は，写実の誤りを理解させるため，描く対象と異なった立体物をイメージさせるたとえ（比喩）を用いる．学習者は比喩説明を聞く過程で徐々に，明らかに異なるイメージの写実と感じるようになり，ついに自己の写実の誤りに気づくと考えられる．本論文は学習者の鉛筆デッサン画像に含まれる写実の誤りを顕在化した三次元モデルを構築する手法を検討する．本手法は誤った写実による1 枚の画像から，誤りを映し出し，かつ直感的に不自然さを感じさせる三次元モデルを構築する．写実の8 種の誤りを対象に，デッサン画像の誤りを特徴づける15個の特徴量を用いて三次元モデルのスケーリング変換を定義した．三次元モデルを表示する顕在化ツールを実装した．学習者が本ツールを用いることで，鉛筆デッサンに含まれる写実の誤りに気づきやすくなると期待できる．本研究の一部は文部科学省科学研究補助金基盤研究（B）（2）（課題番号：163000369）による

Near-infrared and Mid-infrared Spectroscopy with the Infrared Camera (IRC) for AKARI

The Infrared Camera (IRC) is one of the two instruments on board the AKARI satellite. In addition to deep imaging from 1.8-26.5um for the pointed observation mode of the AKARI, it has a spectroscopic capability in its spectral range. By replacing the imaging filters by transmission-type dispersers on the filter wheels, it provides low-resolution (lambda/d_lambda ~ 20-120) spectroscopy with slits or in a wide imaging field-of-view (approximately 10'X10'). The IRC spectroscopic mode is unique in space infrared missions in that it has the capability to perform sensitive wide-field spectroscopic surveys in the near- and mid-infrared wavelength ranges. This paper describes specifications of the IRC spectrograph and its in-orbit performance.Comment: 13 pages, 7 figures, accepted for publication on PAS

AKARI infrared imaging of reflection nebulae IC4954 and IC4955

We present the observations of the reflection nebulae IC4954 and IC4955 region with the Infrared Camera (IRC) and the Far-Infrared Surveyor (FIS) on board the infrared astronomical satellite AKARI during its performance verification phase. We obtained 7 band images from 7 to 160um with higher spatial resolution and higher sensitivities than previous observations. The mid-infrared color of the S9W (9um) and L18W (18um) bands shows a systematic variation around the exciting sources. The spatial variation in the mid-infrared color suggests that the star-formation in IC4954/4955 is progressing from south-west to north-east. The FIS data also clearly resolve two nebulae for the first time in the far-infrared. The FIS 4-band data from 65um to 160um allow us to correctly estimate the total infrared luminosity from the region, which is about one sixth of the energy emitted from the existing stellar sources. Five candidates for young stellar objects have been detected as point sources for the first time in the 11um image. They are located in the red S9W to L18W color regions, suggesting that current star-formation has been triggered by previous star-formation activities. A wide area map of the size of about 1 x 1 (deg^2) around the IC4954/4955 region was created from the AKARI mid-infrared all-sky survey data. Together with the HI 21cm data, it suggests a large hollow structure of a degree scale, on whose edge the IC4954/4955 region has been created, indicating star formation over three generations in largely different spatial scales.Comment: 23 pages, 7 figures, accepted for publication in PASJ AKARI special issu

Requirement of Retinoic Acid Receptor β for Genipin Derivative-Induced Optic Nerve Regeneration in Adult Rat Retina

Like other CNS neurons, mature retinal ganglion cells (RGCs) are unable to regenerate their axons after nerve injury due to a diminished intrinsic regenerative capacity. One of the reasons why they lose the capacity for axon regeneration seems to be associated with a dramatic shift in RGCs\u27 program of gene expression by epigenetic modulation. We recently reported that (1R)-isoPropyloxygenipin (IPRG001), a genipin derivative, has both neuroprotective and neurite outgrowth activities in murine RGC-5 retinal precursor cells. These effects were both mediated by nitric oxide (NO)/S-nitrosylation signaling. Neuritogenic activity was mediated by S-nitrosylation of histone deacetylase-2 (HDAC2), which subsequently induced retinoic acid receptor β (RARβ) expression via chromatin remodeling in vitro. RARβ plays important roles of neural growth and differentiation in development. However, the role of RARβ expression during adult rat optic nerve regeneration is not clear. In the present study, we extended this hypothesis to examine optic nerve regeneration by IPRG001 in adult rat RGCs in vivo. We found a correlation between RARβ expression and neurite outgrowth with age in the developing rat retina. Moreover, we found that IPRG001 significantly induced RARβ expression in adult rat RGCs through the S-nitrosylation of HDAC2 processing mechanism. Concomitant with RARβ expression, adult rat RGCs displayed a regenerative capacity for optic axons in vivo by IPRG001 treatment. These neuritogenic effects of IPRG001 were specifically suppressed by siRNA for RARβ. Thus, the dual neuroprotective and neuritogenic actions of genipin via S-nitrosylation might offer a powerful therapeutic tool for the treatment of RGC degenerative disorders. © 2013 Koriyama et al