9 research outputs found
Engineering Validation and Engineering Design of Lithium Target Facility in IFMIF/EVEDA Project
No full textEnzymatic Generation of Highly Anticoagulant Bovine Intestinal Heparin
No full textUnlike
USP porcine heparin, bovine intestinal heparin (BIH) has
a low anticoagulant activity. Treatment with 6-OST-1, -3, and/or 3-OST-1
afforded two remodeled heparins that met USP heparin activity and
Mw specifications. We explored the pharmacodynamics and pharmacokinetics
in a rabbit model. We conclude that a modest increase in the content
of 3-<i>O</i>-sulfo groups in BIH increases the number of
antithrombin III binding sites, making remodeled BIH behave similarly
to pharmaceutical heparin
