THE INCIDENCE OF PEPTIC ULCER SURGERY BEFORE AND AFTER THE INTRODUCTION OF H2-RECEPTOR ANTAGONISTS

Since the introduction of H2-receptor antagonists, the incidence of ulcer surgery has decreased markedly. Based on the number of patients who underwent ulcer surgery and upper gastrointestinal endoscopy in our hospital, the number of operations for peptic ulcer disease has decreased, although the number of peptic ulcer patients diagnosed by endoscopy has increased after the introduction of cimetidine (the first H2-receptor antagonist in Japan). The decreasing rate of surgical therapy before and after the administration of H2-receptor antagonists was 49.1%. The number of emergency operations has also decreased among ulcer patients diagnosed by endoscopy although the number of perforated and bleeding ulcer patients has increased. It is also reported that the most common operative procedure for both gastric and duodenal ulcer was distal gastrectomy reconstructed by gastroduodenostomy (Billroth Ⅰ)

ガンセイ キョウマクエン カンジャ ニオケル OK-432 キョウクウ ナイ トウヨ ジ ノ ギョウコケイ ニ カンスル ケンキュウ : Fibrinogen チ ト キョウマク ユチャク トノ カンケイ

胸膜炎における胸膜癒着と, 血漿Fbg上昇との関係を明らかにする目的で, 癌性胸膜炎のOK-432胸腔内注入治療を行なった例を対象として下記の成績を得た。1.胸膜癒着像を残し, 2ヶ月間以上再貯留を認めなかった例(有効例)で, OK-432注入後血漿Fbg値は全例上昇し, 胸水中Fbg値は80%に上昇した。胸水Fbg値は血漿Fbg値より低値を示した。2.無効例では血漿および胸水Fbg値は注入後上昇は認められなかった。The effect of intrapleurally administered OK-432 on plasma on fibrinogen levels in cases with pleuritis carcinomatosa was examined. Plasma fibrinogen level was examined as a predictive index of pleural adhesion in cancerous pleuritis. Twelve cases with pleural effusion due to cancerous pleuritis were studied. Ten of 12 patients given OK-432 showed no accumulation of pleural fluid for 2 months and persistent pleural adhesion (effective). Eight cases showed a marked increase in plasma fibrinogen levels after OK-432 administration, while 8 showed a slight increase in fibrinogen levels in the pleural fluid. The 2 cases in whom no effect of OK-432 was recognized showed no significant change in fibrinogen level either in plasma or in the pleural fluid. The above mentioned findings revealed that elevated plasma fibrinogen level is a useful index to predict pleural adhesion in patients with inflammatory pleuritis

癌性胸膜炎患者におけるOK-432胸腔内投与時の凝固系に関する研究 : Fibrinogen値と胸膜癒着との関係

http://ci.nii.ac.jp/naid/110003126837application/pdf胸膜炎における胸膜癒着と, 血漿Fbg上昇との関係を明らかにする目的で, 癌性胸膜炎のOK-432胸腔内注入治療を行なった例を対象として下記の成績を得た。1.胸膜癒着像を残し, 2ヶ月間以上再貯留を認めなかった例(有効例)で, OK-432注入後血漿Fbg値は全例上昇し, 胸水中Fbg値は80%に上昇した。胸水Fbg値は血漿Fbg値より低値を示した。2.無効例では血漿および胸水Fbg値は注入後上昇は認められなかった。The effect of intrapleurally administered OK-432 on plasma on fibrinogen levels in cases with pleuritis carcinomatosa was examined. Plasma fibrinogen level was examined as a predictive index of pleural adhesion in cancerous pleuritis. Twelve cases with pleural effusion due to cancerous pleuritis were studied. Ten of 12 patients given OK-432 showed no accumulation of pleural fluid for 2 months and persistent pleural adhesion (effective). Eight cases showed a marked increase in plasma fibrinogen levels after OK-432 administration, while 8 showed a slight increase in fibrinogen levels in the pleural fluid. The 2 cases in whom no effect of OK-432 was recognized showed no significant change in fibrinogen level either in plasma or in the pleural fluid. The above mentioned findings revealed that elevated plasma fibrinogen level is a useful index to predict pleural adhesion in patients with inflammatory pleuritis

癌性胸膜炎患者におけるOK-432胸腔内投与時の凝固系に関する研究 : Fbg値と胸膜癒着との関係

http://ci.nii.ac.jp/naid/110003129333application/pd