The role of peptides in bone healing and regeneration: A systematic review

Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration. Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study. Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited. Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge

An epistemological critique of social entrepreneurship definitions

Abstract If entrepreneurship is amid jungle of theories and has many theorists, its social orientation or what is known as social entrepreneurship (SE) is amid arid land of theories and suffers under-theorizing which could be inherently stemmed from its diversely proposed definitions. To be situated in an embryonic pre-paradigmatic phase, getting to a more unanimous definition in this realm is the first step in laying a solid foundation for SE theorizing. As a pioneering study, the paper aims to investigate the epistemological foundations of SE definitions critically to propose a more convergent definition for SE. To fulfill this goal epistemological justifications for the definitional components of SE are presented. Therefore, it was necessary to rely on the relevant philosophical schools of thought in Epistemology (e.g. Empiricism, Internalism, Externalism, Verificationism and Falsificationism); first to discuss the controversies and oppositions to some components of the definitions for their exclusion and then to justify some other definitional components which are mostly accepted by the scholars for their inclusion in a final SE definition. Critical approach has helped us in specifying the maneuvering of thoughts in this field and determining the epistemological and definitional boundaries of SE. Finally, a more epistemologically-supported and justified definition was presented at the end of the paper. Moreover, one of the potential contributions of this paper could be its consensus-making impact among SE scholars in defining SE phenomenon, which could also pave the way for future theorizing in SE. The originality of the paper lies in the application of Internalism, Externalism, Verificationism and Falsificationism concepts to SE definitions