Anti-ganglioside antibodies in peripheral nerve pathology

Anti-ganglioside antibodies are principally associated with autoimmune peripheral neuropathies. In these disorders, immune attack is inadvertently directed at peripheral nerve by autoantibodies that target glycan structures borne by glycolipids, particularly gangliosides concentrated in nerve myelin and axons. The most thoroughly studied disorder is the acute paralytic disease, Guillain-Barré syndrome (GBS) in which IgG autoantibodies against gangliosides arise following acute infections, notably Campylobacter jejuni enteritis. Additionally, chronic autoimmune neuropathies are associated with IgM antibodies directed against many glycolipids including gangliosides. This introductory chapter briefly summarizes the immunological and pathological features of these disorders, focusing on the methodological development of antibody measurement and of animal models

Adenovirus type 21-associated acute flaccid paralysis during an outbreak of hand-foot-and-mouth disease in Sarawak, Malaysia

We report the virological and clinical features of 8 children who presented with adenovirus-associated acute flaccid paralysis (AFP) during an epidemic of enterovirus type 71 (EV71)-associated hand-foot-and-mouth disease (HFMD) in Sarawak, Malaysia, in 1997. Neutralization tests and phylogenetic analysis revealed adenovirus type 21 (Ad21), although DNA restriction digests suggested that this virus was different from the prototype Ad21. Four children had upper-limb monoparesis, 2 had lower-limb monoparesis (one of whom had changes in the anterior spinal cord noted on magnetic resonance imaging), and 2 had flaccid paraparesis. At follow-up, 4 children were noted to have made full recoveries and 3 had residual flaccid weakness and wasting. Neurophysiological investigation revealed a mixture of axonal and demyelinating features in motor and sensory nerves, with denervation. These findings suggest that Ad21 might cause AFP by anterior horn cell damage or neuropathy of the brachial or lumbosacral plexus. The occurrence of these unusual adenovirus infections during an outbreak of EV71-associated HFMD suggests that an interaction between the 2 viruses may have occurred

Religious Beliefs, Religious Contexts, and Perceived Interactions with Ex-Offenders

Religious institutions can provide a means of support and resources for many people, particularly, individuals who have criminal histories, specifically parolees, sex offenders, and insanity acquittees. When these individuals are released into the community, they often face difficulties in acquiring shelter, work, and social support. Out of their own volition or as a result of faith-based prison programs, they might turn to religious institutions for help reintegrating into the community. However, whether congregation members are more or less accepting of these individuals is unaddressed in the current literature. Two studies assess the relationship between religious beliefs, religious contexts, legal attitudes, and perceived social interactions with parolees, sex offenders, and insanity acquittees. Results suggest that religious beliefs, legal attitudes, and religious contexts play an important role in individuals’ perceived interactions with these individuals. Religious contexts, specifically, might facilitate more positive social interactions with parolees. Implications are discussed