7 research outputs found
Mutagenesis of Lysines 156 and 159 in Human Immunodeficiency Virus Type 1 Integrase (IN) Reveals Differential Interactions between these Residues and Different IN Inhibitors
No full textExpression and coassociation of ERG1, KCNQ1, and KCNE1 potassium channel proteins in horse heart
No full textComparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels
No full textSlow Delayed Rectifier Potassium Current (IKs) and the Repolarization Reserve
No full textThe aim of this review is to present the properties of the slow component of the delayed rectifier potassium current (I-Ks) in the human ventricle. The review gives a detailed description of the physiology, molecular biology and pharmacology of the I-Ks current, including kinetic properties, genetic structures, agonists and antagonists. The authors also present the role of the I-Ks current in the human cardiac repolarization focusing on several pathophysiological situations, such as the LQT syndrome and the Torsade de Pointes arrhythmia
