49 research outputs found
A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance - the T Mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program
T mapping and extracellular volume (ECV) have the potential to guide patient care and serve as surrogate end-points in clinical trials, but measurements differ between cardiovascular magnetic resonance (CMR) scanners and pulse sequences. To help deliver T mapping to global clinical care, we developed a phantom-based quality assurance (QA) system for verification of measurement stability over time at individual sites, with further aims of generalization of results across sites, vendor systems, software versions and imaging sequences. We thus created T1MES: The T1 Mapping and ECV Standardization Program.
A design collaboration consisting of a specialist MRI small-medium enterprise, clinicians, physicists and national metrology institutes was formed. A phantom was designed covering clinically relevant ranges of T and T in blood and myocardium, pre and post-contrast, for 1.5 T and 3 T. Reproducible mass manufacture was established. The device received regulatory clearance by the Food and Drug Administration (FDA) and Conformité Européene (CE) marking.
The T1MES phantom is an agarose gel-based phantom using nickel chloride as the paramagnetic relaxation modifier. It was reproducibly specified and mass-produced with a rigorously repeatable process. Each phantom contains nine differently-doped agarose gel tubes embedded in a gel/beads matrix. Phantoms were free of air bubbles and susceptibility artifacts at both field strengths and T maps were free from off-resonance artifacts. The incorporation of high-density polyethylene beads in the main gel fill was effective at flattening the field. T and T values measured in T1MES showed coefficients of variation of 1 % or less between repeat scans indicating good short-term reproducibility. Temperature dependency experiments confirmed that over the range 15-30 °C the short-T tubes were more stable with temperature than the long-T tubes. A batch of 69 phantoms was mass-produced with random sampling of ten of these showing coefficients of variations for T of 0.64 ± 0.45 % and 0.49 ± 0.34 % at 1.5 T and 3 T respectively.
The T1MES program has developed a T mapping phantom to CE/FDA manufacturing standards. An initial 69 phantoms with a multi-vendor user manual are now being scanned fortnightly in centers worldwide. Future results will explore T mapping sequences, platform performance, stability and the potential for standardization.This project has been funded by a European Association of Cardiovascular Imaging (EACVI part of the ESC) Imaging Research Grant, a UK National Institute of Health Research (NIHR) Biomedical Research Center (BRC) Cardiometabolic Research Grant at University College London (UCL, #BRC/ 199/JM/101320), and a Barts Charity Research Grant (#1107/2356/MRC0140). G.C. is supported by the National Institute for Health Research Rare Diseases Translational Research Collaboration (NIHR RD-TRC) and by the NIHR UCL Hospitals Biomedical Research Center. J.C.M. is directly and indirectly supported by the UCL Hospitals NIHR BRC and Biomedical Research Unit at Barts Hospital respectively. This work was in part supported by an NIHR BRC award to Cambridge University Hospitals NHS Foundation Trust and NIHR Cardiovascular Biomedical Research Unit support at Royal Brompton Hospital London UK
A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance—the T1 Mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program
ENHANCEMENT OF SUPERCONDUCTIVITY FAR ABOVE THE CRITICAL-TEMPERATURE IN DOUBLE-BARRIER TUNNEL-JUNCTIONS
Motivated by the observation of a superconducting energy gap far above the equilibrium critical temperature T(c) in an Al film forming the center electrode of a Nb/AlO(x)/Al/AlO(x)/Nb structure we analyze the mechanism of gap enhancement in symmetric double-barrier superconducting tunnel junctions. It is found that such structures are very effective in creating a nonthermal distribution of quasiparticles in the middle electrode. At certain bias conditions this leads, according to the BCS gap equation, to the appearance of a nonzero superconducting energy gap even at temperatures up to several times the equilibrium T(c). So the double-barrier arrangement offers the remarkable possibility of making a material become superconducting by applying a voltage or passing a current. Calculated current-voltage characteristics exhibit current steps at voltages eV=2(DELTA(Nb)-DELTA(Al)) and eV=2(DELTA(Nb)+DELTA(Al)) in agreement with measured curves. Calculations of the thermodynamic stability of the nonequilibrium superconducting state indicate the possibility of hysteresis effects around these current steps
INELASTIC-SCATTERING TIMES IN METALLIC SI-P AT LOW-TEMPERATURES
The inelastic lifetime tau(in) in 3-dimensional Si:P layers with doping far above the metal-insulator transition is determined from the weak localization correction to the magnetoresistance in the temperature range of 1.2-4.8 K. Electron-electron interaction effects show up weakly at high magnetic fields and low temperatures. The inelastic scattering rate is determined as tau(in)-1=1.1x10(9)xT2.2. The relative contribution of electron-electron and electron-phonon scattering is discussed