244 research outputs found
Symmetric inverse consistent nonlinear registration driven by mutual information.
A nonlinear viscoelastic image registration algorithm based on the demons paradigm and incorporating inverse consistent constraint (ICC) is implemented. An inverse consistent and symmetric cost function using mutual information (MI) as a similarity measure is employed. The cost function also includes regularization of transformation and inverse consistent error (ICE). The uncertainties in balancing various terms in the cost function are avoided by alternatively minimizing the similarity measure, the regularization of the transformation, and the ICE terms. The diffeomorphism of registration for preventing folding and/or tearing in the deformation is achieved by the composition scheme. The quality of image registration is first demonstrated by constructing brain atlas from 20 adult brains (age range 30-60). It is shown that with this registration technique: (1) the Jacobian determinant is positive for all voxels and (2) the average ICE is around 0.004 voxels with a maximum value below 0.1 voxels. Further, the deformation-based segmentation on Internet Brain Segmentation Repository, a publicly available dataset, has yielded high Dice similarity index (DSI) of 94.7% for the cerebellum and 74.7% for the hippocampus, attesting to the quality of our registration method
Generalized fuzzy clustering for segmentation of multi-spectral magnetic resonance images.
An integrated approach for multi-spectral segmentation of MR images is presented. This method is based on the fuzzy c-means (FCM) and includes bias field correction and contextual constraints over spatial intensity distribution and accounts for the non-spherical cluster\u27s shape in the feature space. The bias field is modeled as a linear combination of smooth polynomial basis functions for fast computation in the clustering iterations. Regularization terms for the neighborhood continuity of intensity are added into the FCM cost functions. To reduce the computational complexity, the contextual regularizations are separated from the clustering iterations. Since the feature space is not isotropic, distance measure adopted in Gustafson-Kessel (G-K) algorithm is used instead of the Euclidean distance, to account for the non-spherical shape of the clusters in the feature space. These algorithms are quantitatively evaluated on MR brain images using the similarity measures
Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways
Volume and shape in feature space on adaptive FCM in MRI segmentation.
Intensity non-uniformity (bias field) correction, contextual constraints over spatial intensity distribution and non-spherical cluster\u27s shape in the feature space are incorporated into the fuzzy c-means (FCM) for segmentation of three-dimensional multi-spectral MR images. The bias field is modeled by a linear combination of smooth polynomial basis functions for fast computation in the clustering iterations. Regularization terms for the neighborhood continuity of either intensity or membership are added into the FCM cost functions. Since the feature space is not isotropic, distance measures, other than the Euclidean distance, are used to account for the shape and volumetric effects of clusters in the feature space. The performance of segmentation is improved by combining the adaptive FCM scheme with the criteria used in Gustafson-Kessel (G-K) and Gath-Geva (G-G) algorithms through the inclusion of the cluster scatter measure. The performance of this integrated approach is quantitatively evaluated on normal MR brain images using the similarity measures. The improvement in the quality of segmentation obtained with our method is also demonstrated by comparing our results with those produced by FSL (FMRIB Software Library), a software package that is commonly used for tissue classification
AT: Alignment-Aware Acoustic and Text Pretraining for Speech Synthesis and Editing
Recently, speech representation learning has improved many speech-related
tasks such as speech recognition, speech classification, and speech-to-text
translation. However, all the above tasks are in the direction of speech
understanding, but for the inverse direction, speech synthesis, the potential
of representation learning is yet to be realized, due to the challenging nature
of generating high-quality speech. To address this problem, we propose our
framework, Alignment-Aware Acoustic-Text Pretraining (AT), which
reconstructs masked acoustic signals with text input and acoustic-text
alignment during training. In this way, the pretrained model can generate high
quality of reconstructed spectrogram, which can be applied to the speech
editing and unseen speaker TTS directly. Experiments show AT outperforms
SOTA models on speech editing, and improves multi-speaker speech synthesis
without the external speaker verification model.Comment: under review, 12 pages, 10 figure
PCDNF: Revisiting Learning-based Point Cloud Denoising via Joint Normal Filtering
Recovering high quality surfaces from noisy point clouds, known as point
cloud denoising, is a fundamental yet challenging problem in geometry
processing. Most of the existing methods either directly denoise the noisy
input or filter raw normals followed by updating point positions. Motivated by
the essential interplay between point cloud denoising and normal filtering, we
revisit point cloud denoising from a multitask perspective, and propose an
end-to-end network, named PCDNF, to denoise point clouds via joint normal
filtering. In particular, we introduce an auxiliary normal filtering task to
help the overall network remove noise more effectively while preserving
geometric features more accurately. In addition to the overall architecture,
our network has two novel modules. On one hand, to improve noise removal
performance, we design a shape-aware selector to construct the latent tangent
space representation of the specific point by comprehensively considering the
learned point and normal features and geometry priors. On the other hand, point
features are more suitable for describing geometric details, and normal
features are more conducive for representing geometric structures (e.g., sharp
edges and corners). Combining point and normal features allows us to overcome
their weaknesses. Thus, we design a feature refinement module to fuse point and
normal features for better recovering geometric information. Extensive
evaluations, comparisons, and ablation studies demonstrate that the proposed
method outperforms state-of-the-arts for both point cloud denoising and normal
filtering
Prognostic nomogram for bladder cancer with brain metastases: a National Cancer Database analysis.
BACKGROUND: This study aimed to establish and validate a nomogram for predicting brain metastasis in patients with bladder cancer (BCa) and assess various treatment modalities using a primary cohort comprising 234 patients with clinicopathologically-confirmed BCa from 2004 to 2015 in the National Cancer Database.
METHODS: Machine learning method and Cox model were used for nomogram construction. For BCa patients with brain metastasis, surgery of the primary site, chemotherapy, radiation therapy, palliative care, brain confinement of metastatic sites, and the Charlson/Deyo Score were predictive features identified for building the nomogram.
RESULTS: For the original 169 patients considered in the model, the areas under the receiver operating characteristic curve (AUC) were 0.823 (95% CI 0.758-0.889, P \u3c 0.001) and 0.854 (95% CI 0.785-0.924, P \u3c 0.001) for 0.5- and 1-year overall survival respectively. In the validation cohort, the nomogram displayed similar AUCs of 0.838 (95% CI 0.738-0.937, P \u3c 0.001) and 0.809 (95% CI 0.680-0.939, P \u3c 0.001), respectively. The high and low risk groups had median survivals of 1.91 and 5.09 months for the training cohort and 1.68 and 8.05 months for the validation set, respectively (both P \u3c 0.0001).
CONCLUSIONS: Our prognostic nomogram provides a useful tool for overall survival prediction as well as assessing the risk and optimal treatment for BCa patients with brain metastasis
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