Visual impairment from fibrous dysplasia in a middle-aged African man: a case report

<p>Abstract</p> <p>Introduction</p> <p>Fibrous dysplasia is a benign tumour of the bones and is a disease of unknown aetiology. This report discusses a case of proptosis and visual deterioration with associated bony mass involving the right orbit.</p> <p>Case presentation</p> <p>A 32-year-old Nigerian man of Yoruba ethnic origin presented to the eye clinic of our hospital with right-eye proptosis and visual deterioration of 7-year duration. Presentation was preceded by a history of trauma. Proptosis was preceded by trauma but was non-pulsatile with no thrill or bruit but was associated with bony orbital mass. The patient reported no weight loss. Examination of his right eye showed visual acuity of 6/60 with relative afferent pupillary defect. Fundal examination revealed optic atrophy. Computed tomography showed an expansile bony mass involving all the walls of the orbit. The bony orbital mass was diagnosed histologically as fibrous dysplasia. Treatment included orbital exploration and orbital shaping to create room for the globe and relieve pressure on the optic nerve.</p> <p>Conclusion</p> <p>Fibrous dysplasia should be considered in the differential diagnosis of slowly developing proptosis with associated visual loss in young adults.</p

A Model of Salmonella Colitis with Features of Diarrhea in SLC11A1 Wild-Type Mice

Background: Mice do not get diarrhea when orally infected with S. enterica, but pre-treatment with oral aminoglycosides makes them susceptible to Salmonella colitis. However, genetically susceptible ItyS mice (Nramp1 G169D allele) die from systemic infection before they develop diarrhea, so a new model is needed to study the pathogenesis of diarrhea. We pretreated ItyR mice (Nramp1 G169) with oral kanamycin prior to infecting them with virulent S. Typhimurium strain 14028s in order to study Salmonella-induced diarrhea. We used both a visual scoring system and the measurement of fecal water content to measure diarrhea. BALB/c.D2 Nramp1 congenic started losing weight 5 days post-infection and they began to die from colitis 10–14 days after infection. A SPI-1 (invA) mutant caused cecal, but not colonic inflammation and did not cause diarrhea. A phoP- mutant did not cause manifestations of diarrhea in either normal or NADPHdeficient (gp91 phox) mice. However, strain 14028s caused severe colitis and diarrhea in gp91 phox-deficient mice on an ItyR background. pmr A and F mutants, which are less virulent in orally infected BALB/c mice, were fully virulent in this model of colitis. Conclusions: S. enterica must be able to invade the colonic epithelium and to persist in the colon in order to cause colitis with manifestations of diarrhea. The NADPH oxidase is not required for diarrhea in Salmonella colitis. Furthermore,

Onderzoek naar een kinkhoest-epidemie in de provincie Bam, Burkino Faso, januari 1991

Abstract niet beschikbaarA localized outbreak of pertussis in a part of the Bam province, Burkino Faso (West Africa) has been investigated in order to confirm the clinical diagnosis with laboratory methods, and to study the protective efficacy of the vaccine. In the affected area childhood immunization are given according to a simplified vaccination schedule with only two doses of a quadruple DTCP (DPT-IPV) vaccine (against diphteria, tetanus, pertussis and poliomyelitis). A total of 115 children was studied (interview, serology, classical culture, PCR test). The clinical diagnosis could be confirmed in a number of children by serology. Among children of 5 years and older some had received two DTCP caccinations. Younger children seemed to be protected better against pertussis. The numbers of children studied are too small however for a precise estimate of pertussis vaccin efficacy in this particular immunization program with simplified schedule.RIV

Serologische evaluatie van een vereenvoudigd immunisatie schema in Burkina Faso. Rapport van een samenwerkingsproject uitgevoerd in april 1989

Abstract niet beschikbaarA cross-sectional serological survey involving 355 children was performed to study the immunogenicity of DPT-IPV vaccine and measles vaccine under tropical conditions. The vaccines were used in the EPI programme in three provinces in Burkina Faso, West-Africa. A two dose regimen is followed for DPT-IPV. A very high percentage of the group of 179 twice vaccinated children was antibody positive. In the 176 non-vaccinated children a substantial proportion had antibodies to polioviruses, most of them only to one type. This appears to be a sensitive parameter for the circulation of wild polio viruses in the environment.RIV