291 research outputs found
Using the Sum of Roots and Its Application to a Control Design Problem
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<Abstract of Published Report>Nitric oxide and its decomposed derivatives decrease the binding of extracellular-superoxide dismutase to the endothelial cell surface.
<Abstract of Published Report>The students\u27 awareness about practical training in community prescription pharmacy.
<Abstract of Published Report>Effects of Homocysteine on the Binding of Extracellular-Superoxide Dismutase to the Endothelial Cell Surface.
<Abstract of Published Report>Heparin-affinity of human extracellular-superoxide dismutase in the brain.
<Abstract of Published Report>Inhibitory Effect of Nitric Oxide on the Induction of Cytochrome P450 3A4 mRNA by 1,25-Dihydroxyvitamin D_3in Caco-2 cells.
<Abstract of Published Report>Enhancement of Glucuronosyl Etoposide Transport by Glutathione in Multidrug Resistance-Associated Protein-Overexpressing Cells.
Isorhamnetin activates lysosomes in J774.1 macrophages.
Lysosome is the principal organelle for the ultimate degradation of cellular macromolecules, which are delivered through endocytosis, phagocytosis and autophagy. The lysosomal functions have been found to be impaired by fatty foods and aging, and more importantly, the lysosomal dysfunction in macrophages has been reported as a risk of atherosclerosis development. In this study, we searched for dietary polyphenols which possess the activity for enhancing the lysosomal degradation in J774.1, a murine macrophage-like cell line. Screening test utilizing DQ-BSA digestion identified isorhamnetin (3’-O-methylquercetin) as an active compound. Interestingly, structural comparison to inactive flavonols revealed that the chemical structure of the B-ring moiety in isorhamnetin is the primary determinant of its lysosome-enhancing activity. Unexpectedly isorhamnetin failed to inhibit mTORC1-TFEB signaling, a master regulator of lysosomal biogenesis and function. Our data suggested that the other molecular mechanism might be critical for the regulation of lysosomes in macrophages
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