Maturity Onset Diabetes of the Young (MODY)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147788/1/dme199613s690.pd

The core of sibling stem cell donation-A grounded theory study

Background: There is a lack of theoretical framework supporting stem cell transplant nurses in their assessment, judgment and caring interventions of sibling stem cell donors. Objective: The purpose of this study was to explore sibling stem cell donors’ main concerns and how they deal with them before and after donation. Method: Ten healthy sibling donors, 5 men and 5 women, with a median age of 54 years were included in this study when they were due to donate stem cells to a brother or sister. Data were collected prospectively on three occasions (before the donation and three and twelve months after it) through in-depth interviews, which were recorded and transcribed verbatim for analysis by the Grounded Theory method according to Charmaz. Results: This study describes the efforts of the ten donors to fulfil their duty as a sibling by doing what they considered necessary in order to help. Their efforts were summarised in a process wherein the grounded theory generated three main categories; Prepare, Promote and Preserve. A clear path of transition leading to fulfilment is evident, starting before the donation and continuing for one year afterwards. Conclusions: Being a sibling stem cell donor means doing what you have to do to fulfil your duty and if possible, saving the life of a seriously ill brother or sister. The relationship between the siblings is strengthened by the donation process. Sibling stem cell donation appears to be about fulfilment and the theoretical framework may support clinicians in their evaluation and support of donors

Measurements of the three-dimensional structure of flames at low turbulence

The development of spark-ignited flame kernels in a turbulent field is strongly dependent upon the nature of the three-dimensional (3-D) turbulence adjacent to the ignition source. The turbulence scales vary in 3-D from shot to shot, resulting in successive flame kernels developing differently and thereby causing cyclic variations in, for example, spark ignition engines. It is necessary to quantify the scales affecting the flame at any instant for the accurate measurement of burn rate of such flame kernels, which requires visualization of the flame surface in 3-D. The experiments reported here employ a multiple sheet mie-scattered light technique to successfully characterize a nonstabilized expanding turbulent flame kernel in 3-D. A novel algorithm was developed to construct the flame surface in 3-D, which enabled accurate calculation of parameters such as flame surface density, reaction progress variables, and turbulent flame thickness