262 research outputs found
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MELCOR aerosol transport module modification for NSSR-1
This report describes modifications of the MELCOR computer code aerosol transport module that will increase the accuracy of calculations for safety analysis of the International Thermonuclear Experimental Reactor (ITER). The modifications generalize aerosol deposition models to consider gases other than air, add specialized models for aerosol deposition during high speed gas flows in ducts, and add models for resuspension of aerosols that are entrained in coolants when these coolants flash. Particular attention has been paid to the adhesion of aerosol particles once they are transported to duct walls. The results of calculations with the modified models have been successfully compared to data from Light Water Reactor Aerosol Containment Experiments (LACE) conducted by an international consortium at Hanford, Washington
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Behavior of four PWR rods subjected to a simulated loss-of-coolant accient in the power burst facility
Cladding deformation characteristics resulting from the first nuclear blowdown tests (LOC-11) conducted in the Power Burst Facility (PBF) are emphasized in this paper. The objective of the LOC-11 tests was to obtain data on the thermal, mechanical, and materials behavior of pressurized and unpressurized fuel rods when exposed to a blowdown similiar to that expected in a pressurized water reactor (PWR) during a hypothesized double-ended cold-leg break. The test hardware consisted of four separately shrouded fresh fuel rods of PWR 15 x 15 design. Initial plenum pressures ranged from atmospheric to 4.8 MPa (representative of end-of-life). During LOC-11C, the four fuel rods were subjected to 6.5 hours of nuclear operation at approximately 67 kW/m average rod power to cause decay heat build-up. Just before the start of blowdown, cladding surface temperatures were about 620 K and fuel centerline temperatures were in the 2500 to 2600 K range. During the 30-second blowdown transient, CHF occurred 2 seconds after initiation. Fuel centerline temperature dropped continuously, while cladding surface temperatures increased. Maximum cladding temperatures of 1030 to 1050 K occurred 15 seconds into the transient. Posttest destructive examination revealed cladding microstructures and oxide thicknesses consistent with the measured cladding temperatures. The cladding surface thermocouples did not appreciably affect cladding temperature distributuion (fin cooling effect) in the vicinity of the thermocouples
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In situ vitrification model development and implementation plan
This document describes the In Situ Vitrification (ISV) Analysis Package being developed at the INEL to provide analytical support for (ISV) safety analysis and treatment performance predictions. Mathematical models and features which comprise this analysis package are presented and the proposed approach to model development and implementation is outlined. The objective of this document is two fold: to define preliminary design information and modeling objectives so that ISV modeling personnel can effectively modify existing models and formulate new models which are consistent with the objectives of the ISV treatability study and to provide sufficient technical information for internal and external reviewers to detect any shortcomings in model development and implementation plans. 27 refs., 17 figs., 3 tabs
Glutathione <em>S</em>-transferase P1 (<em>GSTP1</em>) directly influences platinum drug chemosensitivity in ovarian tumour cell lines
BACKGROUND: Chemotherapy response in ovarian cancer patients is frequently compromised by drug resistance, possibly due to altered drug metabolism. Platinum drugs are metabolised by glutathione S-transferase P1 (GSTP1), which is abundantly, but variably expressed in ovarian tumours. We have created novel ovarian tumour cell line models to investigate the extent to which differential GSTP1 expression influences chemosensitivity. METHODS: Glutathione S-transferase P1 was stably deleted in A2780 and expression significantly reduced in cisplatin-resistant A2780DPP cells using Mission shRNA constructs, and MTT assays used to compare chemosensitivity to chemotherapy drugs used to treat ovarian cancer. Differentially expressed genes in GSTP1 knockdown cells were identified by Illumina HT-12 expression arrays and qRT–PCR analysis, and altered pathways predicted by MetaCore (GeneGo) analysis. Cell cycle changes were assessed by FACS analysis of PI-labelled cells and invasion and migration compared in quantitative Boyden chamber-based assays. RESULTS: Glutathione S-transferase P1 knockdown selectively influenced cisplatin and carboplatin chemosensitivity (2.3- and 4.83-fold change in IC(50), respectively). Cell cycle progression was unaffected, but cell invasion and migration was significantly reduced. We identified several novel GSTP1 target genes and candidate platinum chemotherapy response biomarkers. CONCLUSIONS: Glutathione S-transferase P1 has an important role in cisplatin and carboplatin metabolism in ovarian cancer cells. Inter-tumour differences in GSTP1 expression may therefore influence response to platinum-based chemotherapy in ovarian cancer patients
Three-dimensional lanthanide-organic frameworks based on di-, tetra-, and hexameric clusters
Three-dimensional lanthanide-organic frameworks formulated as (CH3)2NH2[Ln(pydc)2] · 1/2H2O [Ln3+ ) Eu3+ (1a)
or Er3+ (1b); pydc2- corresponds to the diprotonated residue of 2,5-pyridinedicarboxylic acid (H2pydc)], [Er4(OH)4(pydc)4(H2O)3] ·H2O
(2), and [PrIII
2PrIV
1.25O(OH)3(pydc)3] (3) have been isolated from typical solvothermal (1a and 1b in N,N-dimethylformamide -
DMF) and hydrothermal (2 and 3) syntheses. Materials were characterized in the solid state using single-crystal X-ray diffraction,
thermogravimetric analysis, vibrational spectroscopy (FT-IR and FT-Raman), electron microscopy, and CHN elemental analysis.
While synthesis in DMF promotes the formation of centrosymmetric dimeric units, which act as building blocks in the construction
of anionic ∞
3{[Ln(pydc)2]-} frameworks having the channels filled by the charge-balancing (CH3)2NH2
+ cations generated in situ by
the solvolysis of DMF, the use of water as the solvent medium promotes clustering of the lanthanide centers: structures of 2 and 3
contain instead tetrameric [Er4(μ3-OH)4]8+ and hexameric |Pr6(μ3-O)2(μ3-OH)6| clusters which act as the building blocks of the networks,
and are bridged by the H2-xpydcx- residues. It is demonstrated that this modular approach is reflected in the topological nature of
the materials inducing 4-, 8-, and 14-connected uninodal networks (the nodes being the centers of gravity of the clusters) with
topologies identical to those of diamond (family 1), and framework types bct (for 2) and bcu-x (for 3), respectively. The
thermogravimetric studies of compound 3 further reveal a significant weight increase between ambient temperature and 450 °C with
this being correlated with the uptake of oxygen from the surrounding environment by the praseodymium oxide inorganic core
Code Development and Analysis Program: cladding mechanical limits (CMLIMT)
Revised models are described for cladding mechanical limits. The update incorporates important new data from several Nuclear Regulatory Commission and German experimental programs and defines a single physically reasonable failure criterion for cladding under tensile stress. Alternate simplified expressions are also derived for use in obtaining estimates of typical cladding shape after burst
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FRAP-GCFR: a code for the transient analysis of gas-cooled fast reactors
The fuel rod analysis computer program (FRAP-T) has been modified to analyze transient fuel rod behavior in the gas cooled fast reactor (GCFR). Major features modeled include the effects of helium coolant, ribbed cladding, pressure equalization system, and 316 stainless-steel material properties. The code capabilities include models of elastic-plastic-creep deformation behavior, two-dimensional heat conduction, rod ballooning, and transient axial gas flow. The models are particularly relevant to GCFR transient analysis in that partial or full blockage of the pressure equalization system could cause a significant pressure differential to exist during a helium depressurization, the GCFR design basis accident. An analysis of the design basis accident illustrating the predictive capabilities of the code is presented
Ligand Influences on Copper Molybdate Networks: The Structures and Magnetism of [Cu(3,4‘-bpy)MoO 4
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Volatilization from PCA steel alloy
The mobilizations of key components from Primary Candidate Alloy (PCA) steel alloy have been measured with laboratory-scale experiments. The experiments indicate most of the mobilization from PCA steel is due to oxide formation and spalling but that the spalled particles are large enough to settle rapidly. Based on the experiments, models for the volatization of iron, manganese, and cobalt from PCA steel in steam and molybdenum from PCA steel in air have been derived
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