Identification of Physiologically Active Substances as Novel Ligands for MRGPRD

Mas-related G-protein coupled receptor member D (MRGPRD) is a G protein-coupled receptor (GPCR) which belongs to the Mas-related GPCRs expressed in the dorsal root ganglia (DRG). In this study, we investigated two novel ligands in addition to beta-alanine: (1) beta-aminoisobutyric acid, a physiologically active substance, with which possible relation to tumors has been seen together with beta-alanine; (2) diethylstilbestrol, a synthetic estrogen hormone. In addition to the novel ligands, we found that transfection of MRGPRD leads fibroblast cells to form spheroids, which would be related to oncogenicity. To understand the MRGPRD novel character, oncogenicity, a large chemical library was screened in order to obtain MRGPRD antagonists to utilize in exploring the character. The antagonist in turn inhibited the spheroid proliferation that is dependent on MRGPRD signaling as well as MRGPRD signals activated by beta-alanine. The antagonist, a small-molecule compound we found in this study, is a potential anticancer agent

Trial of low temperature control method for library materials

24年5月のシバンムシ発生以降，懸案となっていた資料の殺虫方法について検討し，冷凍庫を使用した低温殺虫法を導入することとした．本稿では導入の経緯・検討過程と作業実施内容について報告する

Biological Damages and Measures to Prevent Damages in Central Library : Mainly about the Damages of Deathwatch Beetle

24年5月，中央図書館修復室においてシバンムシの発生が確認された．本稿ではこの問題の経緯と対処について，またこれを機として開始した調査と対策について報告する

図書館資料に対する低温殺虫法の試行

24年5月のシバンムシ発生以降，懸案となっていた資料の殺虫方法について検討し，冷凍庫を使用した低温殺虫法を導入することとした．本稿では導入の経緯・検討過程と作業実施内容について報告する

A Report of the symposium “The Heritage Books and Documents: TheirTreatment & Conservation”

2009年12月5-6日に奈良県立図書情報館で行われたシンポジウム「歴史遺産としての古典資料の保存修復」について報告する

Report of the courses by Center for Historical Social Science Literature, Hitotsubashi University

一橋大学社会科学古典資料センターが開催している西洋古典資料保存講習会，西洋社会科学古典資料講習会の両講習会について紹介する

シンポジウム「歴史遺産としての古典資料の保存修復」に参加して

2009年12月5-6日に奈良県立図書情報館で行われたシンポジウム「歴史遺産としての古典資料の保存修復」について報告する

Factors and Challenges in Increasing the Utilization Rate of a New Long-term Care Service (Kantaki) in a Superaging Society: Cross-sectional Study

BackgroundJapan is a superaging society unparalleled in the world. Elderly people who need medical care do not receive adequate support in the community. As a new service to address this issue, a small-scale multifunctional in-home care nursing service called Kantaki was created in 2012. Kantaki, in collaboration with a primary physician, operates 24 hours a day and provides various nursing services (home visits, home care, day care, and overnight stays) to older people living in the community. The Japanese Nursing Association is working hard to promote this system; however, its low utilization rate is an issue. ObjectiveThis study aimed to determine factors influencing the utilization rate of Kantaki facilities. MethodsThis was a cross-sectional study. A questionnaire on the operation of Kantaki was sent to all administrators of Kantaki facilities operating in Japan from October 1 to December 31, 2020. A multiple regression analysis was used to determine factors associated with a high utilization rate. ResultsResponses from 154 of the 593 facilities were analyzed. The average utilization rate for all valid responding facilities was 79.4%. The average number of actual users and the break-even point were almost equal, resulting in little surplus profit from facility operations. A multiple regression analysis showed that factors that had a significant impact on the utilization rate included the break-even point, a surplus of users relative to the break-even point (ie, the margin of revenues), the number of months in office of the administrator, the type of corporation (ie, nonprofit), and Kantaki’s profit from operating home-visit nursing offices. The break-even point, a surplus of users relative to the break-even point, and the number of months in office of the administrator were robust. In addition, support for reducing the burden on family helpers, a service sought by the system, significantly and negatively affected the utilization rate. In the analysis that removed the most influential factors, the cooperation of the home-visit nursing office, Kantaki’s profit from operating the home-visit nursing office, and the number of full-time care workers were significantly related. ConclusionsTo improve the utilization rate, managers need to stabilize their organization and increase profitability. However, a positive relationship was found between the break-even point and utilization rate, suggesting that simply increasing users did not contribute to cost reduction. Moreover, providing services that meet the needs of individual clients may result in lower utilization rates. These results, which are inconsistent with common sense, reflect the divergence between the assumptions underlying the system’s design and actual conditions. To solve these issues, institutional reforms, such as an increase in nursing care fee points, may be necessary

A report of editing and issuing the first edition of \u22Guidelines for preservation in libraries: how to use and care of library materials\u22

2001～2004年に活動した資料保存研修会で編集途上であった「資料保存ガイドライン」を，2008年度に新たに設置された研究開発事項「資料保存に関する調査研究」の取り組みとして再編集し，初版を公表するまでの経緯を報告する

「図書館における資料保存のためのガイドライン : 図書館資料の利用と保存のために」初版公表まで

2001～2004年に活動した資料保存研修会で編集途上であった「資料保存ガイドライン」を，2008年度に新たに設置された研究開発事項「資料保存に関する調査研究」の取り組みとして再編集し，初版を公表するまでの経緯を報告する