PROVISION CAPACITY OF SERVICE DELIVERY FACILITIES FOR CHILDREN WITH HEARING LOSS IN HAI PHONG, VIETNAM

Objective: Hearing loss is a commonly occurring disability that affects 466 million people worldwide. This study aimed at determining the actual situations of early intervention delivery facilities for children with hearing loss. Out of this affected population, 7% are children (34 million) who, along with their families, grapple with the serious lifelong problems that accompany the disease. Methods: This descriptive cross-sectional study was conducted with facilities investigated consisting of a school for the deaf, hospitals, an audiology center, and a social agency in Hai Phong province from January 2013 to December 2014. A sample composed of 353 children was also recruited. Results: The examined facilities suffer from shortcomings in provision capacity, which manifest in deficient materials, supplies and equipment, and human resources; the lack of interdisciplinary coordination of activities; inadequate community awareness; and the unaddressed need for early detection and intervention. The conditions of most of the children (98%) were detected by their families, and among those who were clinically diagnosed, the majority (76.8%) received such diagnosis at central hospitals. Hearing impairment among the children were detected, diagnosed, and subjected to intervention at a very late stage (on average, at ages 22.3, 34, and 32.5 months, respectively), thereby compelling up to 63.6% of the families to struggle with their children’s hearing loss. Conclusion: Solutions to current interventions are needed to enhance service delivery systems and guarantee early detection as well as timely and appropriate treatment

A numerical model for water-oil flow in naturally fractured reservoirs

This paper describes the development of a three-dimensional, two-phase model for simulating the flow of water and oil in naturally fractured reservoirs. The model is based on the dual porosity approach. Main flow in the reservoir occurs within the fractures with local exchange of fluids between the fracture system and matrix blocks. A new formula for matrix/fracture fluid exchange rate is proposed based on an extension of the equation developed by Kazemi to account the gravity effects. This formula allows to eliminate the matrix pressure in the pressure equation for fractures and makes the solution algorithm easier.Some example calculations are presented to validate the model. These include a comparison of the results of this paper with previous results, showing the gravity effects and applicability of the model for field-scale problems

An algorithm for simultaneous determination of pressure and temperature distribution in oil-producing tube flow and the counter flow in gas-lift annulus

An algorithm for simultaneous determination of pressure and temperature distribution in oil-producing tube flow and the counter flow in gas-lift annulus has been proposed. The algorithm is based on a double loop iterative procedure and shooting method. The two-phase flow calculation for pressure Used in the algorithm is based on improved methods of Beggs and Brills, Orkissewski or Hagedorn and Brown. The numerical implementation for an example is presented to assure the applicability of proposed algorithm

Oseltamivir resistance during treatment of influenza A (H5N1) infection

Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents. Copyright © 2005 Massachusetts Medical Society.published_or_final_versio

Uplink Sum Throughput Analysis and Maximization for Integrated Satellite-Terrestrial Cell-Free Massive MIMO

peer reviewedThis paper studies multiple-access scenarios where users are cooperatively served by the satellite and terrestrial access points (APs). We derive the uplink ergodic throughput of scheduled users under practical conditions where maximumradio combining is exploited locally at the ground gateway and the APs. The analytical result explicitly unveils the effects of pilot contamination and channel conditions on the achievable throughput of each scheduled user in the uplink data transmission. The system can explicitly define the scheduled users and perform the power allocation by maximizing the sum throughput using either model-based or learning-based approaches. Numerical results demonstrate that the cooperation between space and ground systems brings superior throughput improvements over either space or ground networks. Even though most users can be simultaneously served, some may not be scheduled in each coherence interval due to limited radio resources

Indoor PM₀.₁ and PM₂.₅ in Hanoi: Chemical characterization, source identification, and health risk assessment

This study attempted to provide comprehensive insights into the chemical composition, source identification, and health risk assessment of indoor particulate matter (PM) in urban areas of Vietnam. Three hundred and twenty daily samples of PM₀.₁ and PM₂.₅ were collected at three different types of dwellings in Hanoi in two seasons, namely summer and winter. The samples were analyzed for 10 trace elements (TEs), namely Cr, Mn, Co, Cu, Ni, Zn, As, Cd, Sn, and Pb. The daily average concentrations of indoor PM₀.₁ and PM₂.₅ in the city were in the ranges of 7.0–8.9 μg/m³ and 43.3–106 μg/m³, respectively. The average concentrations of TEs bound to indoor PM ranged from 66.2 ng/m³ to 216 ng/m³ for PM₀.₁ and 391 ng/m³ to 2360 ng/m³ for PM₂.₅. Principle component analysis and enrichment factor were applied to identify the possible sources of indoor PM. Results showed that indoor PM₂.₅ was mainly derived from outdoor sources, whereas indoor PM₀.₁ was derived from indoor and outdoor sources. Domestic coal burning, industrial and traffic emissions were observed as outdoor sources, whereas household dust and indoor combustion were found as indoor sources. 80% of PM₂.₅ was deposited in the head airways, whereas 75% of PM₀.₁ was deposited in alveolar region. Monte Carlo simulation indicated that the intake of TEs in PM₂.₅ can lead to high carcinogenic risk for people over 60 years old and unacceptable non-carcinogenic risks for all ages at the roadside house in winter

RESEARCH AND DEVELOPMENT OF GENETIC ENGINEERING IN MEDICINE AND AGRICULTURE IN THE UNITED STATES OF AMERICA

The status of research, development and application of genetic technology in the US has been reflected through efforts and accomplishments in numerous fields including research, medicine, industrial biotechnology and agriculture in the past decades. In the area of medicine, the field of therapeutic purposes on human is the pioneer, in which gene therapy is attempted to carry out in various clinical trials. Diagnostic applications of human diseases which focus primarily on infectious diseases, cancer, pharmacogenomics and screening for inherited diseases by using molecular techniques related to PCR, next generation sequencing are followed. In addition, preparatory studies on human cells utilizing CRISPR/Cas9 genome editing technology have been undertaken in hopes of finding new treatments for cancer and rare form of eye disorder. In the field of agriculture, many large companies in the US have been developing varieties of genetically modified crops with traits of herbicide tolerance, insect resistance, drought resistance and nutrition enhancement. Among the biotech crops, proportion of planted acres of genetically engineered soybean, corn and cotton were increased rapidly and forecasted to expand in the coming years. Studies on generating genetically modified animals and fisheries have also been concentrated in order to not only resist diseases, enhance nutrition, but also provide pharmaceutical compounds. Application of new gene editing techniques such as CRISPR/Cas9 on plants and animals help biotech products have more opportunities to be approved for commercial sale in the US market. In general, although the research and application of genetic engineering in the US has outstripped worldwide, numerous obstacles are still encountered due to serious ethical regulations and controversy regarding to human health and environment. The US government continues to establish suitable policies and invest in science and technology to improve the quality of human life