6 research outputs found
Strategic factors on interpreting remanufacturing quality- Certifying framework to address warranty aftermarket for Malaysian industry
While the concept of remanufacturing is gaining popularity globally, literature and
theory on strategic decision-making on certifying for warranty in this area remain limited. A
strategic and establish concept flow is developed based on extensive literature review and
surveys with experienced experts who are dealing with remanufactured, reconditioned, rebuilt
and reused components. The remanufacturing research on evaluating quality assurance of
remanufactured component targets macro-level parameters and the indicators which must be
confirmed for evaluation. The strategic remanufacturing factors identified from the literature
review are discussed in a brainstorming session with a number of remanufacturing researchers
and academic experts. The study is further broadened by industrial surveys and case studies to
justify the inputs on developing a framework to certify remanufactured components.
Preliminary results have established the key factors of remanufacturing quality control that
might lead to the strict quality assurance of remanufactured components. Later, the developed
framework can be used as a benchmarking tool to certify remanufactured components and
warranty issuance. The findings serve as the foundation for further research concerning
Original Equipment Manufacturer (OEM) or Original Equipment Remanufacturer (OER) and
Independent Equipment Remanufacturer (IER) in the Malaysian Remanufacturing Industry
Targeted gene sanger sequencing should remain the first-tier genetic test for children suspected to have the five common X-linked inborn errors of immunity
DATA AVAILABILITY STATEMENT : The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding author.To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited
regions, our centre developed and offered free genetic testing for the most common IEI by
Sanger sequencing (SS) since 2001. With the establishment of The Asian Primary
Immunodeficiency (APID) Network in 2009, the awareness and definitive diagnosis of
IEI were further improved with collaboration among centres caring for IEI patients from
East and Southeast Asia. We also started to use whole exome sequencing (WES) for
undiagnosed cases and further extended our collaboration with centres from South Asia
and Africa. With the increased use of Next Generation Sequencing (NGS), we have shifted
our diagnostic practice from SS to WES. However, SS was still one of the key diagnostic
tools for IEI for the past two decades. Our centre has performed 2,024 IEI SS genetic
tests, with in-house protocol designed specifically for 84 genes, in 1,376 patients with 744
identified to have disease-causing mutations (54.1%). The high diagnostic rate after just
one round of targeted gene SS for each of the 5 common IEI (X-linked
agammaglobulinemia (XLA) 77.4%, Wiskott–Aldrich syndrome (WAS) 69.2%, X-linked chronic granulomatous disease (XCGD) 59.5%, X-linked severe combined
immunodeficiency (XSCID) 51.1%, and X-linked hyper-IgM syndrome (HIGM1) 58.1%)
demonstrated targeted gene SS should remain the first-tier genetic test for the 5 common
X-linked IEI.The Hong Kong Society for Relief of Disabled Children and Jeffrey Modell Foundation.http://www.frontiersin.org/Immunologyam2023Paediatrics and Child Healt