Synthesis and super-resolution imaging performance of a refractive-index-controllable microsphere superlens

Microspheres can function as optical superlenses for nanoscale super-resolution imaging. The imaging performance is mainly affected by the size and refractive index of the microsphere. Precise control of these parameters is a challenging task but of fundamental importance to the further development of the technique. In this study, we demonstrate for the first time a nanoparticle-hybrid suspension polymerization approach to chemically synthesize high-quality microspheres (ZrO2/polystyrene) with optical properties that are highly controllable. Microspheres of different sizes (d: 2�20 μm) and refractive indexes (np: 1.590�1.685) were synthesized and their super-resolution imaging performances were evaluated and compared. Our results show that continuously increasing the refractive index of microspheres can enhance the imaging resolution and quality. A 60 nm resolution has been obtained in the wide-field imaging mode and a 50 nm resolution has been obtained in the confocal mode imaging of semiconductor chip samples. The obtained 50�60 nm resolutions have significantly gone beyond the conventional 200 nm resolution limit for visible light optical microscopes; the super-resolution mechanism has been discussed. The synthesized microsphere superlenses may find applications in many other areas as well, including nanolithography, nano-sensing, nano-diagnosis, nano-spectroscopy and ultra-high density optical data storage

The role of Sox6 in zebrafish muscle fiber type specification

Background The transcription factor Sox6 has been implicated in regulating muscle fiber type-specific gene expression in mammals. In zebrafish, loss of function of the transcription factor Prdm1a results in a slow to fast-twitch fiber type transformation presaged by ectopic expression of sox6 in slow-twitch progenitors. Morpholino-mediated Sox6 knockdown can suppress this transformation but causes ectopic expression of only one of three slow-twitch specific genes assayed. Here, we use gain and loss of function analysis to analyse further the role of Sox6 in zebrafish muscle fiber type specification. Methods The GAL4 binary misexpression system was used to express Sox6 ectopically in zebrafish embryos. Cis-regulatory elements were characterized using transgenic fish. Zinc finger nuclease mediated targeted mutagenesis was used to analyse the effects of loss of Sox6 function in embryonic, larval and adult zebrafish. Zebrafish transgenic for the GCaMP3 Calcium reporter were used to assay Ca2+ transients in wild-type and mutant muscle fibres. Results Ectopic Sox6 expression is sufficient to downregulate slow-twitch specific gene expression in zebrafish embryos. Cis-regulatory elements upstream of the slow myosin heavy chain 1 (smyhc1) and slow troponin c (tnnc1b) genes contain putative Sox6 binding sites required for repression of the former but not the latter. Embryos homozygous for sox6 null alleles expressed tnnc1b throughout the fast-twitch muscle whereas other slow-specific muscle genes, including smyhc1, were expressed ectopically in only a subset of fast-twitch fibers. Ca2+ transients in sox6 mutant fast-twitch fibers were intermediate in their speed and amplitude between those of wild-type slow- and fast-twitch fibers. sox6 homozygotes survived to adulthood and exhibited continued misexpression of tnnc1b as well as smaller slow-twitch fibers. They also exhibited a striking curvature of the spine. Conclusions The Sox6 transcription factor is a key regulator of fast-twitch muscle fiber differentiation in the zebrafish, a role similar to that ascribed to its murine ortholog

Virtual Effects of Split SUSY in Higgs Productions at Linear Colliders

In split supersymmetry the gauginos and higgsinos are the only supersymmetric particles possibly accessible at foreseeable colliders like the CERN Large Hadron Collider (LHC) and the International Linear Collider (ILC). In order to account for the cosmic dark matter measured by WMAP, these gauginos and higgsinos are stringently constrained and could be explored at the colliders through their direct productions and/or virtual effects in some processes. The clean environment and high luminosity of the ILC render the virtual effects of percent level meaningful in unraveling the new physics effects. In this work we assume split supersymmetry and calculate the virtual effects of the WMAP-allowed gauginos and higgsinos in Higgs productions e+e- -> Z h and e+e- -> \nu_e \bar_\nu_e h through WW fusion at the ILC. We find that the production cross section of e+e- -> Zh can be altered by a few percent in some part of the WMAP-allowed parameter space, while the correction to the WW-fusion process e+e- -> \nu_e \bar_\nu_e h is below 1%. Such virtual effects are correlated with the cross sections of chargino pair productions and can offer complementary information in probing split supersymmetry at the colliders.Comment: more discussions added (7 pages, 10 figs

Missing Transverse-Doppler Effect in Time-Dilation Experiments with High-Speed Ions

Recent experiments with high-speed ions have investigated potential deviations from the time-dilation predicted by special relativity (SR). The main contribution of this article is to show that the SR predictions are matched by the experimental results only when the transverse Doppler effect in the observed emissions from the ions are neglected in the analysis. However, the Doppler effect in the emission cannot be neglected because it is similar to the time dilation effect. Thus, the article highlights the need to consider Doppler emission effects when validating SR time dilation using high-speed ion experiments.Comment: 3 pages, 3 figure

Possible large phase in psi(2S) -> 1-0- Decays

The strong and the electromagnetic amplitudes are analyzed on the basis of the measurements of J/psi, psi(2S) -> 1-0- in e+e- experiments. The currently available experimental information is revised with inclusion of the contribution from e+e- -> gamma * -> 1-0- . The study shows that a large phase around minus 90 degree between the strong and the electromagnetic amplitudes could not be ruled out by the experimental data for psi(2S).Comment: 4 page

Radiative Neutralino Decay in Split Supersymmetry

Radiative neutralino decay $\chi^0_2 -> \chi^0_1\gamma$ is studied in a Split Supersymmetric scenario, and compared with mSUGRA and MSSM. This 1-loop process has a transition amplitude which is often quite small, but has the advantage of providing a very clear and distinct signature: electromagnetic radiation plus missing energy. In Split Supersymmetry this radiative decay is in direct competition with the tree-level three-body decay $\chi^0_2 -> \chi^0_1 f\overline f$, and we obtain large values for the branching ratio $B(\chi^0_2 -> \chi^0_1\gamma)$ which can be close to unity in the region $M_2 \sim M_1$. Furthermore, the value for the radiative neutralino decay branching ratio has a strong dependence on the split supersymmetric scale $\widetilde{m}$, which is otherwise very difficult to infer from experimental observables.Comment: 15 pages and 10 figure

Emerging Viruses: Coming in on a Wrinkled Wing and a Prayer

The role that bats have played in the emergence of several new infectious diseases has been under review. Bats have been identified as the reservoir hosts of newly emergent viruses such as Nipah virus, Hendra virus, and severe acute respiratory syndrome–like coronaviruses. This article expands on recent findings about bats and viruses and their relevance to human infections. It briefly reviews the history of chiropteran viruses and discusses their emergence in the context of geography, phylogeny, and ecology. The public health and trade impacts of several outbreaks are also discussed. Finally, we attempt to predict where, when, and why we may see the emergence of new chiropteran viruses

Analysing Lyapunov spectra of chaotic dynamical systems

It is shown that the asymptotic spectra of finite-time Lyapunov exponents of a variety of fully chaotic dynamical systems can be understood in terms of a statistical analysis. Using random matrix theory we derive numerical and in particular analytical results which provide insights into the overall behaviour of the Lyapunov exponents particularly for strange attractors. The corresponding distributions for the unstable periodic orbits are investigated for comparison.Comment: 4 pages, 4 figure

A self-consistent treatment of non-equilibrium spin torques in magnetic multilayers

It is known that the transfer of spin angular momenta between current carriers and local moments occurs near the interface of magnetic layers when their moments are non-collinear. However, to determine the magnitude of the transfer, one should calculate the spin transport properties far beyond the interface regions. Based on the spin diffusion equation, we present a self-consistent approach to evaluate the spin torque for a number of layered structures. One of the salient features is that the longitudinal and transverse components of spin accumulations are inter-twined from one layer to the next, and thus, the spin torque could be significantly amplified with respect to treatments which concentrate solely on the transport at the interface due to the presence of the much longer longitudinal spin diffusion length. We conclude that bare spin currents do not properly estimate the spin angular momentum transferred between to the magnetic background; the spin transfer that occurs at interfaces should be self-consistently determined by embedding it in our globally diffuse transport calculations.Comment: 21 pages, 6 figure

Force-based Cooperative Search Directions in Evolutionary Multi-objective Optimization

International audienceIn order to approximate the set of Pareto optimal solutions, several evolutionary multi-objective optimization (EMO) algorithms transfer the multi-objective problem into several independent single-objective ones by means of scalarizing functions. The choice of the scalarizing functions' underlying search directions, however, is typically problem-dependent and therefore difficult if no information about the problem characteristics are known before the search process. The goal of this paper is to present new ideas of how these search directions can be computed \emph{adaptively} during the search process in a \emph{cooperative} manner. Based on the idea of Newton's law of universal gravitation, solutions attract and repel each other \emph{in the objective space}. Several force-based EMO algorithms are proposed and compared experimentally on general bi-objective $\rho$MNK landscapes with different objective correlations. It turns out that the new approach is easy to implement, fast, and competitive with respect to a $(\mu+\lambda)$-SMS-EMOA variant, in particular if the objectives show strong positive or negative correlations