Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of Nuclear factor (erythroid-derived 2)-like 2

Perinatal hypoxic ischaemic encephalopathy (HIE) has a high mortality rate with neuropsychological impairment. This study investigated the neuroprotective effects of argon against neonatal hypoxic-ischaemic brain injury. In vitro cortical neuronal cell cultures derived from rat foetuses were subjected to an oxygen and glucose deprivation (OGD) challenge for 90 minutes and then exposed to 70% argon or nitrogen with 5% carbon dioxide and balanced with oxygen for 2 hours. In vivo, seven-day-old rats were subjected to unilateral common carotid artery ligation followed by hypoxic (8% oxygen balanced with nitrogen) insult for 90 minutes. They were exposed to 70% argon or nitrogen balanced with oxygen for 2 hours. In vitro, argon treatment of cortical neuronal cultures resulted in a significant increase of p-mTOR and Nuclear factor (erythroid-derived 2)-like 2(Nrf2) and protection against OGD challenge. Inhibition of m-TOR through Rapamycin or Nrf2 through siRNA abolished argon-mediated cyto-protection. In vivo, argon exposure significantly enhanced Nrf2 and its down-stream effector NAD(P)H Dehydrogenase, Quinone 1(NQO1) and superoxide dismutase 1(SOD1). Oxidative stress, neuroinflammation and neuronal cell death were significantly decreased and brain infarction was markedly reduced. Blocking PI-3K through wortmannin or ERK1/2 through U0126 attenuated argon-mediated neuroprotection. These data provide a new molecular mechanism for the potential application of Argon as a neuroprotectant in HIE

Low Redshift Intergalactic Absorption Lines in the Spectrum of HE0226-4110

We present an analysis of the FUSE and STIS E140M spectra of HE0226-4110 (z=0.495). We detect 56 Lyman absorbers and 5 O VI absorbers. The number of intervening O VI systems per unit redshift with W>50 m\AA is dN(O VI)/dz~ 11. The O VI systems unambiguously trace hot gas only in one case. For the 4 other O VI systems, photoionization and collisional ionization models are viable options to explain the observed column densities of the O VI and the other ions. If the O VI systems are mostly photoionized, only a fraction of the observed O VI will contribute to the baryonic density of the warm-hot ionized medium (WHIM) along this line of sight. Combining our results with previous ones, we show that there is a general increase of N(O VI) with increasing b(O VI). Cooling flow models can reproduce the N-b distribution but fail to reproduce the observed ionic ratios. A comparison of the number of O I, O II, O III, O IV, and O VI systems per unit redshift show that the low-z IGM is more highly ionized than weakly ionized. We confirm that photoionized O VI systems show a decreasing ionization parameter with increasing H I column density. O VI absorbers with collisional ionization/photoionization degeneracy follow this relation, possibly suggesting that they are principally photoionized. We find that the photoionized O VI systems in the low redshift IGM have a median abundance of 0.3 solar. We do not find additional Ne VIII systems other than the one found by Savage et al., although our sensitivity should have allowed the detection of Ne VIII in O VI systems at T~(0.6-1.3)x10^6 K (if CIE applies). Since the bulk of the WHIM is believed to be at temperatures T>10^6 K, the hot part of the WHIM remains to be discovered with FUV--EUV metal-line transitions.Comment: Accepted for publication in the ApJS. Full resolution figures available at http://www.journals.uchicago.edu/ApJ/journal/preprints/ApJS63975.preprint.pd

Two scenarios for avalanche dynamics in inclined granular layers

We report experimental measurements of avalanche behavior of thin granular layers on an inclined plane for low volume flow rate. The dynamical properties of avalanches were quantitatively and qualitatively different for smooth glass beads compared to irregular granular materials such as sand. Two scenarios for granular avalanches on an incline are identified and a theoretical explanation for these different scenarios is developed based on a depth-averaged approach that takes into account the differing rheologies of the granular materials.Comment: 4 pages, 4 figures, accepted to Phys. Rev. Let

Multi-wavelength analysis of 18um-selected galaxies in the AKARI/IRC monitor field towards the North Ecliptic Pole

We present an initial analysis of AKARI 18um-selected galaxies using all 9 photometric bands at 2-24um available in the InfraRed Camera (IRC), in order to demonstrate new capabilities of AKARI cosmological surveys. We detected 72 sources at 18um in an area of 50.2 arcmin^2 in the AKARI/IRC monitor field towards the North Ecliptic Pole (NEP). From this sample, 25 galaxies with probable redshifts z>~ 0.5 are selected with a single colour cut (N2-N3>0.1) for a detailed SED analysis with ground-based BVRi'z'JK data. Using an SED radiative transfer model of starbursts covering the wavelength range UV -- submm, we derive photometric redshifts from the optical-MIR SEDs of 18um-selected galaxies. From the best-fit SED models, we show that the IRC all-band photometry is capable of tracing the steep rise in flux at the blue side of the PAH 6.2um emission feature. This indicates that the IRC all-band photometry is useful to constrain the redshift of infrared galaxies, specifically for dusty galaxies with a less prominent 4000A break. Also, we find that the flux dip between the PAH 7.7 and 11.2um emission feature is recognizable in the observed SEDs of galaxies at z~1. By using such a colour anomaly due to the PAH and silicate absorption features, unique samples of ULIRGs at z~1, `silicate-break' galaxies, can be constructed from large cosmological surveys of AKARI towards the NEP, i.e. the NEP-Deep and NEP-Wide survey. This pilot study suggests the possibility of detecting many interesting galaxy properties in the NEP-Deep and Wide surveys, such as a systematic difference in SEDs between high- and low-z ULIRGs, and a large variation of the PAH inter-band strength ratio in galaxies at high redshifts. [abridged]Comment: Accepted for publication in PASJ, AKARI special issu

Intermittency transitions to strange nonchaotic attractors in a quasiperiodically driven Duffing oscillator

Different mechanisms for the creation of strange nonchaotic attractors (SNAs) are studied in a two-frequency parametrically driven Duffing oscillator. We focus on intermittency transitions in particular, and show that SNAs in this system are created through quasiperiodic saddle-node bifurcations (Type-I intermittency) as well as through a quasiperiodic subharmonic bifurcation (Type-III intermittency). The intermittent attractors are characterized via a number of Lyapunov measures including the behavior of the largest nontrivial Lyapunov exponent and its variance as well as through distributions of finite-time Lyapunov exponents. These attractors are ubiquitous in quasiperiodically driven systems; the regions of occurrence of various SNAs are identified in a phase diagram of the Duffing system.Comment: 24 pages, RevTeX 4, 12 EPS figure

The properties of highly luminous IRAS galaxies

From a complete sample of 154 galaxies identified with IRAS sources in a 304 sq deg area centered on the South Galactic Pole, a subsample of 58 galaxies with L sub IR/L sub B > 3 was chosen. Low resolution spectra were obtained for 30% of the subsample and redshifts and relative emission line intensities were derived. As a class these galaxies are very luminous with = 2.9 x 10 to the 11th power L sub 0 and (L sub IR) max = 1.3 x 10 to the 12th power L sub 0. CCD images and JHK photometry were obtained for many of the subsample. The galaxies are for the most part newly identified and are optically faint, with a majority showing evidence of a recent interaction. Radio continuum observations of all galaxies of the subsample were recently obtained at 20 cm VLA with about 75% being detected in a typical integration time of about 10 minutes

Subdiffusive axial transport of granular materials in a long drum mixer

Granular mixtures rapidly segregate radially by size when tumbled in a partially filled horizontal drum. The smaller component moves toward the axis of rotation and forms a buried core, which then splits into axial bands. Models have generally assumed that the axial segregation is opposed by diffusion. Using narrow pulses of the smaller component as initial conditions, we have characterized axial transport in the core. We find that the axial advance of the segregated core is well described by a self-similar concentration profile whose width scales as $t^\alpha$, with $\alpha \sim 0.3 < 1/2$. Thus, the process is subdiffusive rather than diffusive as previously assumed. We find that $\alpha$ is nearly independent of the grain type and drum rotation rate within the smoothly streaming regime. We compare our results to two one-dimensional PDE models which contain self-similarity and subdiffusion; a linear fractional diffusion model and the nonlinear porous medium equation.Comment: 4 pages, 4 figures, 1 table. Submitted to Phys Rev Lett. For more info, see http://www.physics.utoronto.ca/nonlinear

The Emergence of the Modern Universe: Tracing the Cosmic Web

This is the report of the Ultraviolet-Optical Working Group (UVOWG) commissioned by NASA to study the scientific rationale for new missions in ultraviolet/optical space astronomy approximately ten years from now, when the Hubble Space Telescope (HST) is de-orbited. The UVOWG focused on a scientific theme, The Emergence of the Modern Universe, the period from redshifts z = 3 to 0, occupying over 80% of cosmic time and beginning after the first galaxies, quasars, and stars emerged into their present form. We considered high-throughput UV spectroscopy (10-50x throughput of HST/COS) and wide-field optical imaging (at least 10 arcmin square). The exciting science to be addressed in the post-HST era includes studies of dark matter and baryons, the origin and evolution of the elements, and the major construction phase of galaxies and quasars. Key unanswered questions include: Where is the rest of the unseen universe? What is the interplay of the dark and luminous universe? How did the IGM collapse to form the galaxies and clusters? When were galaxies, clusters, and stellar populations assembled into their current form? What is the history of star formation and chemical evolution? Are massive black holes a natural part of most galaxies? A large-aperture UV/O telescope in space (ST-2010) will provide a major facility in the 21st century for solving these scientific problems. The UVOWG recommends that the first mission be a 4m aperture, SIRTF-class mission that focuses on UV spectroscopy and wide-field imaging. In the coming decade, NASA should investigate the feasibility of an 8m telescope, by 2010, with deployable optics similar to NGST. No high-throughput UV/Optical mission will be possible without significant NASA investments in technology, including UV detectors, gratings, mirrors, and imagers.Comment: Report of UV/O Working Group to NASA, 72 pages, 13 figures, Full document with postscript figures available at http://casa.colorado.edu/~uvconf/UVOWG.htm

Excitation spectrum and instability of a two-species Bose-Einstein condensate

We numerically calculate the density profile and excitation spectrum of a two-species Bose-Einstein condensate for the parameters of recent experiments. We find that the ground state density profile of this system becomes unstable in certain parameter regimes, which leads to a phase transition to a new stable state. This state displays spontaneously broken cylindrical symmetry. This behavior is reflected in the excitation spectrum: as we approach the phase transition point, the lowest excitation frequency goes to zero, indicating the onset of instability in the density profile. Following the phase transition, this frequency rises again.Comment: 8 pages, 5 figures, uses REVTe

Continuous Avalanche Segregation of Granular Mixtures in Thin Rotating Drums

We study segregation of granular mixtures in the continuous avalanche regime (for frequencies above ~ 1 rpm) in thin rotating drums using a continuum theory for surface flows of grains. The theory predicts profiles in agreement with experiments only when we consider a flux dependent velocity of flowing grains. We find the segregation of species of different size and surface properties, with the smallest and roughest grains being found preferentially at the center of the drum. For a wide difference between the species we find a complete segregation in agreement with experiments. In addition, we predict a transition to a smooth segregation regime - with an power-law decay of the concentrations as a function of radial coordinate - as the size ratio between the grains is decreased towards one.Comment: 4 pages, 4 figures, http://polymer.bu.edu/~hmaks