Waste Corn as a Source of Inoculum of Aspergillus Flavus, the Cause of Aflatoxin

Aspergillus Flavus occurs worldwide in diverse habitats on a variety of plant and animal substrates. In the United States, contamination of susceptible crops particularly maize, peanuts, cottonseed, and tree nuts has become a major health concern because of the development of the carcinogen, aflatoxin. Extensive research into all aspects of the biology of A. flavus over the past twenty years still has left many unanswered but very basic questions about the ecology of this important organism

Splitting of a doubly quantized vortex through intertwining in Bose-Einstein condensates

The stability of doubly quantized vortices in dilute Bose-Einstein condensates of 23Na is examined at zero temperature. The eigenmode spectrum of the Bogoliubov equations for a harmonically trapped cigar-shaped condensate is computed and it is found that the doubly quantized vortex is spectrally unstable towards dissection into two singly quantized vortices. By numerically solving the full three-dimensional time-dependent Gross-Pitaevskii equation, it is found that the two singly quantized vortices intertwine before decaying. This work provides an interpretation of recent experiments [A. E. Leanhardt et al. Phys. Rev. Lett. 89, 190403 (2002)].Comment: 4 pages, 3 figures (to be published in PRA

Ultraviolet Imaging Polarimetry of the Large Magellanic Cloud. II. Models

Motivated by new sounding-rocket wide-field polarimetric images of the Large Magellanic Cloud, we have used a three-dimensional Monte Carlo radiation transfer code to investigate the escape of near-ultraviolet photons from young stellar associations embedded within a disk of dusty material (i.e. a galaxy). As photons propagate through the disk, they may be scattered or absorbed by dust. Scattered photons are polarized and tracked until they escape to be observed; absorbed photons heat the dust, which radiates isotropically in the far-infrared, where the galaxy is optically thin. The code produces four output images: near- UV and far-IR flux, and near-UV images in the linear Stokes parameters Q and U. From these images we construct simulated UV polarization maps of the LMC. We use these maps to place constraints on the star + dust geometry of the LMC and the optical properties of its dust grains. By tuning the model input parameters to produce maps that match the observed polarization maps, we derive information about the inclination of the LMC disk to the plane of the sky, and about the scattering phase function g. We compute a grid of models with i = 28 deg., 36 deg., and 45 deg., and g = 0.64, 0.70, 0.77, 0.83, and 0.90. The model which best reproduces the observed polarization maps has i = 36 +2/-5 degrees and g ~0.7. Because of the low signal-to-noise in the data, we cannot place firm constraints on the value of g. The highly inclined models do not match the observed centro-symmetric polarization patterns around bright OB associations, or the distribution of polarization values. Our models approximately reproduce the observed ultraviolet photopolarimetry of the western side of the LMC; however, the output images depend on many input parameters and are nonunique.Comment: Accepted to AJ. 20 pages, 7 figure

Coping Strategies of Family Members of Hospitalized Psychiatric Patients

This exploratory research paper investigated the coping strategies of families of hospitalized psychiatric patients and identified their positive and negative coping strategies. In this paper, the coping strategies of 45 family members were examined using a descriptive, correlational, mixed method research approach. Guided by the Neuman Systems Model and using the Family Crisis Oriented Personal Evaluation Scales and semistructured interviews, this paper found that these family members used more emotion-focused coping strategies than problem-focused coping strategies. The common coping strategies used by family members were communicating with immediate family, acceptance of their situation, passive appraisal, avoidance, and spirituality. The family members also utilized resources and support systems, such as their immediate families, mental health care professionals, and their churches

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form. It is responsible for proteolytic cleavage of many peptide substrates. In this review we discuss the idea that DPP4-cleaved peptides are not necessarily inactivated, but rather can possess either a modified receptor selectivity, modified bioactivity, new antagonistic activity, or even a novel activity relative to the intact parent ligand. We examine in detail five different major DPP4 substrates: glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), peptide tyrosine-tyrosine (PYY), and neuropeptide Y (NPY), and stromal derived factor 1 (SDF-1 aka CXCL12). We note that discussion of the cleaved forms of these five peptides are underrepresented in the research literature, and are both poorly investigated and poorly understood, representing a serious research literature gap. We believe they are understudied and misinterpreted as inactive due to several factors. This includes lack of accurate and specific quantification methods, sample collection techniques that are inherently inaccurate and inappropriate, and a general perception that DPP4 cleavage inactivates its ligand substrates. Increasing evidence points towards many DPP4-cleaved ligands having their own bioactivity. For example, GLP-1 can work through a different receptor than GLP-1R, DPP4-cleaved GIP can function as a GIP receptor antagonist at high doses, and DPP4-cleaved PYY, NPY, and CXCL12 can have different receptor selectivity, or can bind novel, previously unrecognized receptors to their intact ligands, resulting in altered signaling and functionality. We believe that more rigorous research in this area could lead to a better understanding of DPP4’s role and the biological importance of the generation of novel cryptic ligands. This will also significantly impact our understanding of the clinical effects and side effects of DPP4-inhibitors as a class of anti-diabetic drugs that potentially have an expanding clinical relevance. This will be specifically relevant in targeting DPP4 substrate ligands involved in a variety of other major clinical acute and chronic injury/disease areas including inflammation, immunology, cardiology, stroke, musculoskeletal disease and injury, as well as cancer biology and tissue maintenance in aging

Rotational Dynamics of Vortices in Confined Bose-Einstein Condensates

We derive the frequency of precession and conditions for stability for a quantized vortex in a single-component and a two-component Bose-Einstein condensate. The frequency of precession is proportional to the gradient of the free energy with respect to displacement of the vortex core. In a two-component system, it is possible to achieve a local minimum in the free energy at the center of the trap. The presence of such a minimum implies the existence of a region of energetic stability where the vortex cannot escape and where one may be able to generate a persistent current.Comment: 6 Pages, 6 Figure

Magellanic Cloud Structure from Near-IR Surveys II: Star Count Maps and the Intrinsic Elongation of the LMC

I construct a near-IR star count map of the LMC and demonstrate, using the viewing angles derived in Paper I, that the LMC is intrinsically elongated. I argue that this is due to the tidal force from the Milky Way. The near-IR data from the 2MASS and DENIS surveys are used to create a star count map of RGB and AGB stars, which is interpreted through ellipse fitting. The radial number density profile is approximately exponential with a scale-length 1.3-1.5 kpc. However, there is an excess density at large radii that may be due to the tidal effect of the Milky Way. The position angle and ellipticity profile converge to PA_maj = 189.3 +/- 1.4 degrees and epsilon = 0.199 +/- 0.008 for r > 5 deg. At large radii there is a drift of the center of the star count contours towards the near side of the plane, which can be undrestood as due to viewing perspective. The fact that PA_maj differes from the line of nodes position angle Theta = 122.5 +/- 8.3 (cf. Paper I) indicates that the LMC disk is not circular, but has an intrinsic ellipticity of 0.31. The LMC is elongated in the general direction of the Galactic center, and is elongated perpendicular to the Magellanic Stream and the velocity vector of the LMC center of mass. This suggests that the elongation of the LMC has been induced by the tidal force of the Milky Way. The position angle of the line of nodes differs from the position angle Theta_max of the line of maximum line of sight velocity gradient: Theta_max - Theta = 20-60 degrees. This could be due to: (a) streaming along non-circular orbits in the elongated disk; (b) uncertainties in the transverse motion of the LMC center of mass; (c) precession and nutation of the LMC disk as it orbits the Milky Way (expected on theoretical grounds). [Abridged]Comment: Astronomical Journal, in press. 34 pages, LaTeX, with 7 PostScript figures. Contains minor revisions with respect to previously posted version. Check out http://www.stsci.edu/~marel/lmc.html for a large scale (23x21 degree) stellar number-density image of the LMC constructed from RGB and AGB stars in the 2MASS and DENIS surveys. The paper is available with higher resolution color figures from http://www.stsci.edu/~marel/abstracts/abs_R32.htm