2,105 research outputs found
Andromeda's Parachute: A Bright Quadruply Lensed Quasar at z=2.377
We present Keck Cosmic Web Imager spectroscopy of the four putative images of
the lensed quasar candidate J014709+463037 recently discovered by Berghea et
al. (2017). The data verify the source as a quadruply lensed, broad
absorption-line quasar having z_S = 2.377 +/- 0.007. We detect intervening
absorption in the FeII 2586, 2600, MgII 2796, 2803, and/or CIV 1548, 1550
transitions in eight foreground systems, three of which have redshifts
consistent with the photometric-redshift estimate reported for the lensing
galaxy (z_L ~ 0.57). By virtue of their positions on the sky, the source images
probe these absorbers over transverse physical scales of ~0.3-21 kpc,
permitting assessment of the variation in metal-line equivalent width W_r as a
function of sight-line separation. We measure differences in W_r,2796 of <40%
across all sight-line pairs subtending 7-21 kpc, suggestive of a high degree of
spatial coherence for MgII-absorbing material. W_r,2600 is observed to vary by
>50% over the same scales across the majority of sight-line pairs, while CIV
absorption exhibits a wide range in W_r,1548 differences of ~5-80% within
transverse distances less than ~3 kpc. J014709+463037 is one of only a handful
of z > 2 quadruply lensed systems for which all four source images are very
bright (r = 15.4-17.7 mag) and are easily separated in ground-based seeing
conditions. As such, it is an ideal candidate for higher-resolution
spectroscopy probing the spatial variation in the kinematic structure and
physical state of intervening absorbers.Comment: Submitted to ApJL. 9 pages, 3 figures. Uses aastex61 forma
Poincar\'e gauge theory with even and odd parity dynamic connection modes: isotropic Bianchi cosmological models
The Poincar\'e gauge theory of gravity has a metric compatible connection
with independent dynamics that is reflected in the torsion and curvature. The
theory allows two good propagating spin-0 modes. Dynamical investigations using
a simple expanding cosmological model found that the oscillation of the 0
mode could account for an accelerating expansion similar to that presently
observed. The model has been extended to include a mode and more
recently cross parity couplings. We investigate the dynamics of this model in a
situation which is simple, non-trivial, and yet may give physically interesting
results that might be observable. We consider homogeneous cosmologies, more
specifically, isotropic Bianchi class A models. We find an effective Lagrangian
for our dynamical system, a system of first order equations, and present some
typical dynamical evolution.Comment: 8 pages, 1 figures, submitted to IARD 2010 Conference Proceedings in
{\em Journal of Physics: Conference Series}, eds. L. Horwitz and M. Land
(2011
Dilepton and Photon Emission Rates from a Hadronic Gas
We analyze the dilepton and photon emission rates from a hadronic gas using
chiral reduction formulas and a virial expansion. The emission rates are
reduced to pertinent vacuum correlation functions, most of which can be
assessed from experiment. Our results indicate that in the low mass region, the
dilepton and photon rates are enhanced compared to most of the calculations
using chiral Lagrangians. The enhancement is further increased through a finite
pion chemical potential. An estimate of the emission rates is also made using
Haag's expansion for the electromagnetic current. The relevance of these
results to dilepton and photon emission rates in heavy-ion collisions is
discussed.Comment: 7 pages, LaTeX using revTeX, 6 figures imbedded in text. Figures
slightly changed, text left unchange
Fermion Masses in Emergent Electroweak Symmetry Breaking
We consider the generation of fermion masses in an emergent model of
electroweak symmetry breaking with composite gauge bosons. A universal
bulk fermion profile in a warped extra dimension is used for all fermion
flavors. Electroweak symmetry is broken at the UV (or Planck) scale where
boundary mass terms are added to generate the fermion flavor structure. This
leads to flavor-dependent nonuniversality in the gauge couplings. The effects
are suppressed for the light fermion generations but are enhanced for the top
quark where the and couplings can deviate at the
level in the minimal setup. By the AdS/CFT correspondence our model
implies that electroweak symmetry is not a fundamental gauge symmetry. Instead
the Standard Model with massive fermions and gauge bosons is an effective
chiral Lagrangian for some underlying confining strong dynamics at the TeV
scale, where mass is generated without a Higgs mechanism.Comment: modified discussion in Sec 3.1, version published in JHE
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Influenza Virus in Human Exhaled Breath: An Observational Study
Background: Recent studies suggest that humans exhale fine particles during tidal breathing but little is known of their composition, particularly during infection. Methodology/Principal Findings: We conducted a study of influenza infected patients to characterize influenza virus and particle concentrations in their exhaled breath. Patients presenting with influenza-like-illness, confirmed influenza A or B virus by rapid test, and onset within 3 days were recruited at three clinics in Hong Kong, China. We collected exhaled breath from each subject onto Teflon filters and measured exhaled particle concentrations using an optical particle counter. Filters were analyzed for influenza A and B viruses by quantitative polymerase chain reaction (qPCR). Twelve out of thirteen rapid test positive patients provided exhaled breath filter samples (7 subjects infected with influenza B virus and 5 subjects infected with influenza A virus). We detected influenza virus RNA in the exhaled breath of 4 (33%) subjects–three (60%) of the five patients infected with influenza A virus and one (14%) of the seven infected with influenza B virus. Exhaled influenza virus RNA generation rates ranged from <3.2 to 20 influenza virus RNA particles per minute. Over 87% of particles exhaled were under 1 µm in diameter. Conclusions: These findings regarding influenza virus RNA suggest that influenza virus may be contained in fine particles generated during tidal breathing, and add to the body of literature suggesting that fine particle aerosols may play a role in influenza transmission
The variability and seasonality of the environmental reservoir of Mycobacterium bovis shed by wild European badgers
The incidence of Mycobacterium bovis, the causative agent of bovine tuberculosis, has been increasing in UK cattle herds resulting in substantial economic losses. The European badger (Meles meles) is implicated as a wildlife reservoir of infection. One likely route of transmission to cattle is through exposure to infected badger urine and faeces. The relative importance of the environment in transmission remains unknown, in part due to the lack of information on the distribution and magnitude of environmental reservoirs. Here we identify potential infection hotspots in the badger population and quantify the heterogeneity in bacterial load; with infected badgers shedding between 1 × 103 − 4 × 105 M. bovis cells g−1 of faeces, creating a substantial and seasonally variable environmental reservoir. Our findings highlight the potential importance of monitoring environmental reservoirs of M. bovis which may constitute a component of disease spread that is currently overlooked and yet may be responsible for a proportion of transmission amongst badgers and onwards to cattle
Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations
Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and fibril formation of amyloid-prone proteins. We employ classical molecular dynamics simulations and large-scale density functional theory calculations to investigate the effects of nanomaterials on the structure, dynamics and binding of an amyloidogenic peptide apoC-II(60-70). We show that the binding affinity of this peptide to carbonaceous nanomaterials such as C60, nanotubes and graphene decreases with increasing nanoparticle curvature. Strong binding is facilitated by the large contact area available for π-stacking between the aromatic residues of the peptide and the extended surfaces of graphene and the nanotube. The highly curved fullerene surface exhibits reduced efficiency for π-stacking but promotes increased peptide dynamics. We postulate that the increase in conformational dynamics of the amyloid peptide can be unfavorable for the formation of fibril competent structures. In contrast, extended fibril forming peptide conformations are promoted by the nanotube and graphene surfaces which can provide a template for fibril-growth
Photon Rates for Heavy-Ion Collisions from Hidden Local Symmetry
We study photon production from the hidden local symmetry approach that
includes pions, rho and a1 mesons and compute the corresponding photon emission
rates from a hadronic gas in thermal equilibrium. Together with experimental
radiative decay widths of the background, these rates are used in a
relativistic transport model to calculate single photon spectra in heavy-ion
collisions at SPS energies. We then employ this effective theory to test three
scenarios for the chiral phase transition in high-temperature nuclear matter
including decreasing vector meson masses. Although all calculations respect the
upper bound set by the WA80 Collaboration, we find the scenarios could be
distinguished with more detailed data.Comment: 12 pages, 12 Postscript figures; discussion of thermal equilibrium
rates expanded, minor corrections to text and graph
Mixed integer programming in production planning with backlogging and setup carryover : modeling and algorithms
This paper proposes a mixed integer programming formulation for modeling the capacitated multi-level lot sizing problem with both backlogging and setup carryover. Based on the model formulation, a progressive time-oriented decomposition heuristic framework is then proposed, where improvement and construction heuristics are effectively combined, therefore efficiently avoiding the weaknesses associated with the one-time decisions made by other classical time-oriented decomposition algorithms. Computational results show that the proposed optimization framework provides competitive solutions within a reasonable time
Microbial Co-Infection Alters Macrophage Polarization, Phagosomal Escape, and Microbial Killing
Macrophages are important innate immune cells that respond to microbial insults. In response to multi-bacterial infection, the macrophage activation state may change upon exposure to nascent mediators, which results in different bacterial killing mechanism(s). In this study, we utilized two respiratory bacterial pathogens, Mycobacterium bovis (Bacillus Calmette Guẻrin, BCG) and Francisella tularensis live vaccine strain (LVS) with different phagocyte evasion mechanisms, as model microbes to assess the influence of initial bacterial infection on the macrophage response to secondary infection. Non-activated (M0) macrophages or activated M2-polarized cells (J774 cells transfected with the mouse IL-4 gene) were first infected with BCG for 24–48 h, subsequently challenged with LVS, and the results of inhibition of LVS replication in the macrophages was assessed. BCG infection in M0 macrophages activated TLR2-MyD88 and Mincle-CARD9 signaling pathways, stimulating nitric oxide (NO) production and enhanced killing of LVS. BCG infection had little effect on LVS escape from phagosomes into the cytosol in M0 macrophages. In contrast, M2-polarized macrophages exhibited enhanced endosomal acidification, as well as inhibiting LVS replication. Pre-infection with BCG did not induce NO production and thus did not further reduce LVS replication. This study provides a model for studies of the complexity of macrophage activation in response to multi-bacterial infection
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