1,169 research outputs found
Understanding the Session Durability in Peer-to-Peer Storage System
This paper emphasizes that instead of long-term availability and reliability, the short-term session durability analysis will greatly impact the design of the real large-scale Peer-to-Peer storage system. In this paper, we use a Markov chain to model the session durability, and then derive the session durability probability distribution. Subsequently, we show the difference between our analysis and the traditional Mean Time to Failure (MTTF) analysis, from which we conclude that the misuse of MTTF analysis will greatly mislead our understanding of the session durability. We further show the impact of session durability analysis on the real system design. To our best knowledge, this is the first time ever to discuss the effects of session durability in large-scale Peer-to-Peer storage system.Computer Science, Theory & MethodsSCI(E)EICPCI-S(ISTP)
Tumor Uptake Study of 18F-labeled N-Acetylneuraminic Acids
開始ページ、終了ページ: 冊子体のページ付
Derivation of exact master equation with stochastic description: Dissipative harmonic oscillator
A systematic procedure for deriving the master equation of a dissipative
system is reported in the framework of stochastic description. For the
Caldeira-Leggett model of the harmonic-oscillator bath, a detailed and
elementary derivation of the bath-induced stochastic field is presented. The
dynamics of the system is thereby fully described by a stochastic differential
equation and the desired master equation would be acquired with statistical
averaging. It is shown that the existence of a closed-form master equation
depends on the specificity of the system as well as the feature of the
dissipation characterized by the spectral density function. For a dissipative
harmonic oscillator it is observed that the correlation between the stochastic
field due to the bath and the system can be decoupled and the master equation
naturally comes out. Such an equation possesses the Lindblad form in which time
dependent coefficients are determined by a set of integral equations. It is
proved that the obtained master equation is equivalent to the well-known
Hu-Paz-Zhang equation based on the path integral technique. The procedure is
also used to obtain the master equation of a dissipative harmonic oscillator in
time-dependent fields.Comment: 24page
Effect of Iodine Doping on BiSrCaCuO: Charge Transfer or Interlayer Coupling?
A comparative study has been made of iodine-intercalated
BiSrCaCuO single crystal and 1 atm O
annealed BiSrCaCuO single crystal using AC
susceptibility measurement, X-ray photoemission (XPS) and angle-resolved
ultraviolet photoemission spectroscopy (ARUPS). AC susceptibility measurement
indicates that O-doped samples studied have T of 84 K,
whereas T of Iodine-doped samples studied are 80 K. XPS Cu 2p core
level data establish that the hole concentration in the CuO planes are
essentially the same for these two kinds of samples. ARUPS measurements show
that electronic structure of the normal states near the Fermi level has been
strongly affected by iodine intercalation. We conclude that the dominant effect
of iodine doping is to alter the interlayer coupling.Comment: LBL 9 pages, APS_Revtex. 5 Figures, available upon request.
UW-Madison preprin
Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line
Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The β-actin promoter-driven KrasRz sequence (pHβ/KrasRz) was introduced into these cells (SW480/KrasRz), and we evaluated its effects on growth of the colon cancer. The gene expression of angiogenesis-related molecules (vascular endothelial growth factor and thrombospondin) was also estimated in SW480/KrasRz. KrasRz specifically and efficiently cleaved the mutant K-ras mRNA but not wild-type mRNA in vitro. SW480/KrasRz showed decreased growth rate under tissue culture conditions (P< 0.01, Dunnett’s test). The xenotransplantability of SW480/KrasRz (XeSW480/KrasRz) was significantly decreased in nude mice (P< 0.05, Fisher’s exact test). Tumour volume of the xenografts XeSW480/KrasRz was significantly smaller than that of XeSW480/DisKrasRz (P< 0.01, Dunnett’s test). Gene expression of VEGF was suppressed in SW480/KrasRz, while TSP1 gene expression was enhanced. The SW480/KrasRz cells showed apoptosis-related features including nuclear condensation and DNA fragmentation. These results suggested that the hammerhead ribozyme-mediated inactivation of the mutated K-ras mRNA induced growth suppression, apoptosis and alteration of angiogenic factor expression. © 2000 Cancer Research Campaig
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