Fabrication of 45 degrees template grain boundary junctions using a CaO lift-off technique

45 degrees grain boundary junctions have been made using (100) MgO substrates, a CeO2 template layer and an YBa2Cu3O7 top layer. To minimize the damage to the MgO surface, which will occur if the CeO2 is structured using ion milling, the CeO2 layer has been structured using the CaO lift-off technique. Electrical measurements of these junctions as a function of temperature, microwave irradiation and magnetic field will be discussed in this paper

Multilayer studies and applications in template bi-epitaxial DC SQUIDS

Multilayer deposition for the creation of a well-defined grain boundary, based on different in-plane orientations of c-axis oriented thin YBa2O2Cu3O7-δ layers on a single substrate, has been performed on three different kinds of substrates: (1102)-oriented Al2O3 , (100) SrTiO3, and (100) MgO. The multilayers consist of combinations of SrTiO3, MgO, CeO2, and YBa2O2Cu3O7-δ. The YBa 2O2Cu3O7-δ top layers on (1102) Al2O3 and (100) SrTiO3 were polycrystalline. Josephson junctions and DC superconducting quantum interference devices (SQUIDs) have been structured in the layers on MgO. Shapiro steps were observed. The Jcρn-product of the junctions at 4.2 K is on the order of 1 mV. The critical current decreases in good approximation linearly with increasing temperature, whereas the normal state resistance is nearly temperature independent. Voltage modulation was observed at temperatures up to 77 K

Coexistence of antiferrodistortive and ferroelectric distortions at the PbTiO3_3 (001) surface

The c(2$\times$2) reconstruction of (001) PbTiO$_3$ surfaces is studied by means of first principles calculations for paraelectric (non-polar) and ferroelectric ([001] polarized) films. Analysis of the atomic displacements in the near-surface region shows how the surface modifies the antiferrodistortive (AFD) instability and its interaction with ferroelectric (FE) distortions. The effect of the surface is found to be termination dependent. The AFD instability is suppressed at the TiO$_2$ termination while it is strongly enhanced, relative to the bulk, at the PbO termination resulting in a c(2x2) surface reconstruction which is in excellent agreement with experiments. We find that, in contrast to bulk PbTiO$_3$, in-plane ferroelectricity at the PbO termination does not suppress the AFD instability. The AFD and the in-plane FE distortions are instead concurrently enhanced at the PbO termination. This leads to a novel surface phase with coexisting FE and AFD distortions which is not found in PbTiO$_3$ bulk

Transport processes and reduction of I_cR_n product in YBa₂Cu₃O_x/PrBa₂Cu₃O_x/YBa₂Cu₃O_x ramp-type Josephson junctions

The mechanisms of current passage and the causes of IcRn (critical-current normal-resistance) product reduction of YBCO/PBCO/YBCO ramp-type junctions are analyzed. At PBCO (PrBa2Cu3Ox ) barrier thicknesses L=8-20 nm the junction characteristics are determined by the thickness of the PBCO barrier and its nature. The boundary resistance and depression of the YBCO (YBa2Cu3Ox) superconducting parameters near the interface do not strongly affect the junction parameters. The behaviour of the YBCO/PBCO/YBCO junctions cannot be described by simple SNS (superconductor-normal metal-superconductor) weak-link or SIS (superconductor-insulator-superconductor) tunnel models. A strong pair-breaking effect and a one-center inelastic tunneling process are taken into account to explain the Josephson and normal state characteristics of these junction

Effective treatment of liver metastases with photodynamic therapy, using the second-generation photosensitizer meta-tetra(hydroxyphenyl)chlorin (mTHPC), in a rat model

The only curative treatment for patients with liver metastases to date is surgery, but few patients are suitable candidates for hepatic resection. The majority of patients will have to rely on other treatment modalities for palliation. Photodynamic therapy (PDT) could be a selective, minimally invasive treatment for patients with liver metastases. We studied PDT in an implanted colon carcinoma in the liver of Wag/Rij rats, using the photosensitizer meta-tetra(hydroxyphenyl)chlorin (mTHPC). mTHPC tissue kinetics were studied using ex vivo extractions and in vivo fluorescence measurements. Both methods showed that mTHPC kinetics were different for liver and tumour tissue. After initial high levels at 4 h after administration (0.1 and 0.3 mg kg−1) mTHPC in liver tissue decreased rapidly in time. In tumour tissue no decrease in photosensitizer levels occurred, with mTHPC remaining high up to 48 h after administration. Both concentration data and fluorescence data showed an increase in tumour to liver ratios of up to 6.3 and 5.0 respectively. Illumination with 652 nm (15 J) resulted in extensive damage to tumour tissue, with necrosis of up to 13 mm in diameter. Damage to normal liver tissue was mild and transient as serum aspartate aminotransferase and alanine aminotransferase levels normalized within a week after PDT treatment. Long-term effects of mTHPC-PDT were studied on day 28 after treatment. Regardless of drug dose and drug–light interval, PDT with mTHPC resulted in complete tumour remission in 27 out of 31 treated animals (87%), with only four animals in which tumour regrowth was observed. Non-responding tumours proved to be significantly larger (P < 0.001) in size before PDT treatment. This study demonstrates that mTHPC is retained in an intrahepatic tumour and that mTHPC-PDT is capable of inducing complete tumour remission of liver tumours. © 1999 Cancer Research Campaig

Near‐millimeter‐wave response of high Tc ramp‐type Josephson junctions

We have studied the response of a YBCO/PBCO/YBCO ramp‐type junction to coherent radiation at 176 and 270 GHz. The I‐V characteristic of the junction closely resembles the prediction of the RSJ model. The I cR n product of the junction is 0.25 mV at 5 K. The millimeter‐wave radiation is coupled to the junction via a quasioptical structure that focuses the radiation onto the junction through a yttrium‐stabilized ZrO2 substrate. At 176 GHz, we have observed as many as six Shapiro steps at the maximum power level of our Gunn oscillator‐pumped frequency doubler. Shapiro steps are still clearly seen up to 65 K. The amplitudes of the zeroth, first, and second Shapiro steps, as functions of the square root of the radiation power, agree remarkably well with a Bessel function fit, indicating the junction is voltage‐biased at the radiation frequency (rf). At 270 GHz, due to a combination of the heavy rf loss in the ZrO2 substrate and the lack of radiation power, we have observed only the first Shapiro step

The Effects of Long-Term Graft Preservation on Intraoperative Hemostatic Changes in Liver Transplantation

We compared hemostatic changes during OLT and HLT after various periods of graft storage, to investigate whether the host liver in HLT protects the recipient from hemostatic deterioration induced by severe graft storage damage. In particular, the mechanism of fibrinolytic deterioration was investigated. The effect of prostaglandin E1 (PGE1) on these parameters was also studied