Human embryos from overweight and obese women display phenotypic and metabolic abnormalities

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization they reach the morula stage faster and, as blastocysts, show reduced glucose consumption and elevated endogenous triglyceride levels. WHAT IS KNOWN ALREADY Female overweight and obesity is associated with infertility. Moreover, being overweight or obese around conception may have significant consequences for the unborn child, since there are widely acknowledged links between events occurring during early development and the incidence of a number of adult disorders. STUDY DESIGN, SIZE, DURATION We have performed a retrospective, observational analysis of oocyte size and the subsequent developmental kinetics of 218 oocytes from 29 consecutive women attending for ICSI treatment and have related time to reach key developmental stages to maternal bodyweight. In addition, we have measured non-invasively the metabolic activity of 150 IVF/ICSI embryos from a further 29 consecutive women who donated their surplus embryos to research, and have related the data retrospectively to their body mass index (BMI). PARTICIPANTS/MATERIALS, SETTING, METHODS In a clinical IVF setting, we compared oocyte morphology and developmental kinetics of supernumerary embryos collected from overweight and obese women, with a BMI in excess of 25 kg/m2 to those from women of healthy weight. A Primovision Time-Lapse system was used to measure developmental kinetics and the non-invasive COnsumption/RElese of glucose, pyruvate, amino acids and lactate were measured on spent droplets of culture medium. Total triglyceride levels within individual embryos were also determined. MAIN RESULTS AND THE ROLE OF CHANCE Human oocytes from women presenting for fertility treatment with a BMI exceeding 25 kg/m2 are smaller (R2 = −0.45; P = 0.001) and therefore less likely to complete development post-fertilization (P < 0.001). Those embryos that do develop reach the morula stage faster than embryos from women of a BMI < 25 kg/m2

Trace gas transport in the subsurface of Mars

The ExoMars Trace Gas Orbiter (TGO) will have the capability of detecting and characterizing a broad suite of trace gases in the atmosphere of Mars. Interpreting the results of this mission will require an understanding of how these trace gases are transported from their sources, which may be deep underground, to the atmosphere. Here we present results of modeling designed to measure the timescales of release from putative subsurface methane sources. These transport timescales are far longer than mixing times in the atmosphere and could be up to 10 million years

Rates of referable eye disease in the Scottish National Diabetic Retinopathy Screening Programme

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher PD

Pattern Reduction in Paper Cutting

A large part of the paper industry involves supplying customers with reels of specified width in specifed quantities. These 'customer reels' must be cut from a set of wider 'jumbo reels', in as economical a way as possible. The first priority is to minimize the waste, i.e. to satisfy the customer demands using as few jumbo reels as possible. This is an example of the one-dimensional cutting stock problem, which has an extensive literature. Greycon have developed cutting stock algorithms which they include in their software packages. Greycon's initial presentation to the Study Group posed several questions, which are listed below, along with (partial) answers arising from the work described in this report. (1) Given a minimum-waste solution, what is the minimum number of patterns required? It is shown in Section 2 that even when all the patterns appearing in minimum-waste solutions are known, determining the minimum number of patterns may be hard. It seems unlikely that one can guarantee to find the minimum number of patterns for large classes of realistic problems with only a few seconds on a PC available. (2) Given an n → n-1 algorithm, will it find an optimal solution to the minimum- pattern problem? There are problems for which n → n - 1 reductions are not possible although a more dramatic reduction is. (3) Is there an efficient n → n-1 algorithm? In light of Question 2, Question 3 should perhaps be rephrased as 'Is there an efficient algorithm to reduce n patterns?' However, if an algorithm guaranteed to find some reduction whenever one existed then it could be applied iteratively to minimize the number of patterns, and we have seen this cannot be done easily. (4) Are there efficient 5 → 4 and 4 → 3 algorithms? (5) Is it worthwhile seeking alternatives to greedy heuristics? In response to Questions 4 and 5, we point to the algorithm described in the report, or variants of it. Such approaches seem capable of catching many higher reductions. (6) Is there a way to find solutions with the smallest possible number of single patterns? The Study Group did not investigate methods tailored specifically to this task, but the algorithm proposed here seems to do reasonably well. It will not increase the number of singleton patterns under any circumstances, and when the number of singletons is high there will be many possible moves that tend to eliminate them. (7) Can a solution be found which reduces the number of knife changes? The algorithm will help to reduce the number of necessary knife changes because it works by bringing patterns closer together, even if this does not proceed fully to a pattern reduction. If two patterns are equal across some of the customer widths, the knives for these reels need not be changed when moving from one to the other

A Semi-Analytical Analysis of Texture Collapse

This study presents a simplified approach to studying the dynamics of global texture collapse. We derive equations of motion for a spherically symmetric field configuration using a two parameter ansatz. Then we analyse the effective potential for the resulting theory to understand possible trajectories of the field configuration in the parameter space of the ansatz. Numerical results are given for critical winding and collapse time in spatially flat non-expanding, and flat expanding universes. In addition, the open non-expanding and open-expanding cases are studied.Comment: 12 pages, figures available from author, BROWN-HET-895, uses phyzz

Constraints on the Huygens landing site topography from the Surface Science Package Acoustic Properties Instrument

We present analysis of the results from the Huygens acoustic sounder instrument. The sounder sees a relatively smooth terrain, with specular reflectance characteristics

End stage renal disease and survival in people with diabetes:a national database linkage study

© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. Funding This work was supported by the Wellcome Trust through the Scottish Health Informatics Programme (SHIP). The SHIP is collaboration between the Universities of Aberdeen, Dundee, Edinburgh, Glasgow and St Andrews and the Information Services Division of National Health Service National Service Scotland. Funding for diabetes register linkage and data extraction was provided by the Chief Scientist’s Office of the Scottish Government. The Scottish Diabetes Research Network receives financial support from National Health Services Research Scotland. The Scottish Renal Registry is funded by the Information Services Division of National Health Service National Services Scotland but relies heavily on the goodwill of the contributing renal units who spent a large amount time working with Scottish Renal Registry staff to ensure that the data held within the register are accurate and complete.Peer reviewedPublisher PD

Zero mode quantization of multi-Skyrmions

A zero mode quantization of the minimal energy SU(2) Skyrmions for nucleon numbers four to nine and seventeen is described. This involves quantizing the rotational and isorotational modes of the configurations. For nucleon numbers four, six and eight the ground states obtained are in agreement with the observed nuclear states of Helium, Lithium and Beryllium. However, for nucleon numbers five, seven, nine and seventeen the spins obtained conflict with the observed isodoublet nuclear states.Comment: 37 pages, LaTeX, 4 figures. More careful treatment of double covers, reference adde

Beagle 2: Mission to Mars — current status

Beagle 2, developed in the UK, was launched on June 2, 2003. It landed on Mars on December 25th, 2003 in Isidis Planitia, a large sedimentary basin. To date, the team is awaiting signals from the Beagle 2 lander. Current status of the mission will be reported