© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. Funding This work was supported by the Wellcome Trust through the Scottish Health Informatics Programme (SHIP). The SHIP is collaboration between the Universities of Aberdeen, Dundee, Edinburgh, Glasgow and St Andrews and the Information Services Division of National Health Service National Service Scotland. Funding for diabetes register linkage and data extraction was provided by the Chief Scientist’s Office of the Scottish Government. The Scottish Diabetes Research Network receives financial support from National Health Services Research Scotland. The Scottish Renal Registry is funded by the Information Services Division of National Health Service National Services Scotland but relies heavily on the goodwill of the contributing renal units who spent a large amount time working with Scottish Renal Registry staff to ensure that the data held within the register are accurate and complete.Peer reviewedPublisher PD

Bell, S.

Brady, I.

Colhoun, H. M.

Conway, B.

Fletcher, E. H.

Halbesma, N.

Joss, N.

Leese, G.

Levin, D.

Lindsay, R. S.

Livingstone, S.

Looker, H. C.

Mcknight, J.

Metcalfe, W.

Pearson, D.

Philip, S.

Sattar, N.

Traynor, J. P.

Wild, S.

English

PubMed

worldwide is projected to lead to an increase in pa-tients with end-stage renal disease (ESRD) requiring renal replacement therapy (RRT). Aim: To provide contemporary estimates of the prevalence of ESRD and requirement for RRT among people with diabetes in a nationwide study and to report associated survival. Methods: Data were extracted and linked from thre

S. Bell

E. H. Fletcher

I. Brady

H. C. Looker

D. Levin

N. Joss

J. P. Traynor

W. Metcalfe

B. Conway

S. Livingstone

G. Leese

S. Philip

S. Wild

N. Halbesma

N. Sattar

R. S. Lindsay

J. Mcknight

D. Pearson

CiteSeerX

End-stage renal disease and survival in people with diabetes: a national database linkage study

E.H. Fletcher

H.C. Looker

J.P. Traynor

R.S. Lindsay

J. McKnight

H.M. Colhoun

Crossref

Background: Increasing prevalence of diabetes worldwide is projected to lead to an increase in patients with end stage renal disease (ESRD) requiring renal replacement therapy (RRT).Aim: To provide contemporary estimates of the prevalence of ESRD and requirement for RRT among people with diabetes in a nationwide study and to report associated survival.Methods: Data were extracted and linked from three national databases: Scottish Renal Registry, Scottish Care Initiative-Diabetes Collaboration and National Records of Scotland death data. Survival analyses were modelled with Cox regression.Results: Point prevalence of Chronic Kidney Disease (CKD)5 in 2008 was 1.63% of 19,414 people with type 1 diabetes (T1DM) compared to 0.58% of 167,871 people with type 2 diabetes (T2DM) (Odds ratio for DM type 0.97, p=0.77, on adjustment for duration Whilst 83% of those with T1DM and CKD5 and 61% of those with T2DM and CKD5 were receiving RRT, there was no difference when adjusted for age, sex and DM duration (Odds ratio for DM type 0.83, p=0.432). Diabetic nephropathy was the Primary Renal Diagnosis (PRD) in 91% of people with T1DM and 58% of people with T2DM on RRT. Median survival time from initiation of RRT was 3.84 years (95% CI 2.77, 4.62) in T1DM and 2.16 years (95% CI 1.92, 2.38) in T2DM.Conclusion: Considerable numbers of patients with diabetes continue to progress to CKD5 and RRT. Almost half of all RRT cases in T2DM are considered to be due to conditions other than diabetic nephropathy. Median survival time for people with diabetes from initiation of RRT remains poor. These prevalence data are important for future resource planning

McKnight, J.

Discovery Research Portal

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Dialysis delayed is death prevented: a clinical perspective on the RENAAL study. Kidney Int

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End stage renal disease and survival in people with diabetes

Federation. IDF Diabetes Atlas. 6th edn.

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care

Incidence of end-stage renal disease in patients with type 1 diabetes. JAMA

Incidence of ESRD and survival after renal replacement therapy in patients with type 1 diabetes: a report from the Allegheny County Registry. Am J Kidney Dis

Incidence of renal replacement therapy (RRT) in the diabetic compared with the non-diabetic population in a German region, 2002-08. Nephrol Dial Transpl

KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease.

Non-diabetic renal disease in type 2 diabetes mellitus. Nephrology

Nondiabetic renal disease in Type 2 diabetic patients: a review of our experience in 220 cases. Ren Fail

Patterns of renal injury in NIDDM patients with microalbuminuria. Diabetologia

Prevalence and causes of albuminuria in non-insulin-dependent diabetic-patients. Kidney Int

Prevalence of complications in IDDM by sex and duration.

Renal dysfunction in the presence of normoalbuminuria in Type 2 diabetes: results from the DEMAND study. Cardiorenal Med

Renal outcomes in patients with type 2 diabetes with or without coexisting non-diabetic renal disease. Diabetes Res Clin Pract

Renal replacement therapy for diabetic end-stage renal disease: data from 10 registries in Europe (1991–2000). Kidney Int

Renal replacement therapy in Europe: a summary of the 2011 ERA–EDTA Registry Annual Report. Clin Kidney J

Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage study. PLoS Med

Survey Monitoring Group. Scottish Diabetes Survey

SurveyMonitoring Group. Scottish Diabetes Survey2003.Scotland:NHSNationalServices.www.scotland.

The Scottish Care Information–Diabetes Collaboration (SCI-DC): Scottish Executive,

UK Renal Registry 16th annual report: chapter 5 comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland from 2011 to 2012. Nephron Clin Pract

United States Renal Data System

End stage renal disease and survival in people with diabetes:a national database linkage study

Background: Increasing prevalence of diabetes worldwide is projected to lead to an increase in patients with end-stage renal disease (ESRD) requiring renal replacement therapy (RRT).Aim: To provide contemporary estimates of the prevalence of ESRD and requirement for RRT among people with diabetes in a nationwide study and to report associated survival.Methods: Data were extracted and linked from three national databases: Scottish Renal Registry, Scottish Care Initiative-Diabetes Collaboration and National Records of Scotland death data. Survival analyses were modelled with Cox regression.Results: Point prevalence of chronic kidney disease (CKD) 5 in 2008 was 1.63% of 19 414 people with type 1 diabetes (T1DM) compared with 0.58% of 167 871 people with type 2 diabetes (T2DM) (odds ratio for DM type 0.97, P=0.77, on adjustment for duration. Although 83% of those with T1DM and CKD5 and 61% of those with T2DM and CKD5 were receiving RRT, there was no difference when adjusted for age, sex and DM duration (odds ratio for DM type 0.83, P = 0.432). Diabetic nephropathy was the primary renal diagnosis in 91% of people with T1DM and 58% of people with T2DM on RRT. Median survival time from initiation of RRT was 3.84 years (95% CI 2.77, 4.62) in T1DM and 2.16 years (95% CI: 1.92, 2.38) in T2DM.Conclusion: Considerable numbers of patients with diabetes continue to progress to CKD5 and RRT. Almost half of all RRT cases in T2DM are considered to be due to conditions other than diabetic nephropathy. Median survival time for people with diabetes from initiation of RRT remains poor. These prevalence data are important for future resource planning.</p

?, ?

Edinburgh Research Explorer

End-stage renal disease and survival in people with diabetes:a national database linkage study

© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. Funding This work was supported by the Wellcome Trust through the Scottish Health Informatics Programme (SHIP). The SHIP is collaboration between the Universities of Aberdeen, Dundee, Edinburgh, Glasgow and St Andrews and the Information Services Division of National Health Service National Service Scotland. Funding for diabetes register linkage and data extraction was provided by the Chief Scientist’s Office of the Scottish Government. The Scottish Diabetes Research Network receives financial support from National Health Services Research Scotland. The Scottish Renal Registry is funded by the Information Services Division of National Health Service National Services Scotland but relies heavily on the goodwill of the contributing renal units who spent a large amount time working with Scottish Renal Registry staff to ensure that the data held within the register are accurate and complete.Peer reviewe

Bell, S

Fletcher, E H

Brady, I

Looker, H C

Levin, D

Joss, N

Traynor, J P

Metcalfe, W

Conway, B

Livingstone, S

Leese, G

Philip, S

Wild, S

Halbesma, N

Sattar, N

Lindsay, R S

McKnight, J

Pearson, D

Colhoun, H M

Scottish Diabetes Research Network and Scottish Renal Registry

Aberdeen University Research

End-stage renal disease and survival in people with diabetes : a national database linkage study

http://qjmed.oxfordjournals.org/content/qjmed/early/2014/09/11/qjmed.hcu170.full.pdf

End stage renal disease and survival in people with diabetes:a national database linkage study

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