An Electrical Stimulus Which Can Be Accurately Measured

The difficulty encountered in the past with any technique involving the use of an electrical stimulus has been that of obtaining a stimulating current which could at once be easily varied and accurately measured. In order to make it possible to vary the necessarily high voltage involved, an induction coil or transformer was usually used as the source of electrical current. Since these instruments have an alternating current output it is therefore difficult to obtain a meter capable of measuring the very small current that can be used as a stimulant. The ordinary A. C. meters are not adapted for measurement of very weak currents. In lieu of current measurement it has been customary to measure the applied E.M.F. Voltage, however, is an unreliable indicator of the energy put into the stimulus. The uncontrolled factor of variable skin and body resistance effects a corresponding variation in current, which is independent of the applied voltage

Accommodation to hyperpolarization of human axons assessed in the frequency domain

Human axonsin vivowere subjected to subthreshold currents with a threshold-"ZAP" profile (Impedance [ Z: ] A: mplitude P: rofile) to allow the use of frequency domain techniques to determine the propensity for resonant behavior, and to clarify the relative contributions of different ion channels to their low-frequency responsiveness. Twenty-four studies were performed on the motor and sensory axons in 6 subjects. The response to oscillatory currents was tested between 'DC' and 16 Hz. A resonant peak at ~2 to 2.5 Hz was found in the response of hyperpolarized axons, but there was only a small broad response in axons at resting membrane potential (RMP). A mathematical model of axonal excitability developed using DC pulses provided a good fit to the frequency response for human axons, and indicated that the hyperpolarization-activated currentIh, and the slow potassium currentIKsare principally responsible for the resonance. However the results indicate that if axons are hyperpolarized more than -60% of resting threshold, the only conductances that are appreciably active areIhand the leak conductance - i.e., that the activity of these conductances can be studiedin vivovirtually in isolation at hyperpolarized membrane potentials. Given that the leak conductance dampens resonance it is suggested that the -60% hyperpolarization used here is optimal forIh As expected differences between the frequency responses of motor and sensory axons were present and best explained by reduced GKs, up-modulation ofIhand increased persistent Na(+)current,INaP(due to depolarization of RMP) in sensory axons

Mediator Strategies in New Zealand: The Views of the Mediated

Mediation is a process in which an impartial neutral (or a chairman with no right of decision) assists the disputants in settling their differences. The mediator's role is to facilitate voluntary agreements by the parties themselves; the parties' final decision is their own and not the mediator's. A mediator (and, for that matter, a conciliator in a dispute of interest) tries to persuade the disputants to reach a voluntary agreement by using strategies that fall short of outright arbitration. Because the philosophy and practice of mediation tend often to be misunderstood, this paper examines some of these strategies and the importance attached to them by employers and union officers. It offers some insight into what industrial relations practitioners consider to be the strategies most likely to lead to successful mediation

Use of extended and prepared reference objects in experimental Fourier transform X-ray holography

The use of one or more gold nanoballs as reference objects for Fourier Transform holography (FTH) is analysed using experimental soft X-ray diffraction from objects consisting of separated clusters of these balls. The holograms are deconvoluted against ball reference objects to invert to images, in combination with a Wiener filter to control noise. A resolution of ~30nm, smaller than one ball, is obtained even if a large cluster of balls is used as the reference, giving the best resolution yet obtained by X-ray FTH. Methods of dealing with missing data due to a beamstop are discussed. Practical prepared objects which satisfy the FTH condition are suggested, and methods of forming them described.Comment: 7 pages, 2 figures, submitted to Applied Physics Letter

Energy Access and Electricity Planning

As developing countries look for ways to achieve sustainable energy services, which is essential to lift people out of poverty, the big challenge centers around providing access for all while avoiding past pitfalls without creating new ones. The reality is that this can only occur if there is a fundamental transformation of energy systems along the entire set of resource to energy service chains - and that will necessitate greater energy efficiency and a bigger role for renewables in the global energy mix energy. Competitive and private sector dominated energy markets rely on clear and consistent government energy-environment policies to align their investment decisions with sustainable development objectives. This paper tries to shed light on how developing countries can carry out energy planning by reviewing the available methodologies and tools, including their potential to integrate rural energy access and encourage the uptake of renewable energy technologies. It also probes how investment needs and cost-effectiveness are reflected in different analytic and planning tools - with a case study on Ethiopia. And it examines the interaction of energy planning and scenario development and how these are applied to informed policy making. The findings suggest that energy planning is essential and feasible. However, support is required to improve data collection and access, develop open accessible modelling tools, and build sustainable national capacity to undertake plannin

SPEDEN: Reconstructing single particles from their diffraction patterns

Speden is a computer program that reconstructs the electron density of single particles from their x-ray diffraction patterns, using a single-particle adaptation of the Holographic Method in crystallography. (Szoke, A., Szoke, H., and Somoza, J.R., 1997. Acta Cryst. A53, 291-313.) The method, like its parent, is unique that it does not rely on ``back'' transformation from the diffraction pattern into real space and on interpolation within measured data. It is designed to deal successfully with sparse, irregular, incomplete and noisy data. It is also designed to use prior information for ensuring sensible results and for reliable convergence. This article describes the theoretical basis for the reconstruction algorithm, its implementation and quantitative results of tests on synthetic and experimentally obtained data. The program could be used for determining the structure of radiation tolerant samples and, eventually, of large biological molecular structures without the need for crystallization.Comment: 12 pages, 10 figure

The Dark Side of Top Level Sport: An Autobiographic Study of Depressive Experiences in Elite Sport Performers

The general and sport psychology research converge to point to a complex relationship between depressive experiences and human performance. The purpose of this study was to explore the depressive experiences of top level athletes and the relationship of such experiences with sport performance. Twelve autobiographies of elite athletes representing eight sports were analyzed. The autobiographical analysis was informed by narrative tradition, using three types of narrative analysis: categorical content, categorical form, and holistic content. The analysis revealed a temporal aspect to the depressive experiences that the athletes reported. Initially, sport represented a form of escape from the depressive symptoms which had been exacerbated by both external stressors (e.g., experiencing bereavement) and internal stressors (e.g., low self-esteem). However, in time, the athletes typically reached a stage when the demands of their sport shifted from being facilitative to being debilitative in nature with an intensification of their depressive symptoms. This was accompanied by deliberations about continuing their engagement in sport and an acceptance that they could no longer escape from their symptoms, with or without sport. The findings extend the extant literature by suggesting a reciprocal relationship between depressive experiences and sport performance, and they support the general psychology literature relating to the negative impact of depression on performance. The applied implications of these findings are discussed emphasizing the importance of early identification of depressive symptoms and the adoption of a proactive approach in the prevention and management of symptoms

Phasing diffuse scattering. Application of the SIR2002 algorithm to the non-crystallographic phase problem

A new phasing algorithm has been used to determine the phases of diffuse elastic X-ray scattering from a non-periodic array of gold balls of 50 nm diameter. Two-dimensional real-space images, showing the charge-density distribution of the balls, have been reconstructed at 50 nm resolution from transmission diffraction patterns recorded at 550 eV energy. The reconstructed image fits well with scanning electron microscope (SEM) image of the same sample. The algorithm, which uses only the density modification portion of the SIR2002 program, is compared with the results obtained via the Gerchberg-Saxton-Fienup HIO algorithm. In this way the relationship between density modification in crystallography and the HiO algorithm used in signal and image processing is elucidated.Comment: 7 pages, 12 figure

The neurobiology of methamphetamine induced psychosis

Chronic methamphetamine abuse commonly leads to psychosis, with positive and cognitive symptoms that are similar to those of schizophrenia. Methamphetamine induced psychosis (MAP) can persist and diagnoses of MAP often change to a diagnosis of schizophrenia over time. Studies in schizophrenia have found much evidence of cortical GABAergic dysfunction. Methamphetamine psychosis is a well studied model for schizophrenia, however there is little research on the effects of methamphetamine on cortical GABAergic function in the model, and the neurobiology of MAP is unknown. This paper reviews the effects of methamphetamine on dopaminergic pathways, with focus on its ability to increase glutamate release in the cortex. Excess cortical glutamate would likely damage GABAergic interneurons, and evidence of this disturbance as a result of methamphetamine treatment will be discussed. We propose that cortical GABAergic interneurons are particularly vulnerable to glutamate overflow as a result of subcellular location of NMDA receptors on interneurons in the cortex. Damage to cortical GABAergic function would lead to dysregulation of cortical signals, resulting in psychosis, and further support methamphetamine induced psychosis as a model for schizophrenia

The Ursinus Weekly, January 23, 1928

Ursinus team to play Eastern Pennsylvania league leaders Monday evening • Paul Lefever placed sixth in tennis rank • Ursinus women\u27s affirmative defeats Schuylkill negative here Tuesday evening • Girls\u27 team defeats high school Monday • 1928 Ruby gives promise as best annual published • Dr. Ralph Johnson delivers lecture to Biology Club • Plans being made for Athletic Association bazaar • Bears beat Haverford but lose to Temple in hard-fought games • Members of Ursinus faculty present at conferences • Mid-year dance Saturday • English Club discusses modern essays on Thursday • Brotherhood of St. Paul • Dr. Jordan entertains team • The Voice of Dusk • Temple frosh defeat Ursinus J. V. Thursday • Schaff Literary Society • Zwinglian Literary Societyhttps://digitalcommons.ursinus.edu/weekly/2205/thumbnail.jp