Solar Light Induced Photo Catalytic Properties of α-Fe2O3 Nanoparticles for Degradation of Methylene Blue Dye

The present work describes α-Fe2O3 nanoparticles are prepared by chemical displacement method using CTAB as a stabilizing agent. Glutaric acid as fuel and metal salt like ferrous sulphate was used in synthesis. The structural, morphological, metal percentage and optical properties of as synthesized nanoparticles are investigated by using x-ray diffraction (XRD), UV-Visible Spectra; field emission gun Scanning electron microscopy (FEG-SEM) with EDS, Fourier transforms infrared spectroscopy (FTIR), High-resolution Transmission electron microscopy (HR-TEM) and Photoluminescence Spectroscopy (PL). The photocatalytic degradation of Methylene Blue dye was measured by visible absorption spectroscopy. To obtain the most favorable conditions for degradation of MB dye, the effect of various experimental parameters, i.e., pH, amount of nanoparticles, concentration of dye and light intensity on the rate of reaction was studied. A tentative mechanism for the photocatalytic degradation of Methylene Blue was proposed. Photocatalytic degradation of Methylene Blue dye followed pseudo first-order kinetics. It was found that the dye degradation gave the best results at a pH of 6.0, and using a 70 mW•cm–2 light intensity with 0.3 g of α-Fe2O3 nanoparticles. At room temperature, the photocatalytic degradation of Methylene Blue dye was observed about 92.3%

Adsorption of Eriochrome Black-T dye by batch investigations using waste tea@Fe NPs as low-cost adsorbent

This work has examined the efficaciousness of iron nanoparticles made from tea waste extract in the elimination of Eriochrome black T (EBT) dye. Field emission gun scanning electron microscopy (FEG-SEM) with EDAX, High- resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), and FTIR spectroscopy were used to evaluate the synthesized iron capped nanoparticles. Iron nanoparticles seemed amorphous, according to the X-ray diffraction patterns. The spherical form of the Fe NPs was discernibly shown by scanning electron microscopy. Particle size of Fe NPs is found to be in the 30–40 nm range using transmission electron microscopy (HR-TEM). Additionally, research was done on the deterioration of the Eriochrome black T pigment (EBT). It was investigated how several experimental factors, such as the amount of adsorbent, pH, dye concentration, and contact duration, affected the pace of reaction in order to determine the ideal conditions for dye degradation. There are pseudo-first-order kinetics involved in the adsorption of the dye Eriochrome black T (EBT). At a pH of 3, 50 ppm of Eriochrome Black T (EBT) dye concentration, and 0.60 g of adsorbent, the dye degradation was observed to exhibit optimized results. The highest dye elimination was accomplished by stirring for 90 minutes at a Room temperature

The ACT-ONE trial, a multicentre, randomised, double-blind, placebo-controlled, dose-finding study of the anabolic/catabolic transforming agent, MT-102 in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal cancer: study design

Aims Cachexia, the wasting disorder associated with a wide range of serious illnesses including cancer, is a major cause of morbidity and mortality. There is currently no widely approved therapeutic agent for treating or preventing cancer-associated cachexia. Colorectal cancer and nonsmall cell lung cancer have relatively high incidences of cachexia, approximately 28% and 34%, respectively. Neurohormonal overactivity has been implicated in the genesis and progression of cachexia and beta receptor antagonism has been proposed as a potential therapy. MT-102, a novel anabolic/catabolic transforming agent, has a multi-functional effect upon three potential pharmacological targets in cancer cachexia, namely reduced catabolism through non-selective β-blockade, reduced fatigue, and thermogenesis through central 5-HT1a antagonism and increased anabolism through partial β-2 receptor agonism. Methods At least 132 male and female patients, aged between 25 and 80 years with a confirmed diagnosis of late-stage non-small cell lung cancer or colorectal cancer, with cachexia will be randomised to either one of the two MT-102 doses or placebo in a 3:1:2 ratio (MT-102 10 mg BD−1/MT-102 2.5 mg BD/placebo). Patients will continue on study treatment for maximally 16 weeks. The primary endpoint, to be analysed by assigned treatment group, will be body weight change over 16 weeks. For this endpoint, the study has 85% power (0.05% significance level) to detect per 4-week period a mean change of −0.8 kg in the placebo group and 0 kg in the high-dose MT-102 arm. The first patient was randomised in February 2011 and patient recruitment is expected to continue until mid-2012. Perspective The ACT-ONE trial is designed to test whether the anabolic/catabolic transforming agent MT-102 will positively impact on the rate of change of body weight in cancer cachexia, thereby evaluating a novel therapeutic strategy in this hitherto poorly treatable condition. A separate ACT-TWO trial will recruit patients who complete the ACT-ONE trial and remain on randomised double-blind medication. Participants in ACT-TWO will be followed for an additional period with a separate primary endpoint

Apoptosis induction capability of silver nanoparticles capped with Acorus calamus L. and Dalbergia sissoo Roxb. Ex DC. against lung carcinoma cells

Silver nanoparticles (AgNPs) were prepared using a one-step reduction of silver nitrate (AgNO3) with sodium borohydride (NaBH4) in the presence of polyvinylpyrrolidone (PVP) as a capping agent. Plant extracts from D. sissoo (DS) and A. calamus L. (AC) leaves were incorporated during the synthesis process. The crystalline nature of the AgNPs was confirmed through X-ray diffraction (XRD), confirming the face-centered cubic structure, with a lattice constant of 4.08 Å and a crystallite size of 18 nm. Field Emission Gun Transmission Electron Microscopy (FEG-TEM) revealed spherical AgNPs (10–20 nm) with evident PVP adsorption, leading to size changes and agglomeration. UV–Vis spectra showed a surface plasmon resonance (SPR) band at 417 nm for AgNPs and a redshift to 420 nm for PVP-coated AgNPs, indicating successful synthesis. Fourier Transform Infrared Spectroscopy (FTIR) identified functional groups and drug-loaded samples exhibited characteristic peaks, confirming effective drug loading. The anti-cancer potential of synthesized NPs was assessed by MTT assay in human adenocarcinoma lung cancer (A549) and lung normal cells (WI-38) cells. IC50 values for all three NPs (AgPVP NPs, DS@AgPVP NPs, and AC@AgPVP NPs) were 41.60 ± 2.35, 14.25 ± 1.85, and 21.75 ± 0.498 μg/ml on A549 cells, and 420.69 ± 2.87, 408.20 ± 3.41, and 391.80 ± 1.55 μg/ml respectively. Furthermore, the NPs generated Reactive Oxygen Species (ROS) and altered the mitochondrial membrane potential (MMP). Differential staining techniques were used to investigate the apoptosis-inducing properties of the three synthesized NPs. The colony formation assay indicated that nanoparticle therapy prevented cancer cell invasion. Finally, Real-Time PCR (RT-PCR) analysis predicted the expression pattern of many apoptosis-related genes (Caspase 3, 9, and 8)

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual