749 research outputs found
A Case Study: Changing Human Resource Management Education to Fit the Field
The field of Human Resource Management has embarked upon a process of significant change. To keep up with changes to the field, Barksdale (1998) argued that so too must HR education change. This article presents an effort that changed the HR educational model from a functional silos focused model to an integrated outcome-based model. The logic for the change, what changes were made, and comments about the outcomes are presented
Joint Modeling of Radial Velocities and Photometry with a Gaussian Process Framework
Developments in the stability of modern spectrographs have led to extremely
precise instrumental radial velocity (RV) measurements. For most stars, the
detection limit of planetary companions with these instruments is expected to
be dominated by astrophysical noise sources such as starspots. Correlated
signals caused by rotationally-modulated starspots can obscure or mimic the
Doppler shifts induced by even the closest, most massive planets. This is
especially true for young, magnetically active stars where stellar activity can
cause fluctuation amplitudes of 0.1 mag in brightness and 100
m s in RV semi-amplitudes. Techniques that can mitigate these effects
and increase our sensitivity to young planets are critical to improving our
understanding of the evolution of planetary systems. Gaussian processes (GPs)
have been successfully employed to model and constrain activity signals in
individual cases. However, a principled approach of this technique,
specifically for the joint modeling of photometry and RVs, has not yet been
developed. In this work, we present a GP framework to simultaneously model
stellar activity signals in photometry and RVs that can be used to investigate
the relationship between both time series. Our method, inspired by the
framework of (Aigrain et al. 2012), models spot-driven
activity signals as the linear combinations of two independent latent GPs and
their time derivatives. We also simulate time series affected by starspots by
extending the software (Luger et al. 2019) to incorporate
time evolution of stellar features. Using these synthetic datasets, we show
that our method can predict spot-driven RV variations with greater accuracy
than other GP approaches.Comment: 19 pages, 10 figure
Weakly correlated electrons on a square lattice: a renormalization group theory
We study the weakly interacting Hubbard model on the square lattice using a
one-loop renormalization group approach. The transition temperature T_c between
the metallic and (nearly) ordered states is found. In the parquet regime, (T_c
>> |mu|), the dominant correlations at temperatures below T_c are
antiferromagnetic while in the BCS regime (T_c << |mu|) at T_c the d-wave
singlet pairing susceptibility is most divergent.Comment: 12 pages, REVTEX, 3 figures included, submitted to Phys. Rev. Let
Quasiparticle dynamics and phonon softening in FeSe superconductors
Quasiparticle dynamics of FeSe single crystals revealed by dual-color
transient reflectivity measurements ({\Delta}R/R) provides unprecedented
information on Fe-based superconductors. The amplitude of fast component in
{\Delta}R/R clearly tells a competing scenario between spin fluctuations and
superconductivity. Together with the transport measurements, the relaxation
time analysis further exhibits anomalous changes at 90 K and 230 K. The former
manifests a structure phase transition as well as the associated phonon
softening. The latter suggests a previously overlooked phase transition or
crossover in FeSe. The electron-phonon coupling constant {\lambda} is found to
be 0.16, identical to the value of theoretical calculations. Such a small
{\lambda} demonstrates an unconventional origin of superconductivity in FeSe.Comment: Final published version; 5 pages; 4 figure
Superconductivity and Pseudogap in Quasi-Two-Dimensional Metals around the Antiferromagnetic Quantum Critical Point
Spin fluctuations (SF) and SF-mediated superconductivity (SC) in
quasi-two-dimensional metals around the antiferrromagnetic (AF) quantum
critical point (QCP) are investigated by using the self-consistent
renormalization theory for SF and the strong coupling theory for SC. We
introduce a parameter y0 as a measure for the distance from the AFQCP which is
approximately proportional to (x-xc), x being the electron (e) or hole (h)
doping concentration to the half-filled band and xc being the value at the
AFQCP. We present phase diagrams in the T-y0 plane including contour maps of
the AF correlation length and AF and SC transition temperatures TN and Tc,
respectively. The Tc curve is dome-shaped with a maximum at around the AFQCP.
The calculated one-electron spectral density shows a pseudogap in the
high-density-of-states region near (pi,0) below around a certain temperature T*
and gives a contour map at the Fermi energy reminiscent of the Fermi arc. These
results are discussed in comparison with e- and h-doped high-Tc cuprates.Comment: 5 pages, 3 figure
Thermoelectric Figure of Merit of Strongly Correlated Superlattice Semiconductors
We solved the Anderson Lattice Hamiltonian to get the energy bands of a
strongly correlated semiconductor by using slave boson mean field theory. The
transport properties were calculated in the relaxation-time approximation,and
the thermoelectric figure of merit was obtained for the strongly correlated
semiconductor and its superlattice structures. We found that at room
temperature can reach nearly 2 for the quantum wire lattice structure.We
believe that it is possible to find high values of thermoelectric figure of
merit from strongly correlated semiconductor superlattice systems.Comment: 4 pages, 3 figure
Dynamic Exponent of t-J and t-J-W Model
Drude weight of optical conductivity is calculated at zero temperature by
exact diagonalization for the two-dimensional t-J model with the two-particle
term, . For the ordinary t-J model with =0, the scaling of the Drude
weight for small doping concentration is
obtained, which indicates anomalous dynamic exponent =4 of the Mott
transition. When is switched on, the dynamic exponent recovers its
conventional value =2. This corresponds to an incoherent-to-coherent
transition associated with the switching of the two-particle transfer.Comment: LaTeX, JPSJ-style, 4 pages, 5 eps files, to appear in J. Phys. Soc.
Jpn. vol.67, No.6 (1998
Direct Calculation of Spin-Stiffness for Spin-1/2 Heisenberg Models
The spin-stiffness of frustrated spin-1/2 Heisenberg models in one and two
dimensions is computed for the first time by exact diagonalizations on small
clusters that implement spin-dependent twisted boundary conditions. Finite-size
extrapolation to the thermodynamic limit yields a value of for
the spin-stiffness of the unfrustrated planar antiferromagnet. We also present
a general discussion of the linear-response theory for spin-twists, which
ultimately leads to the moment sum-rule.Comment: 11 pgs, TeX, LA-UR-94-94 (to be published in Phys. Rev. B
Management of diarrhea in patients with HER2-positive breast cancer treated with neratinib: A case series and summary of the literature
INTRODUCTION: Neratinib and neratinib-based combinations have demonstrated efficacy for treatment of human epidermal growth factor receptor 2-positive (HER2+) early-stage and metastatic breast cancers. However, diarrhea has been reported as a common adverse event leading to neratinib discontinuation. Results from the CONTROL trial suggest that proactive diarrhea management with antidiarrheal prophylaxis or dose escalation of neratinib from a lower starting dose to the full FDA-approved dose of 240 mg/day can reduce the incidence, duration, and severity of neratinib-associated diarrhea in patients with early-stage breast cancer. Dose escalation has been included in the FDA-approved label for both early-stage and metastatic HER2+ breast cancer since June 2021.
CASE SERIES: This series of five cases details real-world clinical implementation of strategies for management of neratinib-induced diarrhea in patients with early-stage and metastatic HER2+ breast cancer, including a patient with a pre-existing gastrointestinal disorder.
MANAGEMENT AND OUTCOME: In four of five cases, diarrhea was managed with neratinib dose escalation, and antidiarrheal prophylaxis with loperamide plus colestipol was used in the remaining case. Management of diarrhea allowed all patients to remain on therapy.
DISCUSSION: This case series shows that neratinib-associated diarrhea can be managed effectively with neratinib dose escalation from a lower initial starting dose and/or prophylactic antidiarrheal medications in a real-world clinical setting. The findings highlight the importance of patient-provider communication in proactive management of adverse events. Widespread implementation of the strategies described here may improve adherence and thereby clinical outcomes for patients with HER2+ breast cancer treated with neratinib
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