Hip fracture, mortality risk, and cause of death over two decades

Summary: Men and women with hip fracture have higher short-term mortality. This study investigated mortality risk over two decades post-fracture; excess mortality remained high in women up to 10 years and in men up to 20 years. Cardiovascular disease (CVD) and pneumonia were leading causes of death with a long-term doubling of risk. Introduction: Hip fractures are associated with increased mortality, particularly short term. In this study with a two-decade follow-up, we examined mortality and cause of death compared to the background population. Methods: We followed 1013 hip fracture patients and 2026 matched community controls for 22 years. Mortality, excess mortality, and cause of death were analyzed and stratified for age and sex. Hazard ratio (HR) was estimated by Cox regression. A competing risk model was fitted to estimate HR for common causes of death (CVD, cancer, pneumonia) in the short and long term (>1 year). Results: For both sexes and at all ages, mortality was higher in hip fracture patients across the observation period with men losing most life years (p <0.001). Mortality risk was higher for up to 15 years (women (risk ratio (RR) 1.9 [95 % confidence interval (CI) 1.7–2.1]); men (RR 2.8 [2.2–3.5])) and until end of follow-up ((RR 1.8 [1.6–2.0]); (RR 2.7 [2.1–3.3])). Excess mortality by time intervals, censored for the first year, was evident in women (80 years, for 5 years) and in me

High Energy Quark-Antiquark Elastic scattering with Mesonic Exchange

We studies the high energy elastic scattering of quark anti-quark with an exchange of a mesonic state in the $t$ channel with $-t/\Lambda^{2} \gg 1$. Both the normalization factor and the Regge trajectory can be calculated in PQCD in cases of fixed (non-running) and running coupling constant. The dependence of the Regge trajectory on the coupling constant is highly non-linear and the trajectory is of order of $0.2$ in the interesting physical range.Comment: 29 page

Consequence of Hawking radiation from 2d dilaton black holes

We investigate the CGHS model through numerical calculation. The behavior of the mass function, which we introduced in our previous work as a ``local mass'', is examined. We found that the mass function takes negative values, which means that the amount of Hawking radiation becomes greater than the initial mass of the black hole as in the case of the RST model.Comment: 17pages, 5 figures (three of them are attached, the other 2 figures are available on request. Some mistakes including typographic errors have been correcte

Entropy of Extremal Black Holes in Two Dimensions

Entropy for two dimensional extremal black holes is computed explicitly in a finite-space formulation of the black hole thermodynamics and is shown to be zero {\it locally}. Our results are in conformity with the recent one by Hawking et al in four dimensions.Comment: 11 page

Flat World of Dilatonic Domain Walls

We study dilatonic domain walls specific to superstring theory. Along with the matter fields and metric the dilaton also changes its value in the wall background. We found supersymmetric (extreme) solutions which in general interpolate between isolated superstring vacua with non-equal value of the matter potential; they correspond to the static, planar domain walls with {\it flat} metric in the string (sigma model) frame. We point out similarities between the space-time of dilatonic walls and that of charged dilatonic black holes. We also comment on non-extreme solutions corresponding to expanding bubbles.Comment: 11 pgs (+2 figures available upon request), UPR-560-

Radiative Kaon Decays K±→π±π0γK^\pm\to\pi^\pm\pi^0\gamma and Direct CP Violation

It is stressed that a measurement of the electric dipole amplitude for direct photon emission in \kpm decays through its interference with inner bremsstrahlung is important for differentiating among various models. Effects of amplitude CP violation in the radiative decays of the charged kaon are analyzed in the Standard Model in conjunction with the large $N_c$ approach. We point out that gluon and electromagnetic penguin contributions to the CP-violating asymmetry between the Dalitz plots of \kpm are of equal weight. The magnitude of CP asymmetry ranges from $2\times 10^{-6}$ to $1\times 10^{-5}$ when the photon energy in the kaon rest frame varies from 50 MeV to 170 MeV.Comment: Latex, 11 pages, ITP-SB-93-36, IP-ASTP-22-9

Simultaneous cardiac surgery with pulmonary resection: presentation of series and review of literature 1

Abstract Background: The issue of performing simultaneous pulmonary resection and cardiac surgery in patients with coexisting lung carcinoma and ischaemic heart disease remains controversial. We report our experience and review the literature. Methods: Thirteen patients (male ten, female three; mean age 65 years) underwent simultaneous cardiac surgery and pulmonary resection. Lung pathology consisted of primary lung carcinoma (n = 10), benign disease (n = 2) and carcinoid (n = 1). Lung resections included pneumonectomy (n = 3), lobectomy (n = 4), segmentectomy (n = 1) and local excision (n = 5). Cardiac procedures consisted of coronary artery bypass grafting (CABG) in 11, aortic valve replacement in one and mitral valve repair with CABG in one patient. In all but one case the lung resection was performed prior to heparinization and cardiopulmonary bypass (CPB). In two patients, with suitable coronary anatomy, myocardial revascularization without CPB was performed to reduce morbidity. Results: There was no hospital mortality. Postoperative blood loss and ventilation requirements were reduced in the patients who were operated on without CPB. Prolonged ventilatory support was required in two cases. All patients with benign pathology are alive. In the lung cancer group there have been five late deaths: disseminated metastatic disease (n = 3), anticoagulant related haemorrhage (n = 1) and broncho-pleural fistula (n = 1). Of the remaining five patients four are alive and disease free 7-23 months post-operatively; one patient has recurrent disease 40 months post-operatively. Conclusions: Simultaneous pulmonary resection and cardiac surgery is associated with acceptable operative morbidity and mortality. In patients with lung carcinoma long-term survival was determined by tumour stage. The avoidance of CPB may be advantageous by decreasing blood loss and ventilation requirements

Open defecation and childhood stunting in India: an ecological analysis of new data from 112 districts.

Poor sanitation remains a major public health concern linked to several important health outcomes; emerging evidence indicates a link to childhood stunting. In India over half of the population defecates in the open; the prevalence of stunting remains very high. Recently published data on levels of stunting in 112 districts of India provide an opportunity to explore the relationship between levels of open defecation and stunting within this population. We conducted an ecological regression analysis to assess the association between the prevalence of open defecation and stunting after adjustment for potential confounding factors. Data from the 2011 HUNGaMA survey was used for the outcome of interest, stunting; data from the 2011 Indian Census for the same districts was used for the exposure of interest, open defecation. After adjustment for various potential confounding factors--including socio-economic status, maternal education and calorie availability--a 10 percent increase in open defecation was associated with a 0.7 percentage point increase in both stunting and severe stunting. Differences in open defecation can statistically account for 35 to 55 percent of the average difference in stunting between districts identified as low-performing and high-performing in the HUNGaMA data. In addition, using a Monte Carlo simulation, we explored the effect on statistical power of the common practice of dichotomizing continuous height data into binary stunting indicators. Our simulation showed that dichotomization of height sacrifices statistical power, suggesting that our estimate of the association between open defecation and stunting may be a lower bound. Whilst our analysis is ecological and therefore vulnerable to residual confounding, these findings use the most recently collected large-scale data from India to add to a growing body of suggestive evidence for an effect of poor sanitation on human growth. New intervention studies, currently underway, may shed more light on this important issue

Investigation of risk factors for introduction of highly pathogenic avian influenza H5N1 infection among commercial turkey operations in the United States, 2022: a case-control study

Introduction: The 2022–2023 highly pathogenic avian influenza (HPAI) H5N1 outbreak in the United States (U.S.) is the largest and most costly animal health event in U.S. history. Approximately 70% of commercial farms affected during this outbreak have been turkey farms. Methods: We conducted a case-control study to identify potential risk factors for introduction of HPAI virus onto commercial meat turkey operations. Data were collected from 66 case farms and 59 control farms in 12 states. Univariate and multivariable analyses were conducted to compare management and biosecurity factors on case and control farms. Results: Factors associated with increased risk of infection included being in an existing control zone, having both brooders and growers, having toms, seeing wild waterfowl or shorebirds in the closest field, and using rendering for dead bird disposal. Protective factors included having a restroom facility, including portable, available to crews that visit the farm and workers having access and using a shower at least some of the time when entering a specified barn. Discussion: Study results provide a better understanding of risk factors for HPAI infection and can be used to inform prevention and control measures for HPAI on U.S. turkey farms