Существует ли связь между средним уровнем mIDkIne и прогнозом заболевания COVID-19?

   The objective was aimed to measure plasma midkine (MK)* levels in patients with COVID-19 and assess its clinical significance.   Materials and Methods. 88 patients observed in our hospital with a diagnosis of COVID-19 were included in the study. The patients’ demographic characteristics, clinical, and laboratory data were studied, and the relationship between MK levels, prognosis, and other parameters was investigated.   Results. Of the 88 patients included in the study, 43 (48.9 %) were female and 45 (51.1%) were male. 24 (27%) patients died. The mean age of non-survivors was 70 ± 12.3 years and the survivors were 61.9 ± 18.2 years. Mortality predictors such as D-dimer, ferritin, troponin, LDH, CRP, and procalcitonin were significantly higher in non-survivors than in survivors (p < 0.05). The median MK level (IR) was 152.5 ± 125 pg/ml in all patients, 143 ± 149 pg/ml in survivors, and 165.5 ± 76 pg/ml in non-survivors (p = 0.546). The difference between these two groups was not statistically significant. The area under the ROC curve was found to be 0.542 (95% CI 0.423–0.661, p = 0.546).   Conclusion. MK is not a biomarker that can replace or reinforce known predictors of mortality in COVID-19 patients.   Цель. Исследование направлено на измерение уровня Midkine (MK)* в плазме крови у пациентов с COVID-19 и оценку его клинической значимости.   Материалы и методы. В исследование включены 88 пациентов, наблюдавшихся в клинике с диагнозом COVID-19. Изучены демографические характеристики пациентов, клинические и лабораторные данные, а также исследована взаимосвязь между уровнями MK, прогнозом и другими параметрами.   Результаты. Из 88 пациентов, включенных в исследование, 43 (48,9 %) были женщинами и 45 (51,1 %) – мужчинами. 24 (27 %) пациента умерли. Средний возраст невыживших составил 70 ± 12,3 года, а выживших – 61,9 ± 18,2 года. Предикторы смертности, такие как D-димер, ферритин, тропонин, ЛДГ, СРБ и прокальцитонин, были значительно выше у умерших, чем у выживших (р < 0,05). Медиана уровня МК (IR) составила 152,5 ± 125 пг/мл у всех пациентов, 143 ± 149 пг/мл у выживших и 165,5 ± 76 пг/мл у умерших (р = 0,546). Разница между этими 2 группами была незначима. Было обнаружено, что площадь под кривой ROC составляет 0,542 (95 % ДИ 0,423–0,661, р = 0,546).   Вывод. МК не является биомаркером, который может заменить или усилить известные предикторы смертности у пациентов с COVID-19

ANALELE STIINTIFICE ALE UNIVERSITATII AL I CUZA DIN IASI-SERIE NOUA-MATEMATICA

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IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE

In this paper, we give some characterizations for Legendre spherical, Legendre normal and Legendre rectifying curves in the 3-dimensional Sasakian space. Furthermore, we show that Legendre spherical curves are also Legendre normal curves. In particular, we prove that the inverse of curvature of a Legendre rectifying curve is a non-constant linear function of the arclength parameter

ANNALI DI MATEMATICA PURA ED APPLICATA

In this paper, we study spacelike and timelike curves of constant breadth in Minkowski 3-space. We show that in Minkowski 3-space spacelike and timelike curves of constant breadth are normal, helices, and spherical curves in some special cases. Furthermore, we give that the total torsion of a closed spacelike curve of constant breadth is zero while the total torsion of a simple closed timelike curve is equal to 2 pi n, (n is an element of Z)

IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE

1-type and biharmonic curves by using Laplace operator in Lorentzian 3-space are studied and some theorems and characterizations are given for these curves

IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE

In this study, the timelike curves of constant breadth according to Bishop frame in Minkowski 3-space are investigated. The differential equations characterizing the timelike curves of constant breadth in E-1(3) are given. In addition, it is shown that the timelike curves of constant breadth are related to slant helix in Minkowski 3-space E-1(3)

Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy

PMID = 3182003

HEMATOLOGICAL MARKERS OF THE NO-REFLOW PHENOMEN ON IN-PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

PMID = 2734816