57 research outputs found
Plasmaspheric Plumes: Crres Observations Of Enhanced Density Beyond The Plasmapause
CRRES plasma wave receiver density data were used to study the distribution and properties of dense plasmaspheric-like plasma observed outside the plasmapause. Our study indicates that outer plasmaspheric structure, often called plasmaspheric plumes, blobs, tails, or detached plasma regions, can exist at all local times under all levels of geomagnetic activity. Of the 558 CRRES orbits that had at least one clearly defined plasmapause, 169 (or 30%) had plasmaspheric-like density structures at higher L shells than the plasmapause. Most of the occurrences of plasmaspheric-like plasma observed by CRRES were in the noon-to-dusk sector in the aftermath of enhanced geomagnetic activity consistent with plasmaspheric plume models
The rarity of terrestrial gamma-ray flashes
We report on the first search for Terrestrial Gamma-ray Flashes (TGFs) from altitudes where they are thought to be produced. The Airborne Detector for Energetic Lightning Emissions (ADELE), an array of gamma-ray detectors, was flown near the tops of Florida thunderstorms in August/September 2009. The plane passed within 10 km horizontal distance of 1213 lightning discharges and only once detected a TGF. If these discharges had produced TGFs of the same intensity as those seen from space, every one should have been seen by ADELE. Separate and significant nondetections are established for intracloud lightning, negative cloud-to-ground lightning, and narrow bipolar events. We conclude that TGFs are not a primary triggering mechanism for lightning. We estimate the TGF-to-flash ratio to be on the order of 10^(â2) to 10^(â3) and show that TGF intensities cannot follow the well-known power-law distribution seen in earthquakes and solar flares, due to our limits on the presence of faint events
Variational formulas and cocycle solutions for directed polymer and percolation models
We discuss variational formulas for the law of large numbers limits of certain models of motion in a random medium: namely, the limiting time constant for last-passage percolation and the limiting free energy for directed polymers. The results are valid for models in arbitrary dimension, steps of the admissible paths can be general, the environment process is ergodic under spatial translations, and the potential accumulated along a path can depend on the environment and the next step of the path. The variational formulas come in two types: one minimizes over gradient-like cocycles, and another one maximizes over invariant measures on the space of environments and paths. Minimizing cocycles can be obtained from Busemann functions when these can be proved to exist. The results are illustrated through 1+1 dimensional exactly solvable examples, periodic examples, and polymers in weak disorder
Stationary cocycles and Busemann functions for the corner growth model
We study the directed last-passage percolation model on the planar square lattice with nearest-neighbor steps and general i.i.d. weights on the vertices, out- side of the class of exactly solvable models. Stationary cocycles are constructed for this percolation model from queueing fixed points. These cocycles serve as bound- ary conditions for stationary last-passage percolation, solve variational formulas that characterize limit shapes, and yield existence of Busemann functions in directions where the shape has some regularity. In a sequel to this paper the cocycles are used to prove results about semi-infinite geodesics and the competition interface
Association of homocysteine and methylene tetrahydrofolate reductase (MTHFR C677T) gene polymorphism with coronary artery disease (CAD) in the population of North India
The implications of the methylene tetrahydrofolate reductase (MTHFR) gene and the level of homocysteine in the pathogenesis of coronary artery disease (CAD) have been extensively studied in various ethnic groups. Our aim was to discover the association of MTHFR (C677T) polymorphism and homocysteine level with CAD in north Indian subjects. The study group consisted of 329 angiographically proven CAD patients, and 331 age and sex matched healthy individuals as controls. MTHFR (C677T) gene polymorphism was detected based on the polymerase chain reaction and restriction digestion with HinfI. Total homocysteine plasma concentration was measured using immunoassay. T allele frequency was found to be significantly higher in patients than in the control group. We found significantly elevated levels of mean homocysteine in the patient group when compared to the control group (p = 0.00). Traditional risk factors such as diabetes, hypertension, smoking habits, a positive family history and lipid profiles (triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol), were found significantly associated through univariate analysis. Furthermore, multivariable logistics regression analysis revealed that CAD is significantly and variably associated with diabetes, hypertension, smoking, triglycerides and HDL-cholesterol. Our findings showed that MTHFR C677T polymorphism and homocysteine levels were associated with coronary artery disease in the selected population
Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations
Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease
Studies of magnetotail dynamics and energy evolution during substorms using MHD simulations
We examine the distribution and propagation of energy in the plasma sheet
and lobes using observations and simulations for three substorms. The
substorms occurred on 9 March 1995, 10 December 1996, and 27 August 2001
and have been simulated using the Lyon-Fedder-Mobarry magneto-hydrodynamic
code. All three events occur over North America and show a clear substorm
current wedge over the ground magnetometer chains of Alaska, Canada, and
Greenland. The three simulations show the thinning of the plasma sheet
during the growth phase of the event and an increase in the relative amount
of thermal energy due to the compression of the plasma sheet. Generally, the
total lobe energy, polar cap flux, and lobe magnetic field strength
simultaneously increase during the growth phase, and polar cap flux and
total lobe energy only start dropping at substorm onset, as measured by the
CANOPUS magnetometer chain. Starting at time of onset and continuing
throughout the expansion phase a transfer of magnetic energy from the lobes
into the plasma sheet occurs, with the increase in the plasma sheet energy
ranging from 30â40% of the energy that is released from the lobes
Histophysiological study of aluminum chloride effect on male rats
This study was designed to detect the effects of aluminum chloride AlCl3 on some pathophysiological features of adult male rats. Eighteen rats were divided to 3 groups of 6 animals each. These included untreated control and 2 treated groups received AlCl3 at the doses 40 and 80 mg/kg of body weight, orally and daily for 30 days. The following parameters were recorded: Body weight (weekly), central nervous system activity tests (weekly), hematological examinations at 15 and 30 days of experimentally and gross and histopathology for brain, liver, kidneys and heart at the day (30). The results showed a significant decrease in body weight mean of 3rd group (80 mg/kg) at 4th week, a significant decrease in the activity associated with time progress in experiment by recording (moving onset, square crossed and rearing in 3 minutes, negative geotaxis) tests, there were no significant differences between groups at pack cell volume and hemoglobin concentration with a significant decrease in total leukocyte count at 2nd group (40 mg/kg). Differential leukocyte count revealed significant increase in lymphocyte at day 30. Histopathological changes were neuronal vaculation and proliferation of microgelial cells in brain, vacular degeneration and lymphocytic infiltrations in hepatic parenchyma with mild portal fibrosis in liver, at kidneys there were cloudy swelling, coagulative necrosis to the renal tubular epithelium, more severely noticed at 3rd group, no pathological changes were noticed at myocardium and coronary arteries at both treated groups
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