1,096 research outputs found
Culture and state boredom: A comparison between European Canadians and Chinese
The primary goal of the present research was to examine cross-cultural validity of the Multidimensional State Boredom Scale (MSBS) by comparing a European Canadian sample and a Chinese sample. The secondary goal was to explore cross-cultural differences in the actual experience of boredom between European Canadian and Chinese participants when they completed a psychological survey. After establishing cross-cultural validity of the MSBS by eliminating items that functioned differentially across the two cultural groups, we found that European Canadians scored higher on the MSBS than did Chinese. Results are consistent with the literature on cultural differences in ideal affect, such that European North Americans (vs. East Asians) tend to value high-arousal positive affects (e.g., excitement) more, and low-arousal positive affect less (Tsai, Knutson, & Fung, 2006)
Reduced T-cadherin expression and promoter methylation are associated with the development and progression of hepatocellular carcinoma
Theoretical evidence for the superluminality of evanescent modes
Though both theoretical and experimental investigations have revealed the
superluminal behavior of evanescent electromagnetic waves, there are many
disputes about the physical meaning and validity of such superluminal
phenomenon, which is due to the fact that the traditional investigations are
based on the theory of tunneling time, and concerned with the problem of what
the group velocity of evanescent waves means. In this paper, by studying the
quantum probability amplitude for photons to propagate over a spacelike
interval along an undersized waveguide, we present theoretical evidence for
such superluminality
Diverse Profiles of AI-1 Type Quorum Sensing Molecules in Cultivable Bacteria from the Mangrove (Kandelia obovata) Rhizosphere Environment
Highly Enhanced Concentration and Stability of Reactive Ce^3+ on Doped CeO_2 Surface Revealed In Operando
Trivalent cerium ions in CeO_2 are the key active species in a wide range of catalytic and electro-catalytic reactions. We employed ambient pressure X-ray photoelectron spectroscopy and electrochemical impedance spectroscopy to quantify simultaneously the concentration of the reactive Ce^3+ species on the surface and in the bulk of Sm-doped CeO_2(100) in hundreds of millitorr of H2–H2O gas mixtures. Under relatively oxidizing conditions, when the bulk cerium is almost entirely in the 4+ oxidation state, the surface concentration of the reduced Ce^3+ species can be over 180 times the bulk concentration. Furthermore, in stark contrast to the bulk, the surface’s 3+ oxidation state is also highly stable, with concentration almost independent of temperature and oxygen partial pressure. Our thermodynamic measurements reveal that the difference between the bulk and surface partial molar entropies plays a key role in this stabilization. The high concentration and stability of reactive surface Ce^3+ over wide ranges of temperature and oxygen partial pressure may be responsible for the high activity of doped ceria in many pollution-control and energy-conversion reactions, under conditions at which Ce^3+ is not abundant in the bulk
Superluminal Behaviors of Modified Bessel Waves
Much experimental evidence of superluminal phenomena has been available by
electromagnetic wave propagation experiments, with the results showing that the
phase time do describe the barrier traversal time. Based on the extrapolated
phase time approach and numerical methods, we show that, in contrary to the
ordinary Bessel waves of real argument, the group velocities of modified Bessel
waves are superluminal, and obtain the following results: 1) the group
velocities increase with the increase of propagation distance, which is similar
to the evanescent plane-wave cases; 2) for large wave numbers, the group
velocities fall off as the wave numbers increase, which is similar to the
evanescent plane-wave cases; 3) for small wave numbers, the group velocities
increase with the increase of wave numbers, this is different from the
evanescent plane-wave cases.Comment: 4 pages, 2 figure
Experimental Free-Space Distribution of Entangled Photon Pairs over a Noisy Ground Atmosphere of 13km
We report free-space distribution of entangled photon pairs over a noisy
ground atmosphere of 13km. It is shown that the desired entanglement can still
survive after the two entangled photons have passed through the noisy ground
atmosphere. This is confirmed by observing a space-like separated violation of
Bell inequality of . On this basis, we exploit the distributed
entangled photon source to demonstrate the BB84 quantum cryptography scheme.
The distribution distance of entangled photon pairs achieved in the experiment
is for the first time well beyond the effective thickness of the aerosphere,
hence presenting a significant step towards satellite-based global quantum
communication.Comment: 4 pages, 3 figure
DSTYK Promotes Metastasis and Chemoresistance via EMT in Colorectal Cancer
Objective: Tumor metastasis and resistance to chemotherapy are two critical factors that contribute to the high death rate of colorectal cancer (CRC) patients. Metastasis is facilitated by the epithelial-mesenchymal transition (EMT) of tumor cells, which has emerged not only as a fundamental process during metastasis, but is also a key process leading to chemoresistance of cancer cells. However, the underlying mechanisms of EMT in CRC cell remain unknown. Here, we aim to assess the role of dual serine/threonine and tyrosine protein kinase (DSTYK) in CRC metastasis and chemoresistance. Methods: To study the role of DSTYK in TGF-β-induced EMT, we employed techniques including Crispr/Cas9 knockout (KO) to generate DSTYK KO cell lines, RT-PCR to detect the mRNA expression, immunofluorescence analyses, and western blots to detect protein levels of DSTYK in the following 4 cell lines: control LS411N-TβRII and LS411N-TβRII/DSTYK KO, control LS513 and LS513/DSTYK KO cells, treated with/without TGF-β. The effects of DSTYK on apoptosis were investigated by MTT assays, flow cytometry assays, and TUNEL assays. The expression of DSTYK in CRC patients and its correlation with EMT markers were determined by bioinformatics analysis. For in vivo analysis, both xenograft and orthotopic tumor mouse models were employed to investigate the function of DSTYK in chemoresistance and metastasis of tumors. Results: In this study, we demonstrate that the novel kinase DSTYK promotes both TGF-β-induced EMT and the subsequent chemoresistance in CRC cells. DSTYK KO significantly attenuates TGF-β–induced EMT and chemoresistance in CRC cells. According to the Gene Expression Omnibus (GEO) database, the expression of DSTYK is not only positively correlated to the expression of TGF-β, but proportional to the death rate of CRC patients as well. Evidently, the expression of DSTYK in the metastatic colorectal cancer samples from patients was significantly higher than that of primary colorectal cancer samples. Further, we demonstrate in mouse models that chemotherapeutic drug treatment suppresses the growth of DSTYK KO tumors more effectively than control tumors. Conclusion: Our findings identify DSTYK as a novel protein kinase in regulating TGF-β–mediated EMT and chemoresistance in CRC cells, which defines DSTYK as a potential therapeutic target for CRC therapy
Moving average reversion strategy for on-line portfolio selection
Ministry of Education, Singapore under its Academic Research Funding Tier 1The short version of this work appeared at the 29th International Conference on Machine Learning (ICML 2012).</p
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