Detection prospects of light pseudoscalar Higgs boson at the LHC

The discovery potential of light pseudo scalar Higgs boson for the mass range 10-60 GeV is explored. In the context of the next-to-minimal supersymmetric standard(NMSSM) model, the branching fraction of light pseudo scalar Higgs boson decaying to a pair of photon can be quite large. A pair of light pseudo scalar Higgs boson produced indirectly through the standard model Higgs boson decay yields multiple photons in the final state and the corresponding production rate is restricted by ATLAS data. Discussing the impact of this constraint in the NMSSM, the detection prospects of light pseudoscalar Higgs boson in the channel consisting of at least three photons, a lepton and missing transverse energy are reported. It is observed that the possibilities of finding the pseudoscalar Higgs boson for the above mass range are promising for an integrated luminosity $\mathcal{L}=100 \text{fb}^{-1}$ with moderate significances, which can reach to more than 5$\sigma$ for higher luminosity options.Comment: 24 pages, 4 figures, updated reference

Study Of Phenothiazine On p53 Core Domain Mutant Y220C: Finding The Anti-tumor Activity Of Phenothiazine

The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small molecules. We have attempted with the help of virtual screening and molecular docking approach using Lamarckian Genetic Algorithm to elucidate the extent of specificity of p53 cancer mutation Y220C towards different class of Phenothiazines (an anti-cancer agent). 

The 393 residue p53 tumor suppressor protein exists in a dynamic equilibrium to form homotetramers. Each chain comprises several functional domains. The N terminal part of the protein consists of the trans-activation domain (residues 1–63) followed by a proline rich region (64– 92). The central (core) domain (p53 core domain) is responsible for binding. The C terminal part of p53 contains the tetramerization domain (residues 326–355) and the negative regulatory domain at the extreme C terminus (363–393), which contains phosphorylation and acetylation sites and regulates the DNA binding activity of p53.

The docking result of the study of 2,000 Phenothiazines demonstrated that the binding energies were in the range of -10.54 kcal/mol to -1.14 kcal/mol, with 8 molecules showing hydrogen bonds with the active site residues (Lys 164). All the selected 2000 inhibitors were selected on the basis of the structural specificity to the enzyme towards its substrate and inhibitors. Our research provides a blueprint for the design of more potent and specific drugs that rescue p53-Y220C

Correlation between peak expiratory flow rate and pectoralis muscle length

Background: Peak expiratory flow rate (PEFR) is a measure of the maximum speed of exhalation after a deep inspiration. The peak expiratory flow is measured by a device named peak flow meter. This study concentrates on the correlation of the PEFR with the pectoral muscle length.Methods: It is a cross sectional study of 30 convenient samples based on gender distribution where the PEFR and pectoralis muscle length were measured in the subjects.Results: Statistical analysis shows that there is a significant correlation between right pectoralis major general muscle length and PEFR (p=0.030), left pectoralis major general muscle length and PEFR (p=0.014), right pectoralis major clavicular end muscle length with PEFR (p=0.010).Conclusions: There is a significant correlation between peak expiratory flow and pectoralis muscle length.

Prevalence of panic and agoraphobia in post COVID-19 patients

Background: COVID-19 pandemic and quarantine of people who were tested positive made more cautious and anxious when being out in public. This study concentrates on the prevalence of panic and agoraphobia using panic and agoraphobia scale. Methods: Survey research study of 121 subjects using web-based data collection (Google form). Results: The result were obtained using panic and agoraphobia scale. Statistical analysis did not show considerable panic attack and agoraphobia in people who were tested positive for COVID-19. Conclusions: The study population did not show considerable panic attack and agoraphobia after being quarantined or hospitalised during 1st, 2nd and 3rd wave of COVID-19.

A New Approach to solve Fuzzy Transportation Problem for Trapezoidal Number

In this paper we are study on fuzzy transportation problem for industries to reduce the transportation cost of commodity from one source to another source. In this paper we are taking transportation cost, demand and supply all are in fuzzy trapezoidal number because the fuzzy number satisfy the condition of vagueness. Here we are using the propose algorithm to obtained the fuzzy optimal solution of fuzzy transportation problem with membership function. The solution procedure is illustrated with numerical example

Using policy gradient reinforcement learning on autonomous robot controllers

Robot programmers can often quickly program a robot to approximately execute a task under specific environment conditions. However, achieving robust performance under more general conditions is significantly more difficult. We propose a framework that starts with an existing control system and uses reinforcement feedback from the environment to autonomously improve the controller’s performance. We use the Policy Gradient Reinforcement Learning (PGRL) framework, which estimates a gradient (in controller space) of improved reward, allowing the controller parameters to be incrementally updated to autonomously achieve locally optimal performance. Our approach is experimentally verified on a Cye robot executing a room entry and observation task, showing significant reduction in task execution time and robustness with respect to un-modelled changes in the environment

Synthesis, characterization, and functionalization of zirconium tungstate (ZrW2O8) nano‐rods for advanced polymer nanocomposites

Nanomaterials based on zirconium tungstate (ZrW2O8) exhibit numerous outstanding properties that make them ideal candidates for the development of high-performance composites. Low coefficient of thermal expansion for advanced materials is a promising direction in the field of insulating nanocomposites. However, the agglomeration of zirconium tungstate (ZrW2O8)-based nanomaterials in the polymer matrix is a limiting factor in their successful applications, and studies on surface functionalization ZrW2O8 for advanced nanocomposites are very limited. In this work, ZrW2O8 nano-rods were synthesized using a hydrothermal method and subsequently functionalized in a solvent-free aqueous medium using dopamine. Both pristine and functionalized nano-rods were thoroughly characterized using Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis, X-ray diffraction, Scanning Electron Microscopy (SEM), and transmission electron microscopy techniques, which confirmed the successful functionalization of the nanomaterials. Polymer nanocomposites were also prepared using epoxy resin as a model matrix. Polymer nanocomposites with functionalized ZrW2O8 nano-rods exhibited low coefficient of thermal expansion and enhanced tensile properties. The improved properties of the nanocomposites render them suitable for electronic applications

Classical Langevin dynamics of a charged particle moving on a sphere and diamagnetism: A surprise

It is generally known that the orbital diamagnetism of a classical system of charged particles in thermal equilibrium is identically zero -- the Bohr-van Leeuwen theorem. Physically, this null result derives from the exact cancellation of the orbital diamagnetic moment associated with the complete cyclotron orbits of the charged particles by the paramagnetic moment subtended by the incomplete orbits skipping the boundary in the opposite sense. Motivated by this crucial, but subtle role of the boundary, we have simulated here the case of a finite but \emph{unbounded} system, namely that of a charged particle moving on the surface of a sphere in the presence of an externally applied uniform magnetic field. Following a real space-time approach based on the classical Langevin equation, we have computed the orbital magnetic moment which now indeed turns out to be non-zero, and has the diamagnetic sign. To the best of our knowledge, this is the first report of the possibility of finite classical diamagnetism in principle, and it is due to the avoided cancellation.Comment: Accepted for publication in EP