Law and Policy Responses to Disaster-Induced Financial Distress

This chapter treats disaster response policies directed at the economic recovery of private households. First, we examine problems of disaster-induced financial distress from a legal and economic perspective. We do this both qualitatively and quantitatively, and focussing on residential loans, using the victims of the 11 March 2011 tsunami as our example. Then, using doctrinal and systematic analysis, we set out the broad array of law and policy solutions tackling disaster-induced debt launched by the Japanese Government. On this basis, we assess the strengths and weaknesses of these measures in terms of their practical adequacy to prevent and mitigate financial hardship and examine them against multiple dimensions of disaster justice. We conclude with suggestions for improving financial disaster recovery by taking a prospective approach, preventing the snowballing of disaster-related losses, which we argue represents a equitable and effective way forward in allocating resources following future mega disasters

Multiple Dynamics in Tumor Microenvironment Under Radiotherapy.

The tumor microenvironment (TME) is an evolutionally low-level and embryonically featured tissue comprising heterogenic populations of malignant and stromal cells as well as noncellular components. Under radiotherapy (RT), the major modality for the treatment of malignant diseases [1], TME shows an adaptive response in multiple aspects that affect the efficacy of RT. With the potential clinical benefits, interests in RT combined with immunotherapy (IT) are intensified with a large scale of clinical trials underway for an array of cancer types. A better understanding of the multiple molecular aspects, especially the cross talks of RT-mediated energy reprogramming and immunoregulation in the irradiated TME (ITME), will be necessary for further enhancing the benefit of RT-IT modality. Coming studies should further reveal more mechanistic insights of radiation-induced instant or permanent consequence in tumor and stromal cells. Results from these studies will help to identify critical molecular pathways including cancer stem cell repopulation, metabolic rewiring, and specific communication between radioresistant cancer cells and the infiltrated immune active lymphocytes. In this chapter, we will focus on the following aspects: radiation-repopulated cancer stem cells (CSCs), hypoxia and re-oxygenation, reprogramming metabolism, and radiation-induced immune regulation, in which we summarize the current literature to illustrate an integrated image of the ITME. We hope that the contents in this chapter will be informative for physicians and translational researchers in cancer radiotherapy or immunotherapy