10 research outputs found
The hormonal control of ejaculation
Hormones regulate all aspects of male reproduction, from sperm production to sexual drive.
Although emerging evidence from animal models and small clinical studies in humans clearly point to a role
for several hormones in controlling the ejaculatory process, the exact endocrine mechanisms are unclear.
Evidence shows that oxytocin is actively involved in regulating orgasm and ejaculation via peripheral, central
and spinal mechanisms. Associations between delayed and premature ejaculation with hypothyroidism
and hyperthyroidism, respectively, have also been extensively documented. Some models suggest that
glucocorticoids are involved in the regulation of the ejaculatory reflex, but corresponding data from human
studies are scant. Oestrogens regulate epididymal motility, whereas testosterone can affect the central
and peripheral aspects of the ejaculatory process. Overall, the data of the endocrine system in regulating
the ejaculatory reflex suggest that widely available endocrine therapies might be effective in treating sexual
disorders in these men. Indeed, substantial evidence has documented that treatments of thyroid diseases are
able to improve some ejaculatory difficulties