1,490 research outputs found
Onsager-Machlup action-based path sampling and its combination with replica exchange for diffusive and multiple pathways
For sampling multiple pathways in a rugged energy landscape, we propose a
novel action-based path sampling method using the Onsager-Machlup action
functional. Inspired by the Fourier-path integral simulation of a quantum
mechanical system, a path in Cartesian space is transformed into that in
Fourier space, and an overdamped Langevin equation is derived for the Fourier
components to achieve a canonical ensemble of the path at a finite temperature.
To avoid "path trapping" around an initially guessed path, the path sampling
method is further combined with a powerful sampling technique, the replica
exchange method. The principle and algorithm of our method is numerically
demonstrated for a model two-dimensional system with a bifurcated potential
landscape. The results are compared with those of conventional transition path
sampling and the equilibrium theory, and the error due to path discretization
is also discussed.Comment: 20 pages, 5 figures, submitted to J. Chem. Phy
Thermally excited Trivelpiece–Gould modes as a pure electron plasma temperature diagnostic
Thermally excited plasma modes are observed in trapped, near-thermal-equilibrium pure electron plasmas over a temperature range of 0.05<kT<5 eV. The modes are excited and damped by thermal fluctuations in both the plasma and the receiver electronics. The thermal emission spectra together with a plasma-antenna coupling coefficient calibration uniquely determine the plasma (and load) temperature. This calibration is obtained from the mode spectra themselves when the receiver-generated noise absorption is measurable; or from separate wave reflection/absorption measurements; or from kinetic theory. This nondestructive temperature diagnostic agrees well with standard diagnostics, and may be useful for expensive species such as antimatter
Thermally excited fluctuations as a pure electron plasma temperature diagnostic
Thermally excited charge fluctuations in pure electron plasma columns provide a diagnostic for the plasma temperature over a range of 0.05 0.2, so that Landau damping is dominant and well modeled by theory. The third method compares the total (frequency-integrated) number delta N of fluctuating image charges on the wall antenna to a simple thermodynamic calculation. This method works when lambda(D)/R-p > 0.2
Recommended from our members
Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.
The goal of stem cell therapy for spinal cord injury (SCI) is to restore motor function without exacerbating pain. Induced pluripotent stem cells (iPSC) may be administered by autologous transplantation, avoiding immunologic challenges. Identifying strategies to optimize iPSC-derived neural progenitor cells (hiNPC) for cell transplantation is an important objective. Herein, we report a method that takes advantage of the growth factor-like and anti-inflammatory activities of the fibrinolysis protease, tissue plasminogen activator tPA, without effects on hemostasis. We demonstrate that conditioning hiNPC with enzymatically-inactive tissue-type plasminogen activator (EI-tPA), prior to grafting into a T3 lesion site in a clinically relevant severe SCI model, significantly improves motor outcomes. EI-tPA-primed hiNPC grafted into lesion sites survived, differentiated, acquired markers of motor neuron maturation, and extended βIII-tubulin-positive axons several spinal segments below the lesion. Importantly, only SCI rats that received EI-tPA primed hiNPC demonstrated significantly improved motor function, without exacerbating pain. When hiNPC were treated with EI-tPA in culture, NMDA-R-dependent cell signaling was initiated, expression of genes associated with stemness (Nestin, Sox2) was regulated, and thrombin-induced cell death was prevented. EI-tPA emerges as a novel agent capable of improving the efficacy of stem cell therapy in SCI
Locking Local Oscillator Phase to the Atomic Phase via Weak Measurement
We propose a new method to reduce the frequency noise of a Local Oscillator
(LO) to the level of white phase noise by maintaining (not destroying by
projective measurement) the coherence of the ensemble pseudo-spin of atoms over
many measurement cycles. This scheme uses weak measurement to monitor the phase
in Ramsey method and repeat the cycle without initialization of phase and we
call, "atomic phase lock (APL)" in this paper. APL will achieve white phase
noise as long as the noise accumulated during dead time and the decoherence are
smaller than the measurement noise. A numerical simulation confirms that with
APL, Allan deviation is averaged down at a maximum rate that is proportional to
the inverse of total measurement time, tau^-1. In contrast, the current atomic
clocks that use projection measurement suppress the noise only down to the
level of white frequency, in which case Allan deviation scales as tau^-1/2.
Faraday rotation is one of the possible ways to realize weak measurement for
APL. We evaluate the strength of Faraday rotation with 171Yb+ ions trapped in a
linear rf-trap and discuss the performance of APL. The main source of the
decoherence is a spontaneous emission induced by the probe beam for Faraday
rotation measurement. One can repeat the Faraday rotation measurement until the
decoherence become comparable to the SNR of measurement. We estimate this
number of cycles to be ~100 cycles for a realistic experimental parameter.Comment: 18 pages, 7 figures, submitted to New Journal of Physic
Thermal excitation of Trivelpiece-Gould modes in a pure electron plasma
Thermally excited plasma modes are observed in trapped, near-thermal-equilibrium pure electron plasmas over a temperature range of 0.05<T<5 eV. The measured thermal emission spectra together with a separate measurement of the wave absorption coefficient uniquely determines the temperature. Alternately, kinetic theory including the antenna geometry and the measured mode damping (i.e. spectral width) gives the plasma impedance, obviating the reflection measurement. This non-destructive temperature diagnostic agrees well with standard diagnostics, and may be useful for expensive species such as anti-matter
- …