Collective modes in a system with two spin-density waves: the `Ribault' phase of quasi-one-dimensional organic conductors

We study the long-wavelength collective modes in the magnetic-field-induced spin-density-wave (FISDW) phases experimentally observed in organic conductors of the Bechgaard salts family, focusing on phases that exhibit a sign reversal of the quantum Hall effect (Ribault anomaly). We have recently proposed that two SDW's coexist in the Ribault phase, as a result of Umklapp processes. When the latter are strong enough, the two SDW's become circularly polarized (helicoidal SDW's). In this paper, we study the collective modes which result from the presence of two SDW's. We find two Goldstone modes, an out-of-phase sliding mode and an in-phase spin-wave mode, and two gapped modes. The sliding Goldstone mode carries only a fraction of the total optical spectral weight, which is determined by the ratio of the amplitude of the two SDW's. In the helicoidal phase, all the spectral weight is pushed up above the SDW gap. We also point out similarities with phase modes in two-band or bilayer superconductors. We expect our conclusions to hold for generic two-SDW systems.Comment: Revised version, 25 pages, RevTex, 7 figure

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.

Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial with ibrutinib, the first-in-class BTK inhibitor, for patients with relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred in 10 of 13 (77%) patients with PCNSL, including five complete responses. The only PCNSL with complete ibrutinib resistance harbored a mutation within the coiled-coil domain of CARD11, a known ibrutinib resistance mechanism. Incomplete tumor responses were associated with mutations in the B-cell antigen receptor-associated protein CD79B

Medium-size-vessel vasculitis

Medium-size-artery vasculitides do occur in childhood and manifest, in the main, as polyarteritis nodosa (PAN), cutaneous PAN and Kawasaki disease. Of these, PAN is the most serious, with high morbidity and not inconsequential mortality rates. New classification criteria for PAN have been validated that will have value in epidemiological studies and clinical trials. Renal involvement is common and recent therapeutic advances may result in improved treatment options. Cutaneous PAN is a milder disease characterised by periodic exacerbations and often associated with streptococcal infection. There is controversy as to whether this is a separate entity or part of the systemic PAN spectrum. Kawasaki disease is an acute self-limiting systemic vasculitis, the second commonest vasculitis in childhood and the commonest cause of childhood-acquired heart disease. Renal manifestations occur and include tubulointerstitial nephritis and renal failure. An infectious trigger and a genetic predisposition seem likely. Intravenous immunoglobulin (IV-Ig) and aspirin are effective therapeutically, but in resistant cases, either steroid or infliximab have a role. Greater understanding of the pathogenetic mechanisms involved in these three types of vasculitis and better long-term follow-up data will lead to improved therapy and prediction of prognosis