On-Chip Cavity Optomechanical Coupling

On-chip cavity optomechanics, in which strong co-localization of light and mechanical motion is engineered, relies on efficient coupling of light both into and out of the on-chip optical resonator. Here we detail our particular style of tapered and dimpled optical fibers, pioneered by the Painter group at Caltech, which are a versatile and reliable solution to efficient on-chip coupling. First, a brief overview of tapered, single mode fibers is presented, in which the single mode cutoff diameter is highlighted. The apparatus used to create a dimpled tapered fiber is then described, followed by a comprehensive account of the procedure by which a dimpled tapered fiber is produced and mounted in our system. The custom-built optical access vacuum chambers in which our on-chip optomechanical measurements are performed are then discussed. Finally, the process by which our optomechanical devices are fabricated and the method by which we explore their optical and mechanical properties is explained. It is our expectation that this manuscript will enable the novice to develop advanced optomechanical experiments.Comment: 31 pages, 9 figure

Wavelength transduction from a 3D microwave cavity to telecom using piezoelectric optomechanical crystals

Microwave to optical transduction has received a great deal of interest from the cavity optomechanics community as a landmark application for electro-optomechanical systems. In this Letter, we demonstrate a novel transducer that combines high-frequency mechanical motion and a microwave cavity for the first time. The system consists of a 3D microwave cavity and a gallium arsenide optomechanical crystal, which has been placed in the microwave electric field maximum. This allows the microwave cavity to actuate the gigahertz-frequency mechanical breathing mode in the optomechanical crystal through the piezoelectric effect, which is then read out using a telecom optical mode. The gallium arsenide optomechanical crystal is a good candidate for low-noise microwave-to-telecom transduction, as it has been previously cooled to the mechanical ground state in a dilution refrigerator. Moreover, the 3D microwave cavity architecture can naturally be extended to couple to superconducting qubits and to create hybrid quantum systems

Shelf-edge frontal structure in the central East China Sea and its impact on low-frequency acoustic propagation

Author Posting. © IEEE, 2004. This article is posted here by permission of IEEE for personal use, not for redistribution. The definitive version was published in IEEE Journal of Oceanic Engineering 29 (2004): 1011-1031, doi:10.1109/JOE.2004.840842.Two field programs, both parts of the Asian Seas International Acoustics Experiment (ASIAEX), were carried out in the central East China Sea (28 to 30 N, 126 30 to 128 E) during April 2000 and June 2001. The goal of these programs was to study the interactions between the shelf edge environment and acoustic propagation at a wide range of frequencies and spatial scales. The low-frequency across-slope propagation was studied using a synthesis of data collected during both years including conductivity- temperature-depth (CTD) and mooring data from 2000, and XBT, thermistor chain, and wide-band source data from 2001. The water column variability during both years was dominated by the Kuroshio Current flowing from southwest to northeast over the continental slope. The barotropic tide was a mixed diurnal/semidiurnal tide with moderate amplitude compared to other parts of the Yellow and East China Sea. A large amplitude semidiurnal internal tide was also a prominent feature of the data during both years. Bursts of high-frequency internal waves were often observed, but these took the form of internal solitons only once, when a rapid off-shelf excursion of the Kuroshio coincided with the ebbing tide. Two case studies in the acoustic transmission loss (TL) over the continental shelf and slope were performed. First, anchor station data obtained during 2000 were used to study how a Kuroshio warm filament on the shelf induced variance in the transmission loss (TL) along the seafloor in the NW quadrant of the study region. The corresponding modeled single-frequency TL structure explained the significant fine-scale variability in time primarily by the changes in the multipath/multimode interference pattern. The interference was quite sensitive to small changes in the phase differences between individual paths/modes induced by the evolution of the warm filament. Second, the across-slope sound speed sections from 2001 were used to explain the observed phenomenon of abrupt signal attenuation as the transmission range lengthened seaward across the continental shelf and slope. This abrupt signal degradation was caused by the Kuroshio frontal gradients that produced an increasingly downward-refracting sound-speed field seaward from the shelf break. This abrupt signal dropout was explained using normal mode theory and was predictable and source depth dependent. For a source located above the turning depth of the highest-order shelf-trapped mode, none of the propagating modes on the shelf were excited, causing total signal extinction on the shelf

Growth inhibition in clonal subpopulations of a human epithelioid sarcoma cell line by retinoic acid and tumour necrosis factor alpha.

Epithelioid sarcoma is a highly malignant soft tissue tumour that is refractory to conventional chemotherapy and irradiation. Since permanent cell lines of this tumour are extremely rare, in vitro data on compounds with significant antiproliferative effects are still lacking. Therefore, we investigated the effects of retinoic acid (RA) and tumour necrosis factor alpha (TNF-alpha) on tumour cell proliferation of three different clonal subpopulations (GRU-1A, GRU-1B, GRU-1C) derived from the same human epithelioid sarcoma cell line, GRU-1. In GRU-1A both RA (P=0.01) and TNF-alpha (P=0.002) exhibited highly significant and dose-dependent growth inhibitory effects, which could further be increased by a combined application of both compounds (P<0.006). GRU-1B proved to be sensitive to RA (P=0.006), whereas no response to TNF-alpha was observed. GRU-1C was resistant to both RA and TNF-alpha. The antiproliferative effect of TNF-alpha was mediated by TNF receptor 1(TNF-R1) and correlated positively with both the number of TNF-R1 per cell and receptor affinity. No correlation was detected between RA-induced growth inhibition and the expression pattern of the RA receptors (RARs) RAR-alpha, RAR-beta, and RAR-gamma. Plating efficiency, however, could exclusively be reduced by RA in GRU-1B, the only cell line expressing RAR-alpha. Taken together, these data are the first showing significant antiproliferative effects in human epithelioid sarcoma by RA and TNF-alpha. Whereas the TNF-alpha response seems to depend on the expression of TNF-R1, no simple correlation could be found between RA sensitivity and the expression pattern of RARs