Different osteosyntheses for Colles' fracture: A mechanical study in 42 cadaver bones

Background and purpose In recent years several different plate designs for internal fixation of fractures of the distal radius have been developed. However, few biomechanical studies have been performed to compare these new implants. The purpose of this study was to compare the mechanical properties of 5 different commercially available plates (3 volar and 2 dorsal) with standard K-wire fixation using a distal radial cadaver model

Rosiglitazone and glimeperide: review of clinical results supporting a fixed dose combination

Type 2 diabetes has become a major burden to the health care systems worldwide. Among the drugs approved for this indication, glimepiride and rosiglitazone have gained substantial importance in routine use. While glimepiride stimulates β-cell secretion and leads to reduction of blood glucose values, rosiglitazone activates PPARγ and improves insulin resistance, at the vascular and metabolically active cells. Therefore, the combination of the two drugs may be an interesting approach to improve glycemic control and lower cardiovascular risk. A fixed combination of both drugs has been approved for clinical use in the US and EU. The combination of glimepiride and rosiglitazone is generally well tolerated and the use of a fixed combination may lead to improved adherence of the patients to their therapy. The purpose of this review is to evaluate the clinical data that have been published on this combination, appearing to represent a convenient way to obtain therapeutic targets in patients with type 2 diabetes mellitus

Modified polyacrylamide hydrogels and their application in removal of heavy metal ions

Modified crosslinked polyacrylamides having different functional groups were prepared by Mannich reaction using different an-tine compounds such as ethylenediamine (EDA), diethylenetriamine (DETA) and triethylenetetramine (TETA) and sulfomethylation reaction. Products were characterized by determination of their basic group content (BGC), hydroxymethyl group content (HMG), equilibrium degree of swelling (EDS) and FT-IR spectra. For Mannich reactions. BGC and EDS changed with a-mount of employed an-line compounds, reaction time and temperature. Sulfomethylation reactions gave products with high BGC and very high EDS. FT-IR spectroscopic analysis confirmed that a parallel hydrolysis reaction occurred along with the expected modification reactions. The products were used for removal of Cu(II), Cd(II) and Pb(II) ion under competitive and non-competitive conditions at different pH. The metal ion removal capacities changed depending their BGC and EDS. While the Mannich products were selective towards Cu(U) ion, the sulfomethylation products were highly selective to Pb(II) ions. The polymers were used several times by regeneration without loss of adsorption capacity and changing of selectivity properties. (C) 2003 Elsevier Science Ltd. All rights reserved