Comparative Antibacterial Activities of Some Monosaccharide and Disaccharide Benzoates

For comparative antibacterial studies a number of furanose (3, 5), pyranose (7, 9, 11, 13), and disaccharide benzoates (14, 15) were prepared by direct benzoylation method. Synthesized benzoates (3, 5, 7, 9, 11, 13-15) along with some starting materials were screened for in vitro antibacterial activity against ten human pathogenic bacteria viz. Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Escherichia coli, INABA ET (Vibrio), Pseudomonas species, Salmonella paratyphi, Salmonella typhi, and Shigella dysenteriae. The study revealed that the pyranose benzoate derivatives (7, 9, 11, 13) were more prone towards antibacterial functionality than that of the furanose benzoate (3, 5) and disaccharide benzoates (14, 15). DOI: http://dx.doi.org/10.17807/orbital.v7i2.69