EFFICACY OF AQUEOUS LEAF EXTRACT OF VERNONIA AMYGDALINA ON PLASMA LIPOPROTEIN AND OXIDATIVE STATUS IN DIABETIC RAT MODELS.

Many minor components of foods, such as secondary plant metabolites, have been shown to posses antioxidant activities, improving the effects of oxidative stress on diabetes and other disease conditions. This study evaluates the effect of aqueous extracts from Vernonia amygdalina   leaves on lipid profiles and oxidative stress in streptozotocin induced diabetic rats. The results showed that the streptozotocin induced diabetic rats were subjected to oxidative stress as was shown by the extent of lipid peroxidation (high malondialdehyde levels) present in the plasma. The aqueous extract of V. amygdalina leaves possessed antioxidant activity as shown by decreases in malondialdehyde levels. High values of LDL-cholesterol and triglycerides levels, which are typical of the diabetic condition, were also found in streptozotocin induced diabetic rats. The aqueous extract also significantly reduced triglyceride levels and normalized cholesterol concentrations. This shows that the aqueous extract of V. amygdalina leaves have both hypolipidaemic and antioxidant properties

Effects of Therapeutic Dose of Acetaminophen (Paractamol) on Liver Enzymes in Chronic Alcoholics

The effects of therapeutic doses of acetaminophen (paracetamol) on liver enzmes in chronic alcoholics were investigated using 4 groups of 20 subjects each. The results showed that the difference in mean serum bilirubin, AST, ALT and ALP values in indivduals taking therapeutic doses of paracetamol only were significantly increased in both chronic alcoholics not taking paracetamol and chronic alcoholics taking therapeutic doses of paracetamol (

Anti-arrythemic and anti-hyperlipidaemic potentials of aqueous garlic extract in hyper-cholesterolaemic rat

No Abstract. IJONAS Vol. 3 (2) 2007: pp. 214-22

Effects of Falciparum Malaria Infection on Some Hematological Indices and Renal functions

Parameters including some haematological and renal function indices were evaluated in 30 middle aged patients hospitalised for Plasmodium falciparum falciparum malaria at the Federal Medical Centre (FMC), Owerri. Also 30 apparently healthy age-matched controls were evaluated for the same parameters. Haematological parameters including haemoglobin (Hb) level, total WBC, differential leucocyte and platelet counts were performed using appropriate techniques. Blood urea was estimated using Diacetylmonoxime method and creatinine level was determined using alkaline picrate (Jaffe's reaction). The mean blood urea and creatinine values of P. falciparum malaria patients were significantly high (

Comparative study of oven and traditionally roasted suya: an indigenous Nigerian meat

No Abstract. Animal Production Research Avancees Vol. 3 (2) 2007: pp. 131-13

ANTI-LIPID PEROXIDATIVE ACTIVITY OF GONGRONEMA LATIFOLIUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.

This study was designed to investigate the anti-lipid peroxidative effects of aqueous extracts from Gongronema latifolium (Utazi) leaves in non-diabetic and streptozotocin-induced diabetic rats. We evaluated plasma lipid peroxidation product (malondialdehyde, MDA) and antioxidant enzyme, superoxide dismutase (SOD) in all the animals. Result demonstrated that the untreated diabetic rats were subjected to oxidative stress as indicated by significantly (P<0.05) low level of their antioxidant enzyme, superoxide dismutase (49. 86 ± 2.04 U/mg protein) and high plasma lipid peroxidation index (6.82 ± 2.04 nmol/ml) when compared with non-diabetic rats value of 82.5 ± 3.16 U/mg protein and 2.66 ± 0.72 nmol/ml respectively. The aqueous extract of G. latifolium leaves reversed this situation as shown by significantly (P<0.05) increase in the activity of superoxide dismutase (78.6 ± 3.26 U/mg protein) and decreased levels of plasma malondialdehyde (4.02 ± 0.64). In conclusion, the results suggest that aqueous extract of G. latifolium leaves possesses hypoglycemic as well as anti-lipid peroxidative properties