Emigration of the Dutch and their search of the "good life"

For the first time since the 1950s the Netherlands is experiencing an emigration wave. A large-scale survey on the determinants of emigration has shown that most Dutch emigrants are in search of the good life: space, nature, peace and quiet and friendly people. Two years after having stated their intention to emigrate, 24 percent had actually left the Netherlands.

STOCK PRICES AND EXCHANGE RATES IN AUSTRALIA: ARE COMMODITY PRICES THE MISSING LINK?

The relationship between stock prices and exchange rates is an important topic of long standing. But there are still significant gaps in our knowledge of this area, not least, the ambiguity about the sign of the effect of a change in one of these variables on the other. While there are many possible reasons for this ambiguity, one which we explore in the Australian context in this paper is the omission of commodity prices. We show that a bivariate relationship which omits commodity prices performs badly but that once commodity prices are added to the relationship, our results are plausible and robust. We also throw light on the commodity-currency issue and show that the link from the exchange rate to commodity prices is stronger and more consistent than that in the opposite direction.

Detection of transplanckian effects in the cosmic microwave background

Quantum gravity effects are expected to modify the primordial density fluctuations produced during inflation and leave their imprint on the cosmic microwave background observed today. We present a new analysis discussing whether these effects are detectable, considering both currently available data and simulated results from an optimal CMB experiment. We find that the WMAP (Wilkinson Microwave Anisotropy Probe) data show no evidence for the particular signature considered in this work but give an upper bound on the parameters of the model. However, a hypothetical experiment shows that with proper data, the trans-Planckian effects should be detectable through alternate sampling methods. This fuzzy conclusion is a result of the nature of the oscillations, since they give rise to a likelihood hypersurface riddled with local maxima. A simple Bayesian analysis shows no significant evidence for the simulated data to prefer a trans-Planckian model. Conventional Markov chain Monte Carlo (MCMC) methods are not suitable for exploring this complicated landscape, but alternative methods are required to solve the problem. This, however, requires extremely high-precision data.Comment: 9 pages, 22 figure

Anti-Müllerian Hormone Levels and Urinary Cortisol in Women With Chronic Abdominal Pain

AbstractObjectiveTo explore the association of hypothalamic–pituitary–adrenal activity with ovarian functioning in women with and without chronic abdominal pain (CAP).Design and SettingA secondary data analysis was performed with data from female participants in a natural history protocol at the National Institutes of Health.ParticipantsA total of 36 women (age range = 19–39 years, mean = 27.11 years) were included in the study.MethodsThis pilot study was conducted with a subset of participants enrolled in a natural history protocol conducted in the Hatfield Clinical Research Center at the National Institutes of Health. The parent study included participants with and without CAP who provided a 5-hour urine sample for determination of cortisol levels and serum samples for determination of circulating levels of cortisol, luteinizing hormone, and follicle-stimulating hormone. CAP was defined as presence or absence of chronic pain for at least 6 months and was determined via self-report.ResultsAnti-Müllerian hormone (AMH) concentrations declined significantly with age as expected. When AMH levels were dichotomized as normal or abnormal (defined as higher or lower than age-specific normative ranges, respectively), there were significant associations between abnormal AMH levels and CAP and urine cortisol levels. Participants with CAP or low urine cortisol levels were significantly more likely to have abnormal AMH levels.ConclusionResults suggest that chronic abdominal pain and hypothalamic–pituitary–adrenal dysregulation may be associated with abnormal AMH levels

Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort

We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children with invasive infection. aPSS consist of all components of PSS except lactate. aPSS predicted mortality in children with invasive infection (n = 4096; AUC 0.70 (95% CI 0.67-0.73)) and in children with sepsis (n = 1690; AUC 0.71 (0.67-0.76)). aPSS can be an adequate tool to predict outcome in children admitted to PICU with invasive infection or sepsis, especially in situations where lactate is not available within 60 min. Keywords: Child; Mortality; Organ dysfunction; Score; Sepsis; Septic shoc

B Cell Activation and Escape of Tolerance Checkpoints:Recent Insights from Studying Autoreactive B Cells

Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the production of autoantibodies, secretion of cytokines, and presentation of autoantigens to T cells. However, the mechanisms that underlie the development of autoreactive B cells are not well understood. Here, we review recent studies leveraging novel techniques to identify and characterize (auto)antigen-specific B cells. The insights gained from such studies pertaining to the mechanisms involved in the escape of tolerance checkpoints and the activation of autoreactive B cells are discussed. In addition, we briefly highlight potential therapeutic strategies to target and eliminate autoreactive B cells in autoimmune diseases

Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis:a retrospective analysis of a Dutch national cohort

We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children with invasive infection. aPSS consist of all components of PSS except lactate. aPSS predicted mortality in children with invasive infection (n = 4096; AUC 0.70 (95% CI 0.67-0.73)) and in children with sepsis (n = 1690; AUC 0.71 (0.67-0.76)). aPSS can be an adequate tool to predict outcome in children admitted to PICU with invasive infection or sepsis, especially in situations where lactate is not available within 60 min

Mouse Natural Killer (NK) Cells Express the Nerve Growth Factor Receptor TrkA, which Is Dynamically Regulated

Background: Nerve growth factor (NGF) is a neurotrophin crucial for the development and survival of neurons. It also acts on cells of the immune system which express the NGF receptors TrkA and p75 NTR and can be produced by them. However, mouse NK cells have not yet been studied in this context. Methodology/Principal Findings: We used cell culture, flow cytometry, confocal microscopy and ELISA assays to investigate the expression of NGF receptors by NK cells and their secretion of NGF. We show that resting NK cells express TrkA and that the expression is different on NK cell subpopulations defined by the relative presence of CD27 and CD11b. Expression of TrkA is dramatically increased in IL-2-activated NK cells. The p75 NTR is expressed only on a very low percentage of NK cells. Functionally, NGF moderately inhibits NK cell degranulation, but does not influence proliferation or cytokine production. NK cells do not produce NGF. Conclusions/Significance: We demonstrate for the first time that mouse NK cells express the NGF receptor TrkA and tha