Black Extended Objects, Naked Singularities and P-Branes

We treat the horizons of charged, dilaton black extended objects as quantum mechanical objects. We show that the S matrix for such an object can be written in terms of a p-brane-like action. The requirements of unitarity of the S matrix and positivity of the p-brane tension equivalent severely restrict the number of space-time dimensions and the allowed values of the dilaton parameter a. Generally, black objects transform at the extremal limit into p-branes.Comment: 9 pages, REVTE

Signatures of Fermi surface reconstruction in Raman spectra of underdoped cuprates

We have calculated the Raman B$_{1g}$ and B$_{2g}$ spectra as a function of temperature, as well as doping, for the underdoped cuprates, using a model based on the resonating valence-bond spin-liquid. We discuss changes in intensity and peak position brought about by the presence of a pseudogap and the implied Fermi surface reconstruction, which are elements of this model. Signatures of Fermi surface reconstruction are evident as a sharp rise in the doping dependence of the antinodal to nodal peak ratio which occurs below the quantum critical point. The temperature dependence of the B$_{1g}$ polarization can be used to determine if the superconducting gap is limited to the Fermi pocket, as seen in angle resolved photoemission spectroscopy, or extends beyond. We find that the slope of the linear low energy B$_{2g}$ spectrum maintains its usual d-wave form, but with an effective gap which reflects the gap amplitude projected on the Fermi pocket. Our calculations capture the main qualitative features revealed in the extensive data set available on the HgBa$_2$CuO$_{4+\delta}$ (Hg-1201) cuprate.Comment: 13 pages, 14 figure

The role of microglia and Toll-like Receptor-4 in neuronal apoptosis in a subarachnoid hemorrhage model

BACKGROUND A subarachnoid hemorrhage (SAH) is a bleed into the subarachnoid space surrounding the brain. This disease affects roughly 30,000 Americans each year and approximately one in six affected individuals die at the time of the ictal event. Individuals that do survive suffer from many complications including delayed cerebral vasospasm (DCV), cerebral edema, fever, and increased intracranial pressure (ICP) amongst others. These patients often suffer from brain damage due to neuronal apoptosis as a consequence of excess neuroinflammation. Microglia, the resident macrophage of the central nervous system, and Toll-like Receptor-4 (TLR4), a pro-inflammatory transmembrane receptor, have both been shown to play a role in the neuroinflammation seen in SAH. RBC components have been shown to activate microglial TLR4, and this event is suggested to trigger downstream mechanisms leading to neuronal apoptosis. The presented research takes a closer look at the role of microglial TLR4 in early neuronal apoptosis seen in an SAH model. METHODS All mice used were 10- to 12-week-old males on a C57BL/6 background: TLR4−/−, MyD88−/−, TRIF−/− and wild type (WT). To induce an SAH, a total of 60 ul of arterial blood from a donor WT mouse was injected for over 30 seconds into another mouse. For in vitro experiments, either primary microglia (PMG) or murine microglial BV2 cells were used. Microglia were separated from murine neuronal HT22 cells by 3um cell culture inserts or transwells, before being stimulated with lipopolysaccharide (LPS), red blood cells (RBCs), or RBC components including hemin (structurally similar to heme) and hemoglobin. In vivo samples were studied using either immunohistochemistry (IHC) or Fluorescence Activated Cell Sorting (FACS), and in vitro cells were studied using IHC and Light Microscopy. Neuronal cell death was measured using TUNEL and/or FloroJade C (FJC) assays. Cognitive function after SAH was measured using the Barnes Maze protocol. RESULTS In a 24-hour time course, more death occurred in the HT22 cells associated with BV2s treated with RBCs for 12-hour and 24-hour incubation time points as compared to 1-hour and 3-hour time points. Similar results were seen in the WT PMGs, as HT22 apoptosis increased in the RBC treated WT groups as the incubation time points increased. The WT PMG and MyD88−/− RBC treated PMGs showed significant death as compared to a WT untreated control (p<0.05) using a FJC assay, and both showed more death in a TUNEL assay as compared to an untreated control. WT mice treated with whole blood and hemoglobin had significantly more apoptosis as compared with a normal saline (NS)-treated control mouse (p<0.05). WT PMGs treated with whole blood and hemoglobin had more apoptosis as compared with an untreated control. MyD88-/- treated with RBC, hemoglobin, and hemin had more HT22 cell death compared with other genotypes treated with the same component. For the Barnes Maze, TLR4−/− mice performed significantly less total errors than WT mice on POD5 and 6 (p<0.01), and took significantly less time to reach the goal chamber on POD4, POD5 (p<0.05), and POD6 (p<0.01). CONCLUSION Our experimental results suggest that a microglial TLR4-dependent, MyD88-independent pathway is involved in neuronal apoptosis very early in an SAH model via RBC and hemoglobin activation, and that neuronal cell apoptosis due to TLR4 expression may be related to SAH-related cognitive and behavioral deficits. Our results suggest that TRIF may be the intracellular adaptor that is involved in this mechanism, but further experiments are needed to confirm this

Analysis of body calcium (regional changes in body calcium by in vivo neutron activation analysis)

The effect of space flight on urine and fecal calcium loss was documented during the three long-term Skylab flights. Neutron activation analysis was used to determine regional calcium loss. Various designs for regional analysis were investigated

Dilatonic Black Holes, Naked Singularities and Strings

We extend a previous calculation which treated Schwarschild black hole horizons as quantum mechanical objects to the case of a charged, dilaton black hole. We show that for a unique value of the dilaton parameter `a', which is determined by the condition of unitarity of the S matrix, black holes transform at the extremal limit into strings.Comment: 8 pages, REVTE

Vidéopoésie

Canadian digital artist and videopoet Valerie LeBlanc and Canadian poet, musician, and videopoet ******** Daniel H. Dugas have been working together since 1990. Daniel H. Dugas was born in Montréal, QC. Poet, videographer, essayist and musician, Dugas has exhibited and participated in exhibitions, festivals and literary events in Canada and internationally. His ninth book of poetry: L’esprit du temps/The Spirit of the Time won the 2016 Antonine-Maillet-Acadie Vie award and the 2018 Éloizes: Artiste de l’année en littérature. daniel.basicbruegel.com | Videos distributed through: vtape.org *********** Pluridisciplinary artist and writer, Valerie LeBlanc was born in Halifax, Nova Scotia. She has worked and presented throughout Canada and internationally. LeBlanc’s first video: Homecoming was collected and screened by the National Gallery of Canada. She is the creator of the MediaPackBoard (MPB), a portable screening / performance device. valerie.basicbruegel.com | Videos distributed through: vtape.org ********** Their specific uniqueness within the videopoetry world also lies in the musicality of speaking two languages. LeBlanc’s first language is English and her second French; and Dugas’ is French with English second. (Sarah Tremlett)This project is supported by the Marilyn I. Walker School of Fine and Performing Arts at Brock University and the New Brunswick Arts Board. / Ce projet est soutenu par le Marilyn I. Walker School of Fine and Performing Arts à Brock University et par le Conseil des arts du Nouveau-Brunswick

Dual-species quantum degeneracy of potassium-40 and rubidium-87 on an atom chip

In this article we review our recent experiments with a 40K-87Rb mixture. We demonstrate rapid sympathetic cooling of a 40K-87Rb mixture to dual quantum degeneracy on an atom chip. We also provide details on efficient BEC production, species-selective magnetic confinement, and progress toward integration of an optical lattice with an atom chip. The efficiency of our evaporation allows us to reach dual degeneracy after just 6 s of evaporation - more rapidly than in conventional magnetic traps. When optimizing evaporative cooling for efficient evaporation of 87Rb alone we achieve BEC after just 4 s of evaporation and an 8 s total cycle time.Comment: 8 pages, 4 figures. To be published in the Proceedings of the 20th International Conference on Atomic Physics, 2006 (Innsbruck, Austria

Fast high-efficiency integrated waveguide photodetectors using novel hybrid vertical/butt coupling geometry

We report a novel coupling geometry for integrated waveguide photodetectors−a hybrid vertical coupling/butt coupling scheme that allows the integration of fast, efficient, photodetectors with conventional double heterostructure waveguides. It can be employed to yield a planar, or pseudo-planar, surface that supports further levels of integration. The approach is demonstrated with a 25-µm-long p-i-n detector integrated with an InP/InGaAsP/InP waveguide, which displays a high (~90%) efficiency and large (~15 GHz) bandwidth. This is the fastest high-efficiency integrated waveguide photodetector reported to date